DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptpn21

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001139671.1	Gene:	Ptpn21 / 24000	MGIID:	1344406	Length:	1176	Species:	Mus musculus

Alignment Length:	1118	Identity:	242/1118 - (21%)
Similarity:	399/1118 - (35%)	Gaps:	349/1118 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 HDLRSEPH--AYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLP 630
            ||:.:..|  ::|.....|....:..:|             |..|..:|..|... :..::.||.
Mouse   257 HDIANMSHNKSFFALELANKEETIQFQT-------------EDMETAKYVWRLCV-ARHKFYRLN 307

  Fly   631 --SVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWP 693
              |:::..|.:..:.:|.         |..:..|.||..  .:||.|     ||..:.:.|..:.
Mouse   308 QCSLQTQAATLNSVRRGS---------SSRMSLPKPQPY--AMPPPP-----QLHYNGHYTEPFA 356

  Fly   694 KPEGRVESYILKWWPSDN-----------------PGRVQTKNVSENKSADDLSTVRVLIGELMP 741
            ..:..:      :.|:.|                 .||::..:|....|.:.|:|       |.|
Mouse   357 SSQDNI------FVPNKNGFYCHSQTSLDRTQIDLSGRIRNGSVYSAHSTNSLNT-------LQP 408

  Fly   742 GVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTP--------- 797
            .:|   ....:|...::|...:.|..:|..:...:            |..||.|||
Mouse   409 YLQ---PSPMSSNPSITGSDVMRPDYIPSHRHSAL------------IPPSYRPTPDYETVMKQL 458

  Fly   798 -----------QSSSKFDI---YRFSLGDA------EIRDKEKLANDTDRKVTFTGLVPGRLYNI 842
                       .|....:|   |.:|..||      |||:...|.:.......|.       .|.
Mouse   459 NRGMVHADRHSHSLRNLNIGSSYAYSRPDALVYSQPEIREHPHLTSPQSAHYPFN-------LNY 516

  Fly   843 TVWTVSG-----------GVASLP----IQRQDRLYPEPITQLHATNITDTEI---SLRWDLPKG 889
            :..:.|.           |..|:|    :|.|.:.||.|       ||..|::   ...:..|:.
Mouse   517 SFHSQSPYPYPAERRPVVGAVSVPELTNVQLQAQDYPAP-------NIMRTQVYRPPPPYPYPRP 574

  Fly   890 EYNDFDIA---YLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESS--VLRS----SS 945
            ..:..|::   |:::.|   .::.||        |.|.:      |::..|.|  |..|    |.
Mouse   575 ANSTPDLSRHLYISSSN---PDLITR--------RVHHS------VQTFQEDSLPVAHSLQEVSE 622

  Fly   946 PLSASFTTNEAVPGRVERFHPTDVQPSEINFEW------SLPSSEANGVIRQFSIA--------- 995
            ||:|      |....:::.:..::......||.      ::.:|.|:...|.||..
Mouse   623 PLTA------ARHAHLQKRNSIEIAGLTHGFEGLRLKERTVSASAADVAPRTFSAGSQSSVFSDK 681

  Fly   996 -------------YTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREY- 1046
                         |::..:|:||.|....|||...:.::....:......:.:....|..|..|
Mouse   682 MKQEGTEEQEGGRYSHKKSLSDATMLIHSSEEDEDLEEDSSREQAISAVSEPRLTAAFSQELNYP 746

  Fly  1047 -RQTMPILAP-----PRP-ATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKN 1104
             ....||..|     |:| .|:  |.:..:..|.:.                    :|.|.....
Mouse   747 CASATPITGPLHIFEPKPHVTE--PEKRAKDISPVH--------------------LVVETHRPR 789

  Fly  1105 ASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTEN---------------CDNHKI 1154
            ..||..|| :.....:....|:|...  ..:.|.|.|...|.::               .|..||
Mouse   790 RDGLLTPS-MSESDLTTSGRYRARRD--SVKKRPVSDLLSGKKSAVEGLPPLGGMKKTRADAKKI 851

  Fly  1155 GYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFY 1219
                |||        |:.|..|.     :....|:..:....|
Mouse   852 ----GPL--------KLAALNGL-----SLSRLPLPDEGKEVS---------------------- 877

  Fly  1220 KRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGR 1284
                   .:.|.|.|.        .|:||             ||   :....|:|....||....
Mouse   878 -------TRATNDERC--------KVLEQ-------------RL---EQGMVFTEYERILKKRLV 911

  Fly  1285 DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPRE--FIVTQGP 1347
            |..|:.|.||.|..:|||.::||||.:|.:|.|..:: .:.||||:::....|..|  :|.||||
Mouse   912 DGECSTARLPENAERNRFQDVLPYDDARVELVPTKEN-NTGYINASHIKVSVSGIEWDYIATQGP 975

  Fly  1348 LHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-----NDTVPVFYGDIKV--QILNDS 1405
            |.:|..|||:|.||.....|.|:|...|.||||..:|||     ::||.  ||..|:  :...||
Mouse   976 LQNTCQDFWQMVWEQGVAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVT--YGRFKITTRFRTDS 1038

  Fly  1406 H-YADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQR------- 1462
            . ||...:....|..|.| |.:.|..:|.||:.|.   |:.|..|: ::.:.|.:.:|
Mouse  1039 GCYATTGLKMKHLLTGQE-RTVWHLQYTDWPEHGC---PEDLKGFL-SYLEEIQSVRRHTNSTSE 1098

  Fly  1463 ------PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIH 1521
                  |::|||||||||:|..|..:.::..:..::.:||..::..:|::|:.:|||..||..::
Mouse  1099 PKSHNPPLLVHCSAGVGRTGVVILSEIMVACLEHNEVLDIPRVLDMLRQQRMMLVQTLGQYTFVY 1163

  Fly  1522 QCLLAVLEGKENI 1534
            :.|:..|:....|
Mouse  1164 RVLIQFLKSSRLI 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020	2/5 (40%)
		FN3	583..671	CDD:238020	15/89 (17%)
		fn3	683..753	CDD:278470	12/86 (14%)
		fn3	787..850	CDD:278470	19/102 (19%)
		fn3	866..935	CDD:278470	13/74 (18%)
		fn3	961..1043	CDD:278470	16/109 (15%)
		PTPc	1272..1525	CDD:214550	94/275 (34%)
		PTPc	1298..1525	CDD:238006	84/249 (34%)
Ptpn21	NP_001139671.1	B41	24..222	CDD:214604
		FERM_N	27..90	CDD:286467
		FERM_M	109..220	CDD:278785
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009	11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..703		4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..825		9/38 (24%)
		PTPc	898..1168	CDD:214550	95/277 (34%)
		PTPc	925..1168	CDD:238006	85/250 (34%)
		Substrate binding. /evidence=ECO:0000250	1110..1116		5/5 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910