DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and FNDC3A

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001073141.1	Gene:	FNDC3A / 22862	HGNCID:	20296	Length:	1198	Species:	Homo sapiens

Alignment Length:	1273	Identity:	252/1273 - (19%)
Similarity:	420/1273 - (32%)	Gaps:	370/1273 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 DNTFQHSVKELTPGATYQVQ----AYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVL 236
            |.|.|..:.::.||..:.::    .:....|...|...|.|.:..|                  :
Human    29 DGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPP------------------I 75

  Fly   237 WQPPYPA-------GIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQT 294
            :.||..|       |:.....|...|.....|...:.:...||.|      |.:|       |.|
Human    76 YVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLP------GFIP-------VPT 127

  Fly   295 MSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTV 359
            |      :|...::...|     ||...|..|  .:...:::.:...:.|.:          ||.
Human   128 M------MPPPPRHMYSP-----VTGAGDMTT--QYMPQYQSSQVYGDVDAH----------STH 169

  Fly   360 PRSNEPVAFFDFRDIAEPGKTFNVIVK-------TVSGKVTSWPATGDVTLRPLPVRN------- 410
            .|||       ||| ....||:..:.|       |...|::|.|::......|:...|
Human   170 GRSN-------FRD-ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQI 226

  Fly   411 ---------------------------------------LRSI-----NDDKTNTMIITW----- 426
                                                   |.:|     :|.:..|:::||
Human   227 AGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSS 291

  Fly   427 ----EADPASTQDEYRIVYHELETFNGD----TSTLTTDRTRFTLESLLPGRNYSLSVQAV--SK 481
                |.|.:|..:.|.  |..|.:..|.    .|....:.|..||..|.|..:|...|||.  |.
Human   292 LINGETDESSVPELYG--YEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSI 354

  Fly   482 KMESNETSIFVVTR-----PSSPIIEDLKSIRMGLNISWK--SDVNSKQEQYEVLYSR-NGTSDL 538
            |...:|..||....     |:.|.|.:  ..:..|.:.||  ||..||.:.:.:.:.. .|..:.
Human   355 KGTPSEAEIFTTLSCEPDIPNPPRIAN--RTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEF 417

  Fly   539 -RTQKTKESRLVIKNLQPGAGYELKVFA----VSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNS 598
             :.....:.:..|..|.|..|.:.::.|    .:.....|...|.....|:.|.:..:.......
Human   418 CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITW 482

  Fly   599 VLVHWSPPESGEFTEYSIRYRTDSEQQ---WVRLPSVRSTEADIT--DMTKGEKYTIQVNTVSFG 658
            :.:.||.| ||..::..|.|..:.|::   :...|.....:...|  ::.:..||..:|  :::.
Human   483 LSLQWSKP-SGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV--IAYN 544

  Fly   659 VESPV-PQEV--NTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILK-WW--PSDNPGRVQT 717
            .|... |.||  .||.|..|           .|.:: |..:|::.|:..| .|  |.||.|....
Human   545 SEGKSNPSEVVEFTTCPDKP-----------GIPVK-PSVKGKIHSHSFKITWDPPKDNGGATIN 597

  Fly   718 KNVSE-----NKSADDL----STVRVLIGELMPGVQYKFDIQTTSYGILSGIT-SLYPRTMPLIQ 772
            |.|.|     |.:..::    :|...|...|.||..|:..:...|.|..|.:: ||..:|..:..
Human   598 KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 662

  Fly   773 SDVVVANGEKEDERDTITLSY-TPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVP 836
            ...:....:...:...|.|.: .|.....|....|...:...|..:..::...::.:.|.:.|:|
Human   663 GPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727

  Fly   837 GRLYNITV----------WTVSGGVASLPIQRQDRLYPEPITQLHAT-----------NITD-TE 879
            |:.|:..:          ::....:.:.| ...|:..|..:|...||           |.|| ||
Human   728 GKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTE 791

  Fly   880 ISLRWDLPKGEYNDFDIAY----LTADNLLAQNMTTRNEITISDLRPHRNYTFTV----VVRSGT 936
            ..|.|.   |......|.|    |:.:              |..|.|...|...|    ||.:|.
Human   792 YRLEWG---GVEGSMQICYCGPGLSYE--------------IKGLSPATTYYCRVQALSVVGAGP 839

  Fly   937 ESSVLRSSSPLSASFTTNEAVPG-----------RVERFHPTDVQPSE-INFEWSLPSSEANGVI 989
            .|.|:...:|.|        |||           .:|..|   ..||. :...|..|....:.::
Human   840 FSEVVACVTPPS--------VPGIVTCLQEISDDEIENPH---YSPSTCLAISWEKPCDHGSEIL 893

  Fly   990 RQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREY--RQTMPI 1052
             .:||.:.:..:||...:..:       :|.||:|..||..:|||..::|.||....  .:|.|:
Human   894 -AYSIDFGDKQSLTVGKVTSY-------IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950

  Fly  1053 LAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQ 1117
              ||.|.                 |.....||.||.:::.              |...|..|...
Human   951 --PPDPP-----------------RLECVAFSHQNLKLKW--------------GEGTPKTLSTD 982

  Fly  1118 SYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTD 1182
            |         |..:...|:::....::....|..:|:...|    ..|:|:..::|       .:
Human   983 S---------IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLN----ESTSYKFCIQA-------CN 1027

  Fly  1183 TAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNM-------- 1239
            .|...|:..:       ...|.|.::...|               |..|..:.||::
Human  1028 EAGEGPLSQE-------YIFTTPKSVPAAL---------------KAPKIEKVNDHICEITWECL 1070

  Fly  1240 --SLPDSVIEQNRPILIKN--FAEHYRLMSADSDFRFS 1273
              ...|.||...:.:|.|:  |.:.|:  ..||.||:|
Human  1071 QPMKGDPVIYSLQVMLGKDSEFKQIYK--GPDSSFRYS 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	6/32 (19%)
		fn3	220..304	CDD:278470	15/90 (17%)
		fn3	315..391	CDD:278470	17/82 (21%)
		FN3	405..494	CDD:238020	30/154 (19%)
		FN3	511..574	CDD:238020	13/70 (19%)
		FN3	583..671	CDD:238020	20/95 (21%)
		fn3	683..753	CDD:278470	20/81 (25%)
		fn3	787..850	CDD:278470	11/73 (15%)
		fn3	866..935	CDD:278470	21/88 (24%)
		fn3	961..1043	CDD:278470	21/82 (26%)
		PTPc	1272..1525	CDD:214550	1/2 (50%)
		PTPc	1298..1525	CDD:238006
FNDC3A	NP_001073141.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..221		18/78 (23%)
		FN3	267..366	CDD:238020	27/100 (27%)
		FN3	371..462	CDD:238020	17/92 (18%)
		FN3	467..559	CDD:238020	19/94 (20%)
		FN3	564..657	CDD:238020	26/104 (25%)
		FN3	678..754	CDD:238020	11/75 (15%)
		FN3	756..848	CDD:238020	27/109 (25%)
		FN3	875..947	CDD:238020	19/79 (24%)
		FN3	952..1042	CDD:238020	21/147 (14%)
		FN3	1047..1144	CDD:238020	17/77 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910