DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and Ptprz1

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_006505075.1 Gene:Ptprz1 / 19283 MGIID:97816 Length:2318 Species:Mus musculus


Alignment Length:2141 Identity:465/2141 - (21%)
Similarity:765/2141 - (35%) Gaps:690/2141 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 AISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTH- 109
            |:||....|:::    .|||.......|..:....:...|.......||.:...:::|..:.|. 
Mouse   178 ALSILFEVGVEE----NLDYKAIIDGTESVSRFGKQAALDPFVLQNLLPNSTDKYYIYNGSLTSP 238

  Fly   110 --HDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTF 172
              .|.:.|.|...|.....|.|:|                       ..:||.:.:  |.|....
Mouse   239 PCTDTVEWIVFKDTVSISESQLAV-----------------------FCEVLTMQQ--SGYVMLM 278

  Fly   173 QVNDNTFQHSVKELTPGATYQVQAYTIYDGKESV-----AYTSRNFTTKPNTPGKFIVWFRNETT 232
            ....|.|:....:      :..|.::.|.|||.:     :....|....|          .|.|:
Mouse   279 DYLQNNFREQQYK------FSRQVFSSYTGKEEIHEVVCSSEPENVQADP----------ENYTS 327

  Fly   233 LLVLWQPP---YPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQT 294
            |||.|:.|   |.|.| ..:.|..:|...||...: |...:......|....|:|..:|.:.:..
Mouse   328 LLVTWERPRVVYDAMI-EKFAVLYQPLAGNDQAKH-EFLTDGYQDLGAILNNLLPNMSYVLQIVA 390

  Fly   295 MSEDE----------ISLPT-TAQYRTVP-----------------------LRPLNVTFDRDFI 325
            :..:.          :.:|| .|:....|                       |.|     .||.:
Mouse   391 VCSNGLYGKYSDQLIVDMPTEDAELDLFPELIGTEEIIKEEEYGKDNEEDTGLNP-----GRDSV 450

  Fly   326 TSNSFRVLWEAPKGISEFDKY-----QVSVATTRR----------QSTVPR-----SNEPVAFFD 370
            |:   ::..:.|: :|....|     :.:.|.|.|          :|.||.     :::.||.|:
Mouse   451 TN---QIRKKEPQ-VSTTTHYNHMGTKYNEAKTNRSPTRGSEFSGKSDVPNTSPNSTSQHVAEFE 511

  Fly   371 F-RDIAEPGKT-FNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIIT--WEADPA 431
            . |.|:.|.:| .|:....|.|...|. .:|..||...|..|| |...:..||:.||  .|....
Mouse   512 TERGISLPSQTGTNLPPHNVEGTSASL-NSGSKTLFIFPQMNL-SGTAESLNTVPITEYKEVSAD 574

  Fly   432 STQDEYRIVYHELETFNGDT--STLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVT 494
            .:::|..:...:|:|...|:  |:.:|....|:.::|..|  |..|       .:..|...:.|.
Mouse   575 VSEEENFLTDFKLDTGADDSSGSSPSTSTVPFSSDNLSHG--YITS-------SDMPEAITYDVL 630

  Fly   495 RPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGY 559
            :|.|.......|...|      |:.:.|....|......|::||.||.           :.|:|.
Mouse   631 KPGSTRNAPEDSAPSG------SEESLKDPSLEGSVWFPGSTDLTTQS-----------ETGSGR 678

  Fly   560 ELKVFAVSHDLR-SEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEF----TEYSIRYR 619
            |..:...|.|:: .|.....::..|:       .||..:..:.....|....|    ||.:.:..
Mouse   679 ESFLQVNSTDIQIDESRETTESFSPD-------ATVSQDPSVTDMGMPHYSTFAYLPTEVTPQAF 736

  Fly   620 TDSEQQWVRLPSVRSTEADITD-MTKGE-----KYTIQVNTVSFGVESPV---PQEVNTT----- 670
            |.|.:.....|::....:..|. :..||     .|:.:|    |.:.:|:   .|.:|||     
Mouse   737 TPSSRPLDLAPTINILHSQTTQPVYNGETPLQPSYSSEV----FPLATPLLLDNQTLNTTPAASS 797

  Fly   671 ----VPPNPVS--------NIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSEN 723
                :...|||        :|:...|...:.   |.......|.:.:...:.:....|..:.:|.
Mouse   798 SDSALHATPVSPSVGVSFESILSSYDDAPLL---PFSSASFSSEMFRHLHTVSQTLPQVTSAAER 859

  Fly   724 KSADDLS---TVRVLIGELM--PG-VQYKFDI-----------QTTSYGILSGI---TSLY---- 764
               |:||   ::.|..|:|:  |. |||. |:           .|..:|..|.:   ||:.    
Mouse   860 ---DELSLHASLLVARGDLLLEPSLVQYS-DVASHQATTRAASDTLGFGSESAVFYKTSMVSQIE 920

  Fly   765 -PRTMPLIQSDVVV---ANGEK-----EDERDTITLSYTPT------------------------ 796
             ||      ||||:   ::|.:     |......|:||:..                        
Mouse   921 SPR------SDVVMHAYSSGPEPSYTVEGSHHVPTVSYSSAMPLHGSVDVSDQGSLLINPSHISM 979

  Fly   797 PQSSSKFDIYRFSL--------GDAE----IRDKEKLANDTD--RKVTFTGLVPGRLYNITVWTV 847
            |:||  |.....||        ||.|    ..|.|.|..|.|  |.:..:..|....:..|....
Mouse   980 PESS--FITPTASLLQPPPALSGDGEWSGASSDSELLLPDADGLRTLNISSPVSVAEFTYTTSVF 1042

  Fly   848 SGGVASLPIQRQDRLYPEPITQLHATNITD-------------TEISLRWD-------------- 885
            :.|:.  |:.:.:.:|... |:|..::.:|             :::..:|.              
Mouse  1043 ADGIK--PLSKSEMMYGNE-TELKMSSFSDMAYPSKSTVVPKMSDVVHKWSESLKETSVSISSMK 1104

  Fly   886 --------------LPKGEYNDFDIAY----------LTADNLLAQNMTTRNEITISDLRPHRNY 926
                          ..:|..:..:|.:          .:.|..|...::..:|...||.....  
Mouse  1105 SVFPESLVYPTTKGFEQGVSHVPEIIFPVQPTHTASQASGDTWLKPGLSANSEAAFSDTASRE-- 1167

  Fly   927 TFTVVVRSGTESSVLRSSSP------LSASFTTNE----------AVPG--------RVER---- 963
                ||...|:..:..:::|      |..||..::          :||.        :||:    
Mouse  1168 ----VVHPSTQPLLYEAATPFNTEALLQPSFQASDVDTLLKTALPSVPSDPILAGTPQVEQSSSS 1228

  Fly   964 -FHP-------------------TDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQ 1008
             .||                   .|:.||:::   |.|       ::..::.::: ...::.|: 
Mouse  1229 VSHPMASESGSSESMLHFTSVPILDISPSKVH---STP-------LQGLTVPHSS-KKFSEQGL- 1281

  Fly  1009 DFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYR---- 1069
             .:|:....|:.:|...:.:........:..:.|:..:....|:|:...|...::...||.    
Mouse  1282 -LKSKSPQQVLPSLFSNDEFFQSAHLDVSQAYPPKGRHAFVTPVLSIDEPQNTLINKLVYSEDIF 1345

  Fly  1070 SSSTIQIRFR-----KNYFSD-----------QNGQVRMYTIIVAEDDAKNASGLEMPSW----- 1113
            ||:.|.|..:     ....||           .:|.:.:..:....||:...:.|.:||.     
Mouse  1346 SSTEISITDKVLTGLPTLASDVLSSTDHSVPLGSGPISLTMVSPNRDDSVTTAKLLLPSTATSKL 1410

  Fly  1114 ---------------------------LDVQSYSV-----WLPYQ-------------------A 1127
                                       :|...:.|     .|||:                   .
Mouse  1411 TQSARSDADLVGGGEDGDDYDDDDYDDIDRGRFPVNKCMSCLPYRESREKVMNDSDTQESSLVDQ 1475

  Fly  1128 IDPYYP--FENRSVEDFTIGTENCD----------NHKIGYCNGPLKSGT-----TYRVKVRAFT 1175
            .||..|  |||...|:...|....|          ||..|..:..::.|:     |...|..|..
Mouse  1476 SDPISPLLFENTEEENGGTGVTRVDKSPPPSMLPQNHNDGKEDSDIQMGSAVLPHTPGSKAWAVL 1540

  Fly  1176 GADK---------------FTDTAYSFP----------IQTDQ---------------------- 1193
            .:|:               .|.|.:|||          ::||.                      
Mouse  1541 TSDEESGSGQGTSDSLNDNETSTDFSFPDVNEKDTDGVLETDDTGIAPGSPRSSTPSVTSGHSGV 1605

  Fly  1194 DNTSLIVA--------------------ITVPLTII-------LVLLVTLLFYKRRRNNCRKTT- 1230
            .|:|...|                    ..:||.|:       ||:||.:|.|.|:   |.:|. 
Mouse  1606 SNSSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRK---CFQTAH 1667

  Fly  1231 ---KDSRANDNMSLPDSVI----EQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRD-QP 1287
               :|:.:...:|.|.:.|    :....|.||:|.:|...:.|.:.  |:||||.||...:: |.
Mouse  1668 FYLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKHVADLHASNG--FTEEFETLKEFYQEVQS 1730

  Fly  1288 CTFADL---------PCNRPKNRFTNILPYDHSRFKLQPVDDDEG--SDYINANYVPGHNSPREF 1341
            || |||         |.|:.|||:.||:.|||||.||..:.:.:|  :||||||||.|:|.|:.:
Mouse  1731 CT-ADLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINANYVDGYNRPKAY 1794

  Fly  1342 IVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDI-----KVQI 1401
            |..||||.||.:|||||.||.|...|||:|...||||.|||||||.|.... ||..     .||:
Mouse  1795 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDGSEE-YGSFLVNQKSVQV 1858

  Fly  1402 LNDSHYADWVMTEFM-----------LCRGSEQ-----RILRHFHFTTWPDFGVPNPPQTLVRFV 1450
            |     |.:.:..|.           |.:||::     |::..:|:|.|||.|||.....::.||
Mouse  1859 L-----AYYTVRNFTLRNTKLKKLSELFQGSQKGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAFV 1918

  Fly  1451 R----AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMV 1511
            |    |.|..:|    |:||||||||||:||:|.||.:||||.....|:|||.:..:|.:|.::|
Mouse  1919 RKAAQAKRHAVG----PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLV 1979

  Fly  1512 QTEQQYICIHQCLLAVLEGKENIVGPAREMHDN------EGYEGQQVQLDENGDVVATIEGHLSH 1570
            |||:||:.||..|:..:..||..| |...:|..      .|..| :.:|::...:::  :.::..
Mouse  1980 QTEEQYVFIHDTLVEAILSKETEV-PDSHIHSYVNTLLIPGPTG-KTKLEKQFQLLS--QSNILQ 2040

  Fly  1571 HDLQQAEAEAIDDEN--AAILHDDQQPLTSSFTGHHTHMPPTTSMSSFGGGGGGHTN----VDAP 1629
            .|...|..:...::|  ::|:     |:..|..|          :||..|.|..:.|    :...
Mouse  2041 SDYSTALKQCNREKNRTSSII-----PVERSRVG----------ISSLSGEGTDYINASYIMGYY 2090

  Fly  1630 DRXHSVVNQS--------------DNNNSVVIVLVD-------------NKPSSMICKDSK 1663
            .....::.|.              |:|..:|:::.|             ||...:.|:..|
Mouse  2091 QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFK 2151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 13/80 (16%)
fn3 220..304 CDD:278470 19/96 (20%)
fn3 315..391 CDD:278470 22/97 (23%)
FN3 405..494 CDD:238020 21/92 (23%)
FN3 511..574 CDD:238020 13/63 (21%)
FN3 583..671 CDD:238020 21/109 (19%)
fn3 683..753 CDD:278470 17/86 (20%)
fn3 787..850 CDD:278470 20/100 (20%)
fn3 866..935 CDD:278470 13/119 (11%)
fn3 961..1043 CDD:278470 13/105 (12%)
PTPc 1272..1525 CDD:214550 129/289 (45%)
PTPc 1298..1525 CDD:238006 114/253 (45%)
Ptprz1XP_006505075.1 alpha_CARP_receptor_like 45..298 CDD:239396 27/154 (18%)
fn3 313..395 CDD:365830 21/93 (23%)
PTP_DSP_cys 1714..1997 CDD:391942 130/293 (44%)
R-PTP-Z-2 2080..2283 CDD:350507 10/72 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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