DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptprs

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_006523937.1	Gene:	Ptprs / 19280	MGIID:	97815	Length:	1920	Species:	Mus musculus

Alignment Length:	1693	Identity:	419/1693 - (24%)
Similarity:	667/1693 - (39%)	Gaps:	354/1693 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVTITTAPDPP 126
            |.|..|| |:|       :.::|.::   :.:..|:....|...:......:||...........
Mouse   126 REDQLPP-GFP-------NIDMGPQL---KVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSA 179

  Fly   127 SNLSV-QVRSGKNAIILWSPPTQGSYTAFKIKVLGL--SEASSSYNRTFQVNDNTFQHSVKELTP 188
            ||..: |:|||...|.......||.|........|:  |..::.|.|..:        .|:.:.|
Mouse   180 SNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELR--------EVRRVAP 236

  Fly   189 GATYQVQAYTIYDGKESVAYTSRNFT-TKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVS 252
            ..:....::.|..|      .:.|.| ....:|..::.|.:....|..  :...|.|     :..
Mouse   237 RFSILPMSHEIMPG------GNVNITCVAVGSPMPYVKWMQGAEDLTP--EDDMPVG-----RNV 288

  Fly   253 IEPPDANDSVLY----VEKEGEPPGPAQAAFKGL--VPGRAYNISVQTMSEDEISLPTTAQYRTV 311
            :|..|..||..|    :...|.....||...|.|  .||                         .
Mouse   289 LELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPG-------------------------T 328

  Fly   312 PLRPLNVTFDRDFITSNSFRVLWEAP------------KGISEFDKYQV--SVATTRRQ--STVP 360
            |:...|        |:.|..|.|::.            |..|:...||:  .:.|||..  ...|
Mouse   329 PVVTEN--------TATSITVTWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSP 385

  Fly   361 RSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIIT 425
            .|...:.......|.:...:.:|:.:|  |:.....|..:|..|.|           ...|||:.
Mouse   386 NSEYEIWVSAVNSIGQGPPSESVVTRT--GEQAPASAPRNVQARML-----------SATTMIVQ 437

  Fly   426 WE--ADPASTQDEYRIVY-----HEL---ETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVS 480
            ||  .:|......||:.|     |.:   :..|.|.|.||      |:.|||....|::.|.|.:
Mouse   438 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT------TVGSLLEDETYTVRVLAFT 496

  Fly   481 KKMESN-ETSIFVVTR---PSSP--IIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLR 539
            ...:.. ...|.|.|:   |..|  :..:.|| ...:.:||.:.......:||:|: |.|.....
Mouse   497 SVGDGPLSDPIQVKTQQGVPGQPMNLRAEAKS-ETSIGLSWSAPRQESVIKYELLF-REGDRGRE 559

  Fly   540 TQKTKE--SRLVIKNLQPGAGYELKVFAVS-------------HDLRSEPHAYFQAVYPNPPRNM 589
            ..:|.:  :..|:::|:|...|..::.|.|             ..|:::|.|        ||:::
Mouse   560 VGRTFDPTTAFVVEDLKPNTEYAFRLAARSPQGLGAFTAVVRQRTLQAKPSA--------PPQDV 616

  Fly   590 TIETVRSNSVLVHWSPP----ESGEFTEYSIRYR----TDSEQQWVRLPSVRSTEADITDMTKGE 646
            ...::||.::||.|.||    .:|....||:|||    .|.:.:.|......:|:..:..:.|..
Mouse   617 KCTSLRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWT 681

  Fly   647 KYTIQVNTVSF-----GVE-SPVPQEVNTTVPPNPVSNI-IQLVDSRNITLEWPKP-----EGRV 699
            :|  :|..|::     |.| |||....:..||..|...: .:.:::..|.:.|..|     .|::
Mouse   682 EY--RVTAVAYTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPTPGRQHGQI 744

  Fly   700 ESYILKWWPSD-----NPGRVQTKNVSENK-SADDLSTVRVLIGELMPGVQYKFDIQTTSYGILS 758
            ..|.:.:...:     .|.|::...:::.: ..||.:...::|..|.|...|  .|...:|.:..
Mouse   745 RGYQVHYVRMEGAEARGPPRIKDIMLADAQWEMDDTAEYEMVITNLQPETAY--SITVAAYTMKG 807

  Fly   759 GITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTP---------TPQSSSKFDI--YRFSLG- 811
            ......|:        |||..|.... |.|:::..||         .|..:::..:  ||...|
Mouse   808 DGARSKPK--------VVVTKGAVLG-RPTLSVQQTPEGSLLARWEPPADAAEDPVLGYRLQFGR 863

  Fly   812 -DAEIRDKE------KLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQ 869
             ||.....|      :.|....:..|:...:..| ....:...:....|:| :...|.:|:.:..
Mouse   864 EDAAPATLELAAWERRFAAPAHKGATYVFRLAAR-GRAGLGEEAAAALSIP-EDAPRGFPQILGA 926

  Fly   870 LHATNITDTEISLRWDLP--KGEYNDFDIAY-LTADNLLAQNMTTRNE------------ITISD 919
              |.|::...:.||| ||  ..|.|...|.| ::.....|....|..|            :|:..
Mouse   927 --AGNVSAGSVLLRW-LPPVPAERNGAIIKYTVSVREAGAPGPATETELAAAAQPGAETALTLRG 988

  Fly   920 LRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSE 984
            |||...|...  ||:.|.......|.||......:...|   :.|....:..:.:...|..|.:.
Mouse   989 LRPETAYELR--VRAHTRRGPGPFSPPLRYRLARDPVSP---KNFKVKMIMKTSVLLSWEFPDNY 1048

  Fly   985 ANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVF--------------KIQAK 1035
            .:..  .:.|.|   |.||    .|.:......:|.:|||...|.|              .:.|:
Mouse  1049 NSPT--PYKIQY---NGLT----LDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAR 1104

  Fly  1036 TAIGFGPEREYRQTMPILAPPRPATQ---VVPTEVYRSSSTIQIRFRKNYF-------SDQNGQV 1090
            ||...      ....|.:| |:|...   ||.....:|..|:|     |||       ..:.||
Mouse  1105 TAFNM------LSGKPSVA-PKPDNDGFIVVYLPDGQSPVTVQ-----NYFIVMVPLRKSRGGQ- 1156

  Fly  1091 RMYTIIVA-------EDDAKNASGLEMPSWLDVQSYSVWLPYQA----IDP--YYPFENRSVEDF 1142
              :.:::.       |:..::.|.|:..|....:...|..||.|    |.|  ::|...:...
Mouse  1157 --FPVLLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSILPAVFHPGNQKQYG-- 1217

  Fly  1143 TIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADK--FTDTAYSFPIQTD----------QDN 1195
                        |:.|..|:.|..|.:.|.|....::  |..:.:|.|.|.|          ::.
Mouse  1218 ------------GFDNRGLEPGHRYVLFVLAVLQKNEPTFAASPFSDPFQLDNPDPQPIVDGEEG 1270

  Fly  1196 TSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRAN-----DNMSL----PDSVIEQNR- 1250
            ...::...:.:..|:.:::.:|.||.:.::.|   |||...     :|..|    |...:|..|
Mouse  1271 LIWVIGPVLAVVFIICIVIAILLYKNKPDSKR---KDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1332

  Fly  1251 -----------PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTN 1304
                       ||.|.:.|||...:.|:...:.|:|:|.: ..|:......::|..|:||||:.|
Mouse  1333 NFQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEANKPKNRYAN 1396

  Fly  1305 ILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVM 1369
            ::.|||||..|||::...||||||||||.|:.....:|.|||||..|..|||||.||..|..:||
Mouse  1397 VIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATVVM 1461

  Fly  1370 LTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFT 1432
            :||..||.|.||||||||..... ||.|:|.:|:....|.:.:..|.|.:  .||:|.:|||.||
Mouse  1462 MTRLEEKSRIKCDQYWPNRGTET-YGFIQVTLLDTMELATFCVRTFSLHKNGSSEKREVRHFQFT 1525

  Fly  1433 TWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIF 1497
            .|||.|||..|...:.|:|..:.....:..||||||||||||:|.||.:|.:|::|.|...||::
Mouse  1526 AWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKTEKTVDVY 1590

  Fly  1498 GIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVA 1562
            |.|..||.:|.:|||||.||..||:.||..: |..|...|||.::.   |..:..|: |.|:.|.
Mouse  1591 GHVTLMRSQRNYMVQTEDQYGFIHEALLEAV-GCGNTEVPARSLYT---YIQKLAQV-EPGEHVT 1650

  Fly  1563 TIE 1565
            .:|
Mouse  1651 GME 1653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	18/83 (22%)
		fn3	220..304	CDD:278470	17/89 (19%)
		fn3	315..391	CDD:278470	17/91 (19%)
		FN3	405..494	CDD:238020	25/99 (25%)
		FN3	511..574	CDD:238020	15/77 (19%)
		FN3	583..671	CDD:238020	27/101 (27%)
		fn3	683..753	CDD:278470	14/80 (18%)
		fn3	787..850	CDD:278470	13/81 (16%)
		fn3	866..935	CDD:278470	21/83 (25%)
		fn3	961..1043	CDD:278470	18/95 (19%)
		PTPc	1272..1525	CDD:214550	120/254 (47%)
		PTPc	1298..1525	CDD:238006	114/228 (50%)
Ptprs	XP_006523937.1	I-set	33..124	CDD:400151
		Ig strand A	33..36	CDD:409353
		Ig strand A'	42..45	CDD:409353
		Ig strand B	50..57	CDD:409353
		Ig strand C	63..68	CDD:409353
		Ig strand C'	71..73	CDD:409353
		Ig strand D	80..84	CDD:409353
		Ig strand E	86..93	CDD:409353
		Ig strand F	103..111	CDD:409353
		Ig strand G	114..124	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	137..226	CDD:409400	18/91 (20%)
		Ig strand B	152..156	CDD:409400	0/3 (0%)
		Ig strand C	165..169	CDD:409400	1/3 (33%)
		Ig strand E	190..194	CDD:409400	1/3 (33%)
		Ig strand F	204..209	CDD:409400	1/4 (25%)
		Ig strand G	216..219	CDD:409400	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401	17/93 (18%)
		Ig strand B	253..257	CDD:409401	1/3 (33%)
		Ig strand C	266..270	CDD:409401	0/3 (0%)
		Ig strand E	287..291	CDD:409401	0/3 (0%)
		Ig strand F	299..304	CDD:409401	1/4 (25%)
		Ig strand G	312..315	CDD:409401	0/2 (0%)
		FN3	323..412	CDD:238020	19/121 (16%)
		FN3	419..511	CDD:238020	28/108 (26%)
		FN3	516..604	CDD:238020	18/89 (20%)
		FN3	612..706	CDD:238020	27/95 (28%)
		FN3	714..819	CDD:238020	19/114 (17%)
		FN3	929..1017	CDD:238020	24/90 (27%)
		FN3	1022..1105	CDD:238020	17/94 (18%)
		PTP_tm	<1211..1295	CDD:408631	14/97 (14%)
		R-PTPc-S-1	1342..1623	CDD:350473	129/283 (46%)
		R-PTP-S-2	1625..1914	CDD:350475	10/33 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940