DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and Ptprs

DIOPT Version :10

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:NP_035348.2 Gene:Ptprs / 19280 MGIID:97815 Length:1907 Species:Mus musculus


Alignment Length:1743 Identity:417/1743 - (23%)
Similarity:646/1743 - (37%) Gaps:500/1743 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 LKDVRCADLAISIPNNPGLDDGA-------SYRLDYSPPFGYPEPNTTIASREIGDEIQFS---- 90
            :|.:|..  |:.|.::...|.|.       |..:.||.|     .|..:..|.:..  :||    
Mouse   184 IKQLRSG--ALQIESSEETDQGKYECVATNSAGVRYSSP-----ANLYVRVRRVAP--RFSILPM 239

  Fly    91 --RALPGTKYNFWLYYTN--FTHHDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSY 151
              ..:||...|.......  ..:..|:.....:|...|.|        .|:|.:.|.......:|
Mouse   240 SHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMP--------VGRNVLELTDVKDSANY 296

  Fly   152 TAFKIKVLGLSEASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTK 216
            |...:..||:.||.:             |.:||.|                              
Mouse   297 TCVAMSSLGVIEAVA-------------QITVKSL------------------------------ 318

  Fly   217 PNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKG 281
            |..||..:|.....|::.|.|....|                 |.|.|                 
Mouse   319 PKAPGTPVVTENTATSITVTWDSGNP-----------------DPVSY----------------- 349

  Fly   282 LVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKY 346
                  |.|..::.|:|               .|..:..|   ||:..:.:     .|:|...:|
Mouse   350 ------YVIEYKSKSQD---------------GPYQIKED---ITTTRYSI-----GGLSPNSEY 385

  Fly   347 QVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNL 411
            ::.|:........|.|.                  :|:.:|  |:.....|..:|..|.|     
Mouse   386 EIWVSAVNSIGQGPPSE------------------SVVTRT--GEQAPASAPRNVQARML----- 425

  Fly   412 RSINDDKTNTMIITWE--ADPASTQDEYRIVY-----HEL---ETFNGDTSTLTTDRTRFTLESL 466
                  ...|||:.||  .:|......||:.|     |.:   :..|.|.|.||      |:.||
Mouse   426 ------SATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT------TVGSL 478

  Fly   467 LPGRNYSLSVQAVSKKMESN-ETSIFVVTR---PSSP--IIEDLKSIRMGLNISWKSDVNSKQEQ 525
            |....|::.|.|.:...:.. ...|.|.|:   |..|  :..:.|| ...:.:||.:.......:
Mouse   479 LEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAKS-ETSIGLSWSAPRQESVIK 542

  Fly   526 YEVLYSRNGTSDLRTQKTKE--SRLVIKNLQPGAGYELKVFAVS-------------HDLRSEPH 575
            ||:|: |.|.......:|.:  :..|:::|:|...|..::.|.|             ..|:::|.
Mouse   543 YELLF-REGDRGREVGRTFDPTTAFVVEDLKPNTEYAFRLAARSPQGLGAFTAVVRQRTLQAKPS 606

  Fly   576 AYFQAVYPNPPRNMTIETVRSNSVLVHWSPP----ESGEFTEYSIRYRTDSEQQWVRLPSVRSTE 636
            |        ||:::...::||.::||.|.||    .:|....||:|||                 
Mouse   607 A--------PPQDVKCTSLRSTAILVSWRPPPPETHNGALVGYSVRYR----------------- 646

  Fly   637 ADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEW--------- 692
                               ..|.|.|.|:||| .:||.....:::.::      :|         
Mouse   647 -------------------PLGSEDPDPKEVN-NIPPTTTQILLEALE------KWTEYRVTAVA 685

  Fly   693 -----PKPEG-----RVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKF 747
                 |.||.     |.:..:    ||..|.:|:.:       |.:.:.:|||.....||.|:. 
Mouse   686 YTEVGPGPESSPVVVRTDEDV----PSAPPRKVEAE-------ALNATAIRVLWRSPTPGRQHG- 738

  Fly   748 DIQTTSYGI----LSG---------------------ITSLYPRTMPLI--------------QS 773
              |...|.:    :.|                     ||:|.|.|...|              :.
Mouse   739 --QIRGYQVHYVRMEGAEARGPPRIKDIMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKP 801

  Fly   774 DVVVANGEKEDERDTITLSYTP---------TPQSSSKFDI--YRFSLG--DAEIRDKE------ 819
            .|||..|.... |.|:::..||         .|..:::..:  ||...|  ||.....|      
Mouse   802 KVVVTKGAVLG-RPTLSVQQTPEGSLLARWEPPADAAEDPVLGYRLQFGREDAAPATLELAAWER 865

  Fly   820 KLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRW 884
            :.|....:..|:...:..| ....:...:....|:| :...|.:|:.:..  |.|::...:.|||
Mouse   866 RFAAPAHKGATYVFRLAAR-GRAGLGEEAAAALSIP-EDAPRGFPQILGA--AGNVSAGSVLLRW 926

  Fly   885 DLP--KGEYNDFDIAY-LTADNLLAQNMTTRNE------------ITISDLRPHRNYTFTVVVRS 934
             ||  ..|.|...|.| ::.....|....|..|            :|:..|||...|...  ||:
Mouse   927 -LPPVPAERNGAIIKYTVSVREAGAPGPATETELAAAAQPGAETALTLRGLRPETAYELR--VRA 988

  Fly   935 GTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNI 999
            .|.......|.||......:...|   :.|....:..:.:...|..|.:..:..  .:.|.|   
Mouse   989 HTRRGPGPFSPPLRYRLARDPVSP---KNFKVKMIMKTSVLLSWEFPDNYNSPT--PYKIQY--- 1045

  Fly  1000 NNLTDAGMQDFESEEAFGVIKNLKPGETYVF--------------KIQAKTAIGFGPEREYRQTM 1050
            |.||    .|.:......:|.:|||...|.|              .:.|:||...      ....
Mouse  1046 NGLT----LDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTARTAFNM------LSGK 1100

  Fly  1051 PILAPPRPATQ---VVPTEVYRSSSTIQIRFRKNYF-------SDQNGQVRMYTIIVA------- 1098
            |.:| |:|...   ||.....:|..|:|     |||       ..:.||   :.:::.       
Mouse  1101 PSVA-PKPDNDGFIVVYLPDGQSPVTVQ-----NYFIVMVPLRKSRGGQ---FPVLLGSPEDMDL 1156

  Fly  1099 EDDAKNASGLEMPSWLDVQSYSVWLPYQA----IDP--YYPFENRSVEDFTIGTENCDNHKIGYC 1157
            |:..::.|.|:..|....:...|..||.|    |.|  ::|...:...              |:.
Mouse  1157 EELIQDISRLQRRSLRHSRQLEVPRPYIAARFSILPAVFHPGNQKQYG--------------GFD 1207

  Fly  1158 NGPLKSGTTYRVKVRAFTGADK--FTDTAYSFPIQTD----------QDNTSLIVAITVPLTIIL 1210
            |..|:.|..|.:.|.|....::  |..:.:|.|.|.|          ::....::...:.:..|:
Mouse  1208 NRGLEPGHRYVLFVLAVLQKNEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFII 1272

  Fly  1211 VLLVTLLFYKRRRNNCRKTTKDSRAN-----DNMSL----PDSVIEQNR------------PILI 1254
            .:::.:|.||.:.::.|   |||...     :|..|    |...:|..|            ||.|
Mouse  1273 CIVIAILLYKNKPDSKR---KDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPI 1334

  Fly  1255 KNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVD 1319
            .:.|||...:.|:...:.|:|:|.: ..|:......::|..|:||||:.|::.|||||..|||::
Mouse  1335 TDMAEHMERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEANKPKNRYANVIAYDHSRVILQPLE 1398

  Fly  1320 DDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQY 1384
            ...||||||||||.|:.....:|.|||||..|..|||||.||..|..:||:||..||.|.|||||
Mouse  1399 GIMGSDYINANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATVVMMTRLEEKSRIKCDQY 1463

  Fly  1385 WPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLV 1447
            |||..... ||.|:|.:|:....|.:.:..|.|.:  .||:|.:|||.||.|||.|||..|...:
Mouse  1464 WPNRGTET-YGFIQVTLLDTMELATFCVRTFSLHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFL 1527

  Fly  1448 RFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQ 1512
            .|:|..:.....:..||||||||||||:|.||.:|.:|::|.|...||::|.|..||.:|.:|||
Mouse  1528 AFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKTEKTVDVYGHVTLMRSQRNYMVQ 1592

  Fly  1513 TEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVATIE 1565
            ||.||..||:.||..: |..|...|||.::.   |..:..|: |.|:.|..:|
Mouse  1593 TEDQYGFIHEALLEAV-GCGNTEVPARSLYT---YIQKLAQV-EPGEHVTGME 1640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:394996 15/80 (19%)
fn3 220..304 CDD:394996 14/83 (17%)
FN3 278..>734 CDD:442628 101/509 (20%)
FN3 583..671 CDD:238020 22/91 (24%)
fn3 787..850 CDD:394996 13/81 (16%)
fn3 866..935 CDD:394996 21/83 (25%)
fn3 959..1043 CDD:394996 18/97 (19%)
PTP_tm 1083..1187 CDD:465889 22/125 (18%)
R3-PTPc 1301..1522 CDD:350396 110/222 (50%)
PtprsNP_035348.2 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409570
Ig strand C 63..67 CDD:409570
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000269|PubMed:19833921, ECO:0000269|PubMed:21454754 68..72
Ig strand E 86..93 CDD:409570
Ig strand F 104..109 CDD:409570
Ig strand G 117..120 CDD:409570
IgI_2_RPTP_IIa_LAR_like 137..226 CDD:409400 11/48 (23%)
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400 1/2 (50%)
Ig strand E 190..195 CDD:409400 1/6 (17%)
Ig strand F 204..211 CDD:409400 0/6 (0%)
Ig strand G 214..225 CDD:409400 4/15 (27%)
IgI_3_RPTP_IIa_LAR_like 235..316 CDD:409401 18/101 (18%)
Ig strand A 235..237 CDD:409401 1/1 (100%)
Ig strand A' 241..245 CDD:409401 0/3 (0%)
Ig strand B 248..256 CDD:409401 1/7 (14%)
Ig strand C 261..267 CDD:409401 1/5 (20%)
Ig strand C' 269..271 CDD:409401 0/1 (0%)
Ig strand D 274..278 CDD:409401 0/3 (0%)
Ig strand E 283..288 CDD:409401 1/4 (25%)
Ig strand F 295..302 CDD:409401 2/6 (33%)
Ig strand G 306..315 CDD:409401 3/21 (14%)
FN3 309..815 CDD:442628 137/716 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..711 6/23 (26%)
FN3 916..1004 CDD:238020 24/90 (27%)
FN3 1009..1092 CDD:238020 17/94 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1286..1313 7/29 (24%)
R-PTPc-S-1 1329..1610 CDD:350473 129/283 (46%)
R-PTP-S-2 1612..1901 CDD:350475 10/33 (30%)
Blue background indicates that the domain is not in the aligned region.

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