DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptprn

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_033011.2	Gene:	Ptprn / 19275	MGIID:	102765	Length:	981	Species:	Mus musculus

Alignment Length:	691	Identity:	174/691 - (25%)
Similarity:	268/691 - (38%)	Gaps:	152/691 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 EAVPGRVERFHPTDVQPSEINFEWSLPSSEANGV-IR-----QFSIAYT-----------NINNL 1002
            |.:.||.|:..|...|| |::.:.........|| :|     |||...|           |:...
Mouse   316 EVLGGRGEKSPPQAAQP-ELSLQRLTAVLAGYGVELRQLTPEQFSTLLTLLQLLPKGTGRNLEGA 379

  Fly  1003 TDAG----------MQDFESEEAFGVIKNLKPGETYV------FKIQAKTAIGFGPEREYR---- 1047
            .:.|          ||..:..||.....:| ||  |:      .::|...:.|| ||..:.
Mouse   380 VNVGGADVKKTIQQMQRGDPAEALPPTPSL-PG--YLTASPASSEVQQVLSPGF-PEPPHTPSPL 440

  Fly  1048 -QTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQN-----GQVRMYTIIVAEDDAKNAS 1106
             .:..:|....|..|..||.|.|.|:...........:||.     ..||:..|:.  :....:|
Mouse   441 GSSSVLLEKKSPLGQSQPTVVGRPSARPSAEEYGYIVTDQKPLSLVAGVRLLEILA--EHVHMSS 503

  Fly  1107 GLEMPSWLDVQSYSVWLPYQAIDPYYPF------ENRSVEDFTIGTENCDNHKIGYCNGPLKSGT 1165
            |    |::::         ..:.|...|      :|.|:.|.|        .:.|.....|::.|
Mouse   504 G----SFINI---------SVVGPAVTFRIRHNEQNLSLADVT--------QQAGLVKSELEAQT 547

  Fly  1166 TYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAIT-VPLTIILVLLVTLLFYKRRRNNCRKT 1229
            ..::   ..||..:..:.|...|.|....:....|.:| |.|..:..|||.|......|::.|:.
Mouse   548 GLQI---LQTGVGQREEAAEVLPRQAHGISPMRSVLLTLVALAGVAGLLVALAVALCMRHHSRQR 609

  Fly  1230 TKD---------SRANDNMSLPDSVIEQNRPILIKNFAEHY----RLMSADSDF----------- 1270
            .|:         :..:......|...:......:.|.||..    |:.|..|.|
Mouse   610 DKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGQPEPSRVSSVSSQFSDAAQASPSSH 674

  Fly  1271 -----------------------------------RFSEEFEEL-KHVGRDQPCTFADLPCNRPK 1299
                                               |.::|::.| .:......|..|....|..|
Mouse   675 SSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCAAAQDESNIKK 739

  Fly  1300 NRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPR--EFIVTQGPLHSTRDDFWRMCWES 1362
            ||..:.|||||:|.||:.......||||||:.:..|: ||  .:|.|||||..|..|||:|.|||
Mouse   740 NRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHD-PRMPAYIATQGPLSHTIADFWQMVWES 803

  Fly  1363 NSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYA-DWVMTEFML--CRGSEQR 1424
            ....|||||...|.|.::||:||| |.....|...:|.::::..:. |:::..|.|  .:..|.|
Mouse   804 GCTVIVMLTPLVEDGVKQCDRYWP-DEGSSLYHVYEVNLVSEHIWCEDFLVRSFYLKNLQTQETR 867

  Fly  1425 ILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN 1489
            .|..|||.:||..|.|...:.|:.|.|...........||:||||.|.||:||:|.:|.:|.::.
Mouse   868 TLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMA 932

  Fly  1490 TS-DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE 1529
            .. ..:||...:..:|.:|..:|:::.|:   ...|.||.|
Mouse   933 KGVKEIDIAATLEHVRDQRPGLVRSKDQF---EFALTAVAE 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470	25/114 (22%)
		PTPc	1272..1525	CDD:214550	90/259 (35%)
		PTPc	1298..1525	CDD:238006	85/232 (37%)
Ptprn	NP_033011.2	RESP18 homology domain. /evidence=ECO:0000250\|UniProtKB:Q16849	38..134
		RESP18	63..141	CDD:291609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..332		5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..445		13/54 (24%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250\|UniProtKB:Q16849	451..577		29/151 (19%)
		Receptor_IA-2	474..559	CDD:288410	19/110 (17%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250\|UniProtKB:P80560	603..734		16/130 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..682		6/35 (17%)
		PTPc	711..970	CDD:214550	93/263 (35%)
		PTPc	738..970	CDD:238006	88/236 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910