DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprj

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_006499054.1	Gene:	Ptprj / 19271	MGIID:	104574	Length:	1351	Species:	Mus musculus

Alignment Length:	1394	Identity:	377/1394 - (27%)
Similarity:	576/1394 - (41%)	Gaps:	287/1394 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 VEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVP--------LRPL----- 316
            :|.|...||....|  |.|||        |....:...|...:.||.|        |.||
Mouse    87 LETETRAPGFGHTA--GRVPG--------TFQGAQGMKPAARETRTPPRSPGLRWALLPLLLLLR 141

  Fly   317 -----------NVTFDRDFITS-NSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSN--EPVA 367
                       |..||.:.:.| .|..:.|          |:..|.|:..|......||  .||.
Mouse   142 QGQVLCAGAAPNPIFDIEAVVSPTSVLLTW----------KHNDSGASECRIENKMESNLTFPVK 196

  Fly   368 FFDFRDIA--EPGK--TFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEA 428
            .....:|.  .||.  ||::|..|     |:......:|..|.||.:|...:...|... :||
Mouse   197 NQTSCNITGLSPGTSYTFSIISVT-----TNETLNKTITTEPWPVSDLHVTSVGVTQAR-LTW-- 253

  Fly   429 DPASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSI-FV 492
            ..|:....||::..||           |..:...:..|.||.|.|.:..      |||||.. |.
Mouse   254 SNANGTASYRMLIEEL-----------TTHSSVNISGLKPGTNNSFAFP------ESNETQADFA 301

  Fly   493 VTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRL---VIKNLQ 554
            |..                               ||....|||.  |...|..|:|   .:.::.
Mouse   302 VAE-------------------------------EVPADANGTK--RIPVTNLSQLHKNSLVSVD 333

  Fly   555 PGAGY-----ELKVFAVSHDLRSEPHAYFQAV--YPNPPRNMTIET------------VRSNSVL 600
            |.:|.     |:.:..:..|.:.....|.||.  ....|||...:|            :.::|:.
Mouse   334 PPSGQDPSLTEILLTDLKPDTQYNATIYSQAANGTEGQPRNKVFKTNSTQVSDVRAMNISASSMT 398

  Fly   601 VHWSPPESGEFTEYSIRYR------TDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGV 659
            :.|.....|..|  ||.|:      |.|..|     :|..|||.|..::....|.|.|:.. .|.
Mouse   399 LTWKSNYDGSRT--SIVYKIHVAGGTHSVNQ-----TVNKTEAIILGLSSSTLYNITVHPF-LGQ 455

  Fly   660 ESPVPQEVNTTVPPNPVSNI-IQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSEN 723
            ....|..:.....|:.||:. :..|.:|.|.|.|...:.:.....:|     ..|..:.:|.|..
Mouse   456 TEGTPGFLQVYTSPDQVSDFRVTNVSTRAIGLAWRSNDSKSFEIFIK-----QDGGEKHRNASTG 515

  Fly   724 KSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITS-LYPRTMPLIQSDVVVANGEKEDERD 787
            ..:       .::.:|.||..|.|:|.........|::| :...|.|...:|:.|.|....:
Mouse   516 NQS-------YMVEDLKPGTSYHFEIIPRGPDGTEGLSSTVNGSTDPSAVTDIRVVNISTTE--- 570

  Fly   788 TITLSYTPTPQSSS-KFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVW----TV 847
             :.|.:..|..:|. .:.:...|...:.||     .|.:.:.:|...|.||.|||:|::    .:
Mouse   571 -MQLEWQNTDDASGYTYHLVLESKSGSIIR-----TNSSQKWITVGSLTPGTLYNVTIFPEVDQI 629

  Fly   848 SGGVASLPIQRQDRLYPEPITQLH-ATNITDTEISLRW---DLPKGEYNDFDIAYLTAD-NLLAQ 907
            .|      |......|..|.:..| ..|.|.|..::||   |.....|....:...|.| :.:..
Mouse   630 QG------ISNSITQYTRPSSVSHIEVNTTTTTAAIRWKNEDAASASYAYSVLILKTGDGSNVTS 688

  Fly   908 NMTTRNEITISDLRPHRNYTFTVV--VRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQ 970
            |.|....|.|.:|.|..:||..::  |..||.|.|     |....|.|.   |..|..|| .:|.
Mouse   689 NFTKDPSILIPELIPGVSYTVKILTQVGDGTTSLV-----PGWNLFCTE---PEPVTSFH-CEVV 744

  Fly   971 PSE--INFEWSLPSSEANGVIRQFSIA--------YTNINNLTDAGMQDFESEEAFGVIKNLKPG 1025
            |.|  :..:|:.|.    |:...|.:.        .|.:.|.|.....:..:|.|:     |...
Mouse   745 PKEPALVLKWACPF----GMYTGFELGVRSDSWDNMTRLENCTSDDDTECRTEVAY-----LNFS 800

  Fly  1026 ETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQV 1090
            .:|...|...:........:...|..|..||.|......|.|  |.::::::|  :.|...:|.:
Mouse   801 TSYNISIATLSCGKMALPAQNICTTGITDPPTPDGSPNITSV--SHNSVKVKF--SGFEASHGPI 861

  Fly  1091 RMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQ-----AIDPYYPFENRSVE---------- 1140
            :.|.:|:...:|...|.       ||..|:    |:     |.|.|..:..|..|
Mouse   862 KAYAVILTTGEAAQPSA-------DVLKYT----YEDFKRGASDTYVTYLIRIEEKGQSQGLSEV 915

  Fly  1141 ---DFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFT-------------GADKFTD-TAYSFP 1188
               :..:|.::.   .:||.||.|:...:||..|..||             |.:.:.. :.||..
Mouse   916 LNYEIDVGNQST---TLGYYNGRLEPLGSYRACVAGFTNITYNLQNDGLINGDESYVSFSPYSEA 977

  Fly  1189 IQTDQDNTSLIVAITVPLTIILVLLVT----LLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQN 1249
            :...||..  ::...|...|...|.:|    .:|::::|.:.:        |:.:|......:::
Mouse   978 VFLPQDPG--VICGAVFGCIFGALAITAVGGFIFWRKKRTDAK--------NNEVSFSQIKPKKS 1032

  Fly  1250 RPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFK 1314
            :.|.::||..:::...|||:..|:||:|:||.:|...|...|::..||.|||:.|:||||.||.|
Mouse  1033 KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYTAEIAENRGKNRYNNVLPYDISRVK 1097

  Fly  1315 LQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGRE 1379
            |. |......|||||||:||::|.::||.|||||.:|..|||||.||.|..||||||:|.|:||.
Mouse  1098 LS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQGRT 1161

  Fly  1380 KCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML--CRGSEQRILRHFHFTTWPDFGVPNP 1442
            ||::|||:.... .||||.|.:.::....:|.:.:|::  .:.||...||.||||:|||.|||:.
Mouse  1162 KCEEYWPSKQAQ-DYGDITVAMTSEVVLPEWTIRDFVVKNMQNSESHPLRQFHFTSWPDHGVPDT 1225

  Fly  1443 PQTLVRF---VRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMR 1504
            ...|:.|   ||.:..:|..|. ||:|||||||||:||||.:||::.||...:.||::||||.:|
Mouse  1226 TDLLINFRYLVRDYMKQIPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLR 1289

  Fly  1505 KERVWMVQTEQQYICIHQCLLAVLEGKEN 1533
            ..|..|||||.||:.::||:|.::..:::
Mouse  1290 MHRPLMVQTEDQYVFLNQCVLDIIRAQKD 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470	10/38 (26%)
		fn3	315..391	CDD:278470	23/98 (23%)
		FN3	405..494	CDD:238020	24/89 (27%)
		FN3	511..574	CDD:238020	13/70 (19%)
		FN3	583..671	CDD:238020	24/105 (23%)
		fn3	683..753	CDD:278470	15/69 (22%)
		fn3	787..850	CDD:278470	15/67 (22%)
		fn3	866..935	CDD:278470	20/75 (27%)
		fn3	961..1043	CDD:278470	18/91 (20%)
		PTPc	1272..1525	CDD:214550	128/257 (50%)
		PTPc	1298..1525	CDD:238006	117/231 (51%)
Ptprj	XP_006499054.1	fn3	162..222	CDD:365830	18/74 (24%)
		fn3	383..460	CDD:365830	19/84 (23%)
		FN3	469..553	CDD:238020	20/95 (21%)
		FN3	555..622	CDD:214495	18/75 (24%)
		FN3	642..721	CDD:238020	22/78 (28%)
		PTP_tm	831..1014	CDD:376280	42/202 (21%)
		R-PTPc-J	1083..1311	CDD:350463	116/230 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1616
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.910