DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprg

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_033007.2	Gene:	Ptprg / 19270	MGIID:	97814	Length:	1442	Species:	Mus musculus

Alignment Length:	1209	Identity:	285/1209 - (23%)
Similarity:	450/1209 - (37%)	Gaps:	407/1209 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 IVYHELETFNGDTSTLTTDRTRFTLESLLP---GRNY----SLSVQAVSKKMESNETSIFVVTRP 496
            :|:||.|||          ...|.|..|||   |..|    ||:....|:.:|      ::|.|.
Mouse   224 VVHHEKETF----------LDPFILRDLLPASLGSYYRYTGSLTTPPCSEIVE------WIVFRR 272

  Fly   497 SSPI----IEDLKSIRMGLNISWKSDVNSKQEQY--EVLYSRNGTSDLRTQKTKESRLVIKN-LQ 554
            ..||    :|...||           ..::|:.:  .|.|.||   :.|.|:....|:|.|: ::
Mouse   273 PVPISYHQLEAFYSI-----------FTTEQQDHVKSVEYLRN---NFRPQQALNDRVVSKSAVR 323

  Fly   555 PGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYR 619
            ....::|..| :.:.|.:|.    ..|..:||.:|.::.:...::.|.||.||
Mouse   324 DAWNHDLADF-LDNPLGTEA----SKVCSSPPIHMKVQPLNQTALQVSWSQPE------------ 371

  Fly   620 TDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVD 684
                                                              |:...|:.|.:
Mouse   372 --------------------------------------------------TIYHPPIMNYM---- 382

  Fly   685 SRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDI 749
               |:..|.|.|...|....|                     |....::..|..:.|...|.|.:
Mouse   383 ---ISYSWTKNEDEKEKTFTK---------------------DSDKDLKATISHVSPDSLYLFRV 423

  Fly   750 QTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAE 814
            |..   ..:.:.|.:.:|| |.|     ||..:..:...|..:..||...:|..|:...|.|.
Mouse   424 QAV---CRNDMRSDFSQTM-LFQ-----ANTTRIFQGTRIVKTGVPTASPASSADMAPISSGS-- 477

  Fly   815 IRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTE 879
                                        :.||.||                         |..:.
Mouse   478 ----------------------------STWTSSG-------------------------IPFSF 489

  Fly   880 ISLRWDL-PKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTV-VVRSGTESSVLR 942
            :|:...: |....:...:|.:....|||........|:        ::..|| ..|..|.|:..:
Mouse   490 VSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGIS--------SFPSTVWPTRLPTASAASK 546

  Fly   943 SSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGM 1007
            .:.....:.|...|.||       .||.        |.|:.::.|               |:.|.
Mouse   547 QAGRTVLATTEALASPG-------PDVD--------SAPTKDSEG---------------TEEGE 581

  Fly  1008 QDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQ-------------TMPILAPPRPA 1059
            ::.:||...|                         |||:.:             |.......|.|
Mouse   582 KEEKSESEDG-------------------------EREHEEEEKDSEKKEKSEATHTAAESDRTA 621

  Fly  1060 TQVVPTEVYRSSS-----TIQIRFRKNY---FSDQNGQVRMYTIIVAED-DAKNASGLEMPSWLD 1115
            ....|:..:|:::     ||..| |:::   .:||.|.       ||.| |....:..::|....
Mouse   622 PAPTPSSPHRTAAEGGHQTIPGR-RQDHSAPATDQPGH-------VAPDLDPLVDTATQVPPTAT 678

  Fly  1116 VQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKF 1180
            .:.||      ..||..| |..|.:                   |:..|             |:|
Mouse   679 EEHYS------GSDPRRP-EMPSKK-------------------PMSRG-------------DRF 704

  Fly  1181 TDTAYSFPIQTDQDNTSLIVA--------ITVPLTII-------LVLLVTLLFYKRRRNNCR--- 1227
            ::.:....:...:.|||.:::        ..:||.::       ||||:.:|.|.|..|..:
Mouse   705 SEDSKFITVNPAEKNTSGMLSRPSPGRMEWIIPLIVVSALTFVCLVLLIAVLVYWRGCNKIKSKG 769

  Fly  1228 -------------KTTKDSRA--------NDNMSLPDSVIEQNRPIL----------IKNFAEHY 1261
                         :..|.||.        .::.|.|..|..::.||:          :|.|.:|.
Mouse   770 FPRRSREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESVPIIPIPDDMEAIPVKQFGKHI 834

  Fly  1262 RLMSADSDFRFSEEFEELKHVGRDQPCT--FADLPCNRPKNRFTNILPYDHSRFKLQPV--DDDE 1322
            ..:.::|...|||:|||::....|...|  .::.|.|:.|||:.|||.|||||.||:|:  .|.:
Mouse   835 GELYSNSQHGFSEDFEEVQRCTADMNITAEHSNHPDNKHKNRYINILAYDHSRVKLRPLPGKDSK 899

  Fly  1323 GSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPN 1387
            .|||||||||.|:|..:.:|.|||||.||.:|||||.||.|:..|:|:|...||||.|||||||.
Mouse   900 HSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNLVEKGRRKCDQYWPT 964

  Fly  1388 DTVPVFYGDIKVQILNDSHYADWVMTEFML--------------CRGSEQRILRHFHFTTWPDFG 1438
            :.... ||:|.|.:.:...:|.:.:....:              .|.:|:.::: :|:|.|||.|
Mouse   965 ENTEE-YGNIIVTLKSTKVHACYTVRRLSVRNTKVKKGQKGNPKGRQNERTVIQ-YHYTQWPDMG 1027

  Fly  1439 VPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAM 1503
            ||.....::.|||........:..|::|||||||||:||:|.:|.:||||.....|::.|.:..:
Mouse  1028 VPEYALPVLTFVRRSSAARMPDMGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHI 1092

  Fly  1504 RKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMH 1542
            |.:|.::||||:|||.||..||..:.|||..|. :.::|
Mouse  1093 RTQRNYLVQTEEQYIFIHDALLEAILGKETEVS-SSQLH 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020	17/61 (28%)
		FN3	511..574	CDD:238020	13/65 (20%)
		FN3	583..671	CDD:238020	8/87 (9%)
		fn3	683..753	CDD:278470	12/69 (17%)
		fn3	787..850	CDD:278470	10/62 (16%)
		fn3	866..935	CDD:278470	11/70 (16%)
		fn3	961..1043	CDD:278470	10/81 (12%)
		PTPc	1272..1525	CDD:214550	115/270 (43%)
		PTPc	1298..1525	CDD:238006	105/242 (43%)
Ptprg	NP_033007.2	PLN02179	17..272	CDD:177835	18/63 (29%)
		alpha_CARP_receptor_like	67..319	CDD:239396	33/124 (27%)
		FN3	348..438	CDD:238020	24/182 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..480		5/48 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..726		47/270 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	769..788		1/18 (6%)
		PTPc	844..1115	CDD:214550	116/272 (43%)
		PTPc	873..1115	CDD:238006	106/243 (44%)
		Substrate binding. /evidence=ECO:0000250	1057..1063		5/5 (100%)
		PTPc	1147..1405	CDD:214550
		PTPc	1174..1405	CDD:238006
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1412..1442
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910