DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprf

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_006502927.1	Gene:	Ptprf / 19268	MGIID:	102695	Length:	1924	Species:	Mus musculus

Alignment Length:	1697	Identity:	400/1697 - (23%)
Similarity:	628/1697 - (37%)	Gaps:	515/1697 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 SPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTN--FTHHDWLTWTVTITTAPDPPSN 128
            :|.|..|.     :|:|:         :||...|.......  ..:..|:.....:|...:.|
Mouse   237 APRFSIPP-----SSQEV---------MPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMP-- 285

  Fly   129 LSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQHSVKELTPGATYQ 193
                  .|:|.:.|.:.....:||...|..||:.||             |.|.:||.|
Mouse   286 ------VGRNVLELSNVMRSANYTCVAISSLGMIEA-------------TAQVTVKAL------- 324

  Fly   194 VQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDA 258
                                   |..|...:|.....|::.:.|                   |:
Mouse   325 -----------------------PKPPIDLVVTETTATSVTLTW-------------------DS 347

  Fly   259 NDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTV----PLRPLNVT 319
            .::        ||     .:|.|:                        |||..    |.:.:
Mouse   348 GNT--------EP-----VSFYGI------------------------QYRAAGTDGPFQEV--- 372

  Fly   320 FDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVI 384
               |.:.|..:.:     .|:|.|.:|...|.........|.|..                  |.
Mouse   373 ---DGVASTRYSI-----GGLSPFSEYAFRVLAVNSIGRGPPSEA------------------VR 411

  Fly   385 VKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWE--ADPASTQDEYRIVY------ 441
            .:|.....:|.|       |.:..|.|      ..:||::.||  .:|......||:.|
Mouse   412 ARTGEQAPSSPP-------RRVQARML------SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRR 463

  Fly   442 -----HELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPII 501
                 |:   .|.|...||      |:.|||||..|||.|.|.:.          |...|.||.|
Mouse   464 PLSAWHK---HNTDAGLLT------TVGSLLPGITYSLRVLAFTA----------VGDGPPSPTI 509

  Fly   502 EDLKSIRMG-----------------LNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTK----- 544
            : :|: :.|                 :.:||......:..:||::|   ..::...|:.|
Mouse   510 Q-VKT-QQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVY---WAAEDEGQQHKVTFDP 569

  Fly   545 ESRLVIKNLQPGAGYELKVFAVSHDL--------------RSEPHAYFQAVYPNPPRNMTIETVR 595
            .|...:::|:|...|..::.|.| ||              :|.|.|        ||:.:|..:..
Mouse   570 TSSYTLEDLKPDTLYHFQLAARS-DLGVGVFTPTVEARTAQSTPSA--------PPQKVTCVSTG 625

  Fly   596 SNSVLVHWSPP----ESGEFTEYSIRYR-TDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTV 655
            |.:|.|.|.||    .:|..|:||:.|. .|.|.:...:....|.|....|:...||:|
Mouse   626 STTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWT------ 684

  Fly   656 SFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNV 720
                |..|....:|.|.|.|.|:.:.:....::                   ||..|.:|:
Mouse   685 ----EYRVWVRAHTDVGPGPESSPVLVRTDEDV-------------------PSGPPRKVE---- 722

  Fly   721 SENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLY-------PRTMPLIQSDVVVA 778
                 .:.|::..|       .|.:|..:....:|.:.|....|       ||..|:|| ||::|
Mouse   723 -----VEPLNSTAV-------HVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQ-DVMLA 774

  Fly   779 NG-----EKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGR 838
            ..     |.||...||:   ..||:::....:..::......|.|.|:       ||.||.||||
Mouse   775 EAQWRPEESEDYETTIS---GLTPETTYSITVAAYTTKGDGARSKPKV-------VTTTGAVPGR 829

  Fly   839 ---LYNITV-------W----TVSGGVASLPIQ--RQDRLYPEPI-----------TQLH----- 871
               :.:.|.       |    .:.|.:....:|  |.|...|..|           |.||
Mouse   830 PTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATY 894

  Fly   872 -----------------------------------ATNITDTEISLRWDLP-----KGEYNDFDI 896
                                               .|.:|.:...|.||.|     .|...::.:
Mouse   895 VFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITNYTV 959

  Fly   897 AYLTADNLL-AQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGR 960
            .|...::.| .||:|....:|:..|:|  :.|:.:.||:.|.    :.:.|||.|..:......:
Mouse   960 VYRDINSQLELQNVTNDTHLTLLGLKP--DTTYDIKVRAHTS----KGAGPLSPSIQSRTMPVEQ 1018

  Fly   961 V--ERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFG-----V 1018
            |  :.|.......:.:...|.:|.|..:.|  .|.|.|..            :|.|..|     :
Mouse  1019 VFAKNFRVAAAMKTSVLLSWEVPDSYKSAV--PFKILYNG------------QSVEVDGHSMRKL 1069

  Fly  1019 IKNLKPGETYVFKIQAKTAIGFGPEREYR-QTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNY 1082
            |.:|:|...|.|.:..:.:...|.:.... :|.|.|.|.:|    :|...:....    ||..:.
Mouse  1070 IADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKP----LPASAFIEDG----RFSLSM 1126

  Fly  1083 FSDQN-GQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAID----------------- 1129
            ...|: ..||.:.|:|...| :....|..|.|...:...:....:||:
Mouse  1127 PQVQDPSLVRWFYIVVVPID-RVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLK 1190

  Fly  1130 PYYPFENRSVED-FTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAF----TGADKFTDTAYS--- 1186
            ||...:...:.| ||:|.:....   |:.|.||....:|:..|.|.    ....::..:.||
Mouse  1191 PYVAAQVDVLPDTFTLGDKKSYR---GFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEI 1252

  Fly  1187 ----FPIQTDQDNTSLIVAITVPLTIILVLLV-TLLFYKRRRNNCRKTTKDSRANDNMSLPDSV- 1245
                .|.|..::...|.|...|...|:::|:| .:|.:||:|.:    :..|:...::.|.||:
Mouse  1253 VVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTH----SPSSKDEQSIGLKDSLL 1313

  Fly  1246 ------IEQNR-----------------------PILIKNFAEHYRLMSADSDFRFSEEFEELKH 1281
                  :|..|                       ||.|.:.|::...:.|:...:||:|:|.: .
Mouse  1314 AHSSDPVEMRRLNYQTPGSSAPSCPNISSMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-D 1377

  Fly  1282 VGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQG 1346
            .|:......::...|:||||:.|::.|||||..|..:|...|||||||||:.|:.....:|.|||
Mouse  1378 PGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQG 1442

  Fly  1347 PLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP---NDTVPVFYGDIKVQILNDSHYA 1408
            ||..|..|||||.||..:..:||:||..||.|.|||||||   .:|    ||.|:|.:::....|
Mouse  1443 PLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTET----YGLIQVTLVDTVELA 1503

  Fly  1409 DWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAG 1471
            .:.|..|.|.:  .||:|.||.|.|..|||.|||..|..::.|:|..:.....:..|:|||||||
Mouse  1504 TYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAG 1568

  Fly  1472 VGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEGKENIV 1535
            |||:|.||.:|.:|:::.....|||:|.|..||.:|.:|||||.||:.||:.|| |.:.|...::
Mouse  1569 VGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVL 1633

  Fly  1536 GPAREMH 1542
              ||.::
Mouse  1634 --ARNLY 1638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	16/80 (20%)
		fn3	220..304	CDD:278470	9/83 (11%)
		fn3	315..391	CDD:278470	11/75 (15%)
		FN3	405..494	CDD:238020	27/101 (27%)
		FN3	511..574	CDD:238020	16/81 (20%)
		FN3	583..671	CDD:238020	25/92 (27%)
		fn3	683..753	CDD:278470	8/69 (12%)
		fn3	787..850	CDD:278470	17/76 (22%)
		fn3	866..935	CDD:278470	22/125 (18%)
		fn3	961..1043	CDD:278470	18/88 (20%)
		PTPc	1272..1525	CDD:214550	114/257 (44%)
		PTPc	1298..1525	CDD:238006	108/231 (47%)
Ptprf	XP_006502927.1	I-set	33..124	CDD:369462
		Ig2_RPTP_IIa_LAR_like	152..232	CDD:319301
		Ig3_RPTP_IIa_LAR_like	252..320	CDD:143216	17/88 (19%)
		FN3	325..414	CDD:238020	24/173 (14%)
		FN3	421..513	CDD:238020	34/124 (27%)
		FN3	518..607	CDD:238020	15/92 (16%)
		FN3	615..709	CDD:238020	29/103 (28%)
		FN3	716..822	CDD:238020	28/132 (21%)
		FN3	827..916	CDD:238020	14/88 (16%)
		FN3	925..1013	CDD:238020	23/93 (25%)
		FN3	1022..>1081	CDD:238020	15/72 (21%)
		PTP_DSP_cys	1352..1627	CDD:391942	119/279 (43%)
		R-PTP-F-2	1629..1919	CDD:350477	2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940