DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprc

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001104786.2	Gene:	Ptprc / 19264	MGIID:	97810	Length:	1293	Species:	Mus musculus

Alignment Length:	1475	Identity:	324/1475 - (21%)
Similarity:	527/1475 - (35%)	Gaps:	383/1475 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 GYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWS---PPESGEFTEYSIRYR 619
            |..||:.|....| .:...:.....|.|...:   :...|::|:..|   |..:.|.|..||..|
Mouse     4 GLWLKLLAFGFAL-LDTEVFVTGQTPTPSDEL---STTENALLLPQSDPLPARTTESTPPSISER 64

  Fly   620 TDSEQQWVRLPSVRST-------EADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVS 677
            .:...:....|.|.||       :.|....:.|     ..:|.:|.     .|..|.|:.|.|..
Mouse    65 GNGSSETTYHPGVLSTLLPHLSPQPDSQTPSAG-----GADTQTFS-----SQADNPTLTPAPGG 119

  Fly   678 NIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPG 742
            .    .|...:..|...| |.:        |:|....|.|.:::.|.||              ..
Mouse   120 G----TDPPGVPGERTVP-GTI--------PADTAFPVDTPSLARNSSA--------------AS 157

  Fly   743 VQYKFDIQTTSYGILSGITSLYPRTMPLIQSD---VVVANGEKED---ERDTITLSYTPTPQSSS 801
            ..:..::.||.....:.:|:|.|.|:.|..:|   ..:|...|:.   ....||::|| ...|:.
Mouse   158 PTHTSNVSTTDISSGASLTTLTPSTLGLASTDPPSTTIATTTKQTCAAMFGNITVNYT-YESSNQ 221

  Fly   802 KF-----DIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDR 861
            .|     |:.....|:   .|.|.:.|:.:.        ..::.||:|    ...:..|....|
Mouse   222 TFKADLKDVQNAKCGN---EDCENVLNNLEE--------CSQIKNISV----SNDSCAPATTID- 270

  Fly   862 LYPEPIT---QLH---ATNITDTEISLRWDLPKGEYNDFDIAYLTADNL--------------LA 906
            ||..|.|   .||   .....:|.|.|.|     :..:.|.....:||:              :.
Mouse   271 LYVPPGTDKFSLHDCTPKEKANTSICLEW-----KTKNLDFRKCNSDNISYVLHCEPENNTKCIR 330

  Fly   907 QNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQP 971
            :|........:.:||...|||..        :.:|.....|..:....:...|..|...|:...|
Mouse   331 RNTFIPERCQLDNLRAQTNYTCV--------AEILYRGVKLVKNVINVQTDLGIPETPKPSCGDP 387

  Fly   972 S--EINFEWSLPSSEANGVIRQ--FSIAYTN--------INNLTDAGMQDFESEEAFGVIKNLKP 1024
            :  :....|..|.|:.....:.  :.:.|.|        .||:|     .||       :::|||
Mouse   388 AARKTLVSWPEPVSKPESASKPHGYVLCYKNNSEKCKSLPNNVT-----SFE-------VESLKP 440

  Fly  1025 GETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQ 1089
            .:.|...:.|..                                  :..||          :||.
Mouse   441 YKYYEVSLLAYV----------------------------------NGKIQ----------RNGT 461

  Fly  1090 VRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWL--PYQAIDP--YYPFENRSVEDFT--IGTEN 1148
            ..........|.....:|::.....| .|.:|..  ||:...|  :|....||...|.  ....|
Mouse   462 AEKCNFHTKADRPDKVNGMKTSRPTD-NSINVTCGPPYETNGPKTFYILVVRSGGSFVTKYNKTN 525

  Fly  1149 C----DNHKIGYCNGPLKSGTTYRVKVR----AFTGADKFTDTAYSFPIQTDQDNTSLIVAITVP 1205
            |    ||         |...|.|...|.    .:.|.....:.:.:|       |...::...|.
Mouse   526 CQFYVDN---------LYYSTDYEFLVSFHNGVYEGDSVIRNESTNF-------NAKALIIFLVF 574

  Fly  1206 LTIILVLLVTLLFY------KRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLM 1264
            |.|:..:.:.::.|      |:|.:|..:..:....:|...|.|  :|   ||......|.|:..
Mouse   575 LIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDDEKQLMD--VE---PIHSDILLETYKRK 634

  Fly  1265 SADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINA 1329
            .||....|..||:.:..|....|...|..|.|:.|||:.:|||||::|.:|..::.|.||.||||
Mouse   635 IADEGRLFLAEFQSIPRVFSKFPIKDARKPHNQNKNRYVDILPYDYNRVELSEINGDAGSTYINA 699

  Fly  1330 NYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPN-DTVPVF 1393
            :|:.|...||::|..|||...|.||||||.||..:..|||:|||.|..|.||.:|||: :.....
Mouse   700 SYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRA 764

  Fly  1394 YGDIKVQILNDSHYADWVMTEFMLCRGSEQ---RILRHFHFTTWPDFGVPNPPQTLV---RFVRA 1452
            :.||.|.|.:.....|:::.:..:....|:   |.:.|..||:|||.|||..|..|:   |.|.|
Mouse   765 FKDIVVTINDHKRCPDYIIQKLNVAHKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA 829

  Fly  1453 FRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQY 1517
            |.:....   ||||||||||||:||:|.:|.:|:.:.....||::|.|..:|::|..|||.|.||
Mouse   830 FSNFFSG---PIVVHCSAGVGRTGTYIGIDAMLEGLEAEGKVDVYGYVVKLRRQRCLMVQVEAQY 891

  Fly  1518 ICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVATI-EGHLSHHDLQQAEAEAI 1581
            |.|||.|                           |:.::.|:....: |.|...|::::.:..:
Mouse   892 ILIHQAL---------------------------VEYNQFGETEVNLSELHSCLHNMKKRDPPS- 928

  Fly  1582 DDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSSFGGGGGGHTNVDAPDRXHSVVNQSDNNNSVV 1646
                      |..||.:.:    ..:|...|.                 |...:.||.:|...
Mouse   929 ----------DPSPLEAEY----QRLPSYRSW-----------------RTQHIGNQEENKKK-- 960

  Fly  1647 IVLVDNKPSSMICKDSKGGNI-DVLESQQQQQQQQQQQPNQGGHNITTISAINGYNTLQHRRKSQ 1710
                 |:.|:::..|.....: ..||..::.:.:..:..:....:..|...||....:.:.:...
Mouse   961 -----NRNSNVVPYDFNRVPLKHELEMSKESEPESDESSDDDSDSEETSKYINASFVMSYWKPEM 1020

  Fly  1711 LITFSSSSCDIKNSLSH-----------------EYINGSNGSAA----NGPPSSGSGSGSGPGS 1754
            :|   ::...:|.::..                 |.:||.....|    .|..:.|........:
Mouse  1021 MI---AAQGPLKETIGDFWQMIFQRKVKVIVMLTELVNGDQEVCAQYWGEGKQTYGDMEVEMKDT 1082

  Fly  1755 NRASRANVRLSFAEEDVMILPQNHSQQSNHQDDEVFTRRRSLLEVEIGVEVGEDGELAPHE---M 1816
            ||||...:|         .....||::.         ..|::.:.:.....||:....|.:   |
Mouse  1083 NRASAYTLR---------TFELRHSKRK---------EPRTVYQYQCTTWKGEELPAEPKDLVSM 1129

  Fly  1817 EEDLEEE-----DEDEELYMHDEFETHIDTKSNNANDDSGGGSYEDSHALHSSLGGSNRNSLEKD 1876
            .:||:::     .|..:.:.|.....|    ..:.:..:|         |..:|    .|.||..
Mouse  1130 IQDLKQKLPKASPEGMKYHKHASILVH----CRDGSQQTG---------LFCAL----FNLLESA 1177

  Fly  1877 DDDIEVDVIST---------DVSC-YDQ------LLGSSCNTRNG 1905
            :.:..|||...         .|.| |:|      ::.|....:||
Mouse  1178 ETEDVVDVFQVVKSLRKARPGVVCSYEQYQFLYDIIASIYPAQNG 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020	5/15 (33%)
		FN3	583..671	CDD:238020	21/97 (22%)
		fn3	683..753	CDD:278470	12/69 (17%)
		fn3	787..850	CDD:278470	14/67 (21%)
		fn3	866..935	CDD:278470	17/88 (19%)
		fn3	961..1043	CDD:278470	18/93 (19%)
		PTPc	1272..1525	CDD:214550	110/259 (42%)
		PTPc	1298..1525	CDD:238006	102/233 (44%)
Ptprc	NP_001104786.2	PTP_N	7..31	CDD:372119	5/24 (21%)
		Herpes_BLLF1	<27..>191	CDD:282904	43/203 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..174		33/167 (20%)
		CD45	212..265	CDD:372194	12/68 (18%)
		FN3	393..451	CDD:238020	14/69 (20%)
		FN3	474..553	CDD:238020	19/88 (22%)
		R-PTPc-C-1	696..896	CDD:350405	87/202 (43%)
		Substrate binding. /evidence=ECO:0000250	842..848		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	980..1003		2/22 (9%)
		R-PTP-C-2	1006..1211	CDD:350406	40/242 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1240..1293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910