DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprb

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_036011586.1	Gene:	Ptprb / 19263	MGIID:	97809	Length:	2361	Species:	Mus musculus

Alignment Length:	1653	Identity:	503/1653 - (30%)
Similarity:	761/1653 - (46%)	Gaps:	262/1653 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 EIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVTIT---------------TAPDPPSNLSVQVRS 135
            |..|:..:||..|.                 .|:|               |.|...::|.|..:.
Mouse   807 EFTFTDLMPGRNYK-----------------ATVTSMSGDLKQSSSIKGRTVPAQVTDLHVNNQG 854

  Fly   136 GKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIY 200
            ..:::........|....:  :||.:.|.....|.:  |:.:|.::|.:.|.||:.|.|...|:.
Mouse   855 MTSSLFTNWTKALGDVEFY--QVLLIHENVVVKNES--VSSDTSRYSFRALKPGSLYSVVVTTVS 915

  Fly   201 DGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYV 265
            .|..|....:...|...:..|..:........|.|.|.|  ..|...||.||:......|..|.:
Mouse   916 GGISSRQVVAEGRTVPSSVSGVTVNNSGRNDYLSVSWLP--APGEVDHYVVSLSHEGKVDQFLII 978

  Fly   266 EKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSF 330
            .|     ..::.:|..|.|||.||::|.|.|.:..|...|.: ||||.:...::      .|||.
Mouse   979 AK-----SVSECSFSSLTPGRLYNVTVTTKSGNYASHSFTEE-RTVPDKVQGIS------VSNSA 1031

  Fly   331 R-----VLWEAPKGISEFDKYQVSVATTRRQS-----TVPRSNEPVAFFDFRDIAEPGKTFNVIV 385
            |     |.|....|  :||.|:|::  ..|:|     |:|:|.....|.:.    .||:.::|.|
Mouse  1032 RSDYLKVSWVHATG--DFDHYEVTI--KNRESFIQTKTIPKSENECEFIEL----VPGRLYSVTV 1088

  Fly   386 KTVSGKV-TSWPATGDVTLRPLPVRNLRSINDDKTNTMIITW-EADPASTQDEYRIVYHELETFN 448
            .|.||:. .|...||...  |.||::|..:| ..|..:.:|| .|:....|.|.::::::::.|
Mouse  1089 STKSGQYEASEQGTGRTI--PEPVKDLTLLN-RSTEDLHVTWSRANGDVDQYEVQLLFNDMKVF- 1149

  Fly   449 GDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFV--VTRPSSPIIEDLKSIRMGL 511
             ....|....|.:...:|.|||:|.:.|..:|..::.   |.|:  :|.||:     :|:|.:..
Mouse  1150 -PHIHLVNTATEYKFTALTPGRHYKILVLTISGDVQQ---SAFIEGLTVPST-----VKNIHISA 1205

  Fly   512 N-------ISWK---SDVNSKQEQYEV-LYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFA 565
            |       ::|.   .||:|    |.| .:.::...|.:|.....|......|:.||.|.:.:.:
Mouse  1206 NGATDRLMVTWSPGGGDVDS----YVVSAFRQDEKVDSQTIPKHASEHTFHRLEAGAKYRIAIVS 1266

  Fly   566 VSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTD--------S 622
            ||..||::..|..|.|..:....:......|||:.|.|. ...|....|.|....:        |
Mouse  1267 VSGSLRNQIDALGQTVPASVQGVVAANAYSSNSLTVSWQ-KALGVAERYDILLLNENGLLLSNVS 1330

  Fly   623 EQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNI-IQLVDSR 686
            |....|       :....|:|.|:||.:|:.|||.|:.|...|....|||. .|:|: |....||
Mouse  1331 EPATAR-------QHKFEDLTPGKKYKMQILTVSGGLFSKESQAEGRTVPA-AVTNLRITENSSR 1387

  Fly   687 NITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQT 751
            .::..|...||.:..|.:..:   ||.|    .:.|....|.| ........|:.|..||..|.|
Mouse  1388 YLSFGWTASEGELSWYNIFLY---NPDR----TLQERAQVDPL-VQSFSFQNLLQGRMYKMVIVT 1444

  Fly   752 TSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIR 816
            .| |.||..:.::.||:|...:.:   .|...:..|::..|::|   :|..||.|...|.:....
Mouse  1445 HS-GELSNESFIFGRTVPAAVNHL---KGSHRNTTDSLWFSWSP---ASGDFDFYELILYNPNGT 1502

  Fly   817 DKEKLANDTDRKVT---FTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDT 878
            .||   |..::.||   |.||||||.|.:.|.|.||.::: .:..:.|..|.|.:.|...::.:|
Mouse  1503 KKE---NWKEKDVTEWRFQGLVPGRKYTLYVVTHSGDLSN-KVTGEGRTAPSPPSLLSFADVANT 1563

  Fly   879 EISLRWDLPKG--EYNDFDIAYLTADNLLAQNMTTRNEI---TISDLRPHRNYTFTVVVRSGTES 938
            .:::.|..|..  :||||::.:...|.|...|..:..:.   .:..|.|.|:|.|:|...||  .
Mouse  1564 SLAITWKGPPDWTDYNDFELQWFPGDALTIFNPYSSRKSEGRIVYGLHPGRSYQFSVKTVSG--D 1626

  Fly   939 SVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLT 1003
            |....|.|:|.|..|.   |.:::..|......:.|...|..|.|:.:|    :||....::...
Mouse  1627 SWKTYSKPISGSVRTK---PDKIQNLHCRPQNSTAIACSWIPPDSDFDG----YSIECRKMDTQE 1684

  Fly  1004 DAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPIL-APPRPATQVVPTE- 1066
            ....:..|.|::...|..|.|.:.|:..|:.::| |...|.....|:.:: .||:|...:...|
Mouse  1685 IEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA-GMTSEVVEDSTITMIDRPPQPPPHIRVNEK 1748

  Fly  1067 -VYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAE----DDAKNASGLEMPSWLDVQSYSVWLPYQ 1126
             |..|.|:|......::|||.||.|:.:.::|.|    |:.|......:||:|:.:..:....||
Mouse  1749 DVLISKSSINFTVNCSWFSDTNGAVKYFAVVVREADSMDELKPEQQHPLPSYLEYRHNASIRVYQ 1813

  Fly  1127 AIDPYYPFE-----NRSVEDFTI--GTE------NCDNHKIGYCNGPLKSGTTYRVKVRAFT--- 1175
            .  .|:..:     :.|.:.|.|  |.|      .||..:..:|:||||..|.||:.:||||
Mouse  1814 T--NYFASKCAESPDSSSKSFNIKLGAEMDSLGGKCDPSQQKFCDGPLKPHTAYRISIRAFTQLF 1876

  Fly  1176 --GADKFT-----DTAYSFPIQTDQDNT-SLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKD 1232
              ...:||     ||.:|.||.|:.:.. .:|..::..|.:|.:|:..:.|:     .||:....
Mouse  1877 DEDLKEFTKPLYSDTFFSMPITTESEPLFGVIEGVSAGLFLIGMLVALVAFF-----ICRQKASH 1936

  Fly  1233 SRANDNMSL------PDSV-----IEQNR----PILIKNFAEHYRLMSADSDFRFSEEFEELKHV 1282
            ||...:..|      |.||     .:.||    ||.|..|..|:..:.|||::..|:|:|:||.|
Mouse  1937 SRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEDLKDV 2001

  Fly  1283 GRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGP 1347
            ||.|.|..|.||.||.|||:.||||||.||.||..||||..||||||:|:||:|..||:|.||||
Mouse  2002 GRSQSCDIALLPENRGKNRYNNILPYDASRVKLCNVDDDPCSDYINASYIPGNNFRREYIATQGP 2066

  Fly  1348 LHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVM 1412
            |..|:||||:|.||.|...|||:|:|.||||.|||.|||.|..|::|||:.:|::::|...:|.:
Mouse  2067 LPGTKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDPLYYGDLILQMVSESVLPEWTI 2131

  Fly  1413 TEFMLCRGSEQ----RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRI----GAEQRPIVVHCS 1469
            .||.:| ..||    |::||||:|.|||.|||...|:|::|||..||.|    ||  .|.|||||
Mouse  2132 REFKIC-SEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGA--GPTVVHCS 2193

  Fly  1470 AGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK--- 1531
            |||||:|||:.|||||||:::.|.|||:|.|:.:|..||.|||||.||:.:|||:..||..|
Mouse  2194 AGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAKKLR 2258

  Fly  1532 ---ENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLSHH----------------DLQQAE 1577
               ||.:.|..|..:.|.:....|.      |..||...|..|                |::.:.
Mouse  2259 NEQENPLFPIYENVNPEYHRALHVA------VTPTITFPLPLHNCALPIVLNHNMQSTRDIKNSP 2317

  Fly  1578 AEAID---------------DENAAILH 1590
            .:.:|               ::|..:||
Mouse  2318 EDPLDKSVSLCDFKKKQKQKNKNKTLLH 2345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	17/80 (21%)
		fn3	220..304	CDD:278470	24/83 (29%)
		fn3	315..391	CDD:278470	23/85 (27%)
		FN3	405..494	CDD:238020	23/91 (25%)
		FN3	511..574	CDD:238020	18/73 (25%)
		FN3	583..671	CDD:238020	23/95 (24%)
		fn3	683..753	CDD:278470	18/69 (26%)
		fn3	787..850	CDD:278470	24/65 (37%)
		fn3	866..935	CDD:278470	18/73 (25%)
		fn3	961..1043	CDD:278470	17/81 (21%)
		PTPc	1272..1525	CDD:214550	149/260 (57%)
		PTPc	1298..1525	CDD:238006	134/234 (57%)
Ptprb	XP_036011586.1	Ricin_B_lectin	<22..93	CDD:395527
		Herpes_BLLF1	<158..>352	CDD:282904
		FN3	398..483	CDD:238020
		fn3	492..560	CDD:394996
		fn3	579..658	CDD:394996
		fn3	681..742	CDD:394996
		fn3	757..835	CDD:394996	7/44 (16%)
		fn3	844..917	CDD:394996	16/76 (21%)
		fn3	932..1010	CDD:394996	23/84 (27%)
		fn3	1020..1096	CDD:394996	24/89 (27%)
		fn3	1109..1182	CDD:394996	20/75 (27%)
		fn3	1196..1269	CDD:394996	18/81 (22%)
		fn3	1285..1365	CDD:394996	22/87 (25%)
		fn3	1375..1448	CDD:394996	22/81 (27%)
		fn3	1473..1536	CDD:394996	24/68 (35%)
		fn3	1550..1632	CDD:394996	21/83 (25%)
		fn3	1644..1723	CDD:394996	17/83 (20%)
		PTP_tm	1761..1931	CDD:408631	48/176 (27%)
		R-PTPc-B	2019..2246	CDD:350465	130/229 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1616
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2125
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1040
Isobase	1	0.950	-	0	Normalized mean entropy	S5167
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm42906
orthoMCL	1	0.900	-	-		OOG6_106915
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X4185
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.710