DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptpn20

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_006518791.1	Gene:	Ptpn20 / 19256	MGIID:	1196295	Length:	463	Species:	Mus musculus

Alignment Length:	387	Identity:	112/387 - (28%)
Similarity:	178/387 - (45%)	Gaps:	63/387 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1177 ADKFTDTAYSFPIQTDQDNT--------------SLIVAITVPLTIILVLLVTLLFYKRRRNNCR 1227
            :||: :..|..|:::|.|.|              |:......|...:..:|          :...
Mouse   100 SDKY-ELVYPEPLESDTDETVWDVSDRSLRNRWNSMDSETAGPSKTVSPVL----------SGSS 153

  Fly  1228 KTTKDSRANDNMSLPDSVIE-------QNRPILIKNFA-----EHYRLMSADSDFRFSEEFEELK 1280
            :.:||:..        ||.|       |.||::..:.|     :....:....:.....||.||:
Mouse   154 RLSKDTET--------SVSEKELTQLAQIRPLIFNSSARSAMRDCLNTLQKKEELDIIREFLELE 210

  Fly  1281 HVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANY--VPGHNSPREFIV 1343
            .:.........:...||.|||:.:|||||.:|..|     .:..|||||:|  :..|.....:|.
Mouse   211 QMTLPDDFNSGNTLQNRDKNRYRDILPYDSTRVPL-----GKNKDYINASYIRIVNHEEEYFYIA 270

  Fly  1344 TQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP---NDTVPVFYGDIKVQILNDS 1405
            |||||..|.:|||:|..|:|...|.|:||..|.|..||..|||   .:.:...:..:.::..:.:
Mouse   271 TQGPLPETIEDFWQMVLENNCNVIAMITREIECGVIKCYSYWPISLKEPLEFEHFSVFLETFHVT 335

  Fly  1406 HYADWVMTEFMLCRGS--EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFR-DRIGAEQRPIVVH 1467
            .|  :.:..|.:.:.|  :.:.::|..||.|||.|.|......:::||..| ..|..   |::||
Mouse   336 QY--FTVRVFQIVKKSTGKSQCVKHLQFTKWPDHGTPASADFFIKYVRYVRKSHITG---PLLVH 395

  Fly  1468 CSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE 1529
            |||||||:|.||.:|.:...|..:...||..||..|||:|..|:||::||...::.:|.||:
Mouse   396 CSAGVGRTGVFICVDVVFSAIEKNYSFDIMNIVTQMRKQRCGMIQTKEQYQFCYEIVLEVLQ 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	90/260 (35%)
		PTPc	1298..1525	CDD:238006	84/234 (36%)
Ptpn20	XP_006518791.1	PTP_DSP_cys	251..457	CDD:391942	75/210 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910