DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptpn2

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001120649.1	Gene:	Ptpn2 / 19255	MGIID:	97806	Length:	406	Species:	Mus musculus

Alignment Length:	355	Identity:	112/355 - (31%)
Similarity:	191/355 - (53%)	Gaps:	33/355 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1267 DSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANY 1331
            |:..|:...:.|:::...|.|...|..|.||.:||:.::.||||||.|||..:    :|||||:.
Mouse    13 DAQCRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQSTE----NDYINASL 73

  Fly  1332 VPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGD 1396
            |....:.|.:|:|||||.:|...||.|.|:..::|:|||.|..||...||.||||.|...:.:.:
Mouse    74 VDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRTVEKESVKCAQYWPTDDREMVFKE 138

  Fly  1397 --IKVQILND---SHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR 1456
              ..|::|::   |:|...::....:..| |.|.:.|||:|||||||||..|.:.:.|:...|:.
Mouse   139 TGFSVKLLSEDVKSYYTVHLLQLENINTG-ETRTISHFHYTTWPDFGVPESPASFLNFLFKVRES 202

  Fly  1457 --IGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYIC 1519
              :..:..|.|:|||||:||||||..:|..|..:...:.|::..::..|||.|:.::||..|
Mouse   203 GCLTPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGEDVNVKQLLLNMRKYRMGLIQTPDQ--- 264

  Fly  1520 IHQCLLAVLEGKE------NIVGPAREMHDNE-----GYEGQQVQLDE-NGDVVATIEGHLSHHD 1572
            :....:|::||.:      ||....:|:...:     .:...:|.::: ||..:.:.:..|:  .
Mouse   265 LRFSYMAIIEGAKYTKGDSNIQKRWKELSKEDLSPICDHSQNRVMVEKYNGKRIGSEDEKLT--G 327

  Fly  1573 LQQAEAEAIDDENAAIL----HDDQQPLTS 1598
            |.....:.:::.:.:||    .:|::..|:
Mouse   328 LPSKVQDTVEESSESILRKRIREDRKATTA 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	95/259 (37%)
		PTPc	1298..1525	CDD:238006	88/233 (38%)
Ptpn2	NP_001120649.1	PTPc	5..274	CDD:214550	98/268 (37%)
		PTPc	45..274	CDD:238006	89/236 (38%)
		Substrate binding. /evidence=ECO:0000250	216..222		4/5 (80%)
		Endoplasmic reticulum location. /evidence=ECO:0000250	341..406		4/17 (24%)
		Mediates interaction with STX17. /evidence=ECO:0000250	371..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910