DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptpn1

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_035331.3	Gene:	Ptpn1 / 19246	MGIID:	97805	Length:	432	Species:	Mus musculus

Alignment Length:	392	Identity:	130/392 - (33%)
Similarity:	197/392 - (50%)	Gaps:	44/392 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1255 KNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVD 1319
            |.|.|      .|....::..:::::|...|.||..|.||.|:.:||:.::.|:||||.||.
Mouse     5 KEFEE------IDKAGNWAAIYQDIRHEASDFPCKVAKLPKNKNRNRYRDVSPFDHSRIKLH--- 60

  Fly  1320 DDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQY 1384
             .|.:|||||:.:....:.|.:|:|||||.:|...||.|.||..||.:|||.|..|||..||.||
Mouse    61 -QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQY 124

  Fly  1385 WP-NDTVPVFYGD--IKVQILNDSHYADWVMTEFML--CRGSEQRILRHFHFTTWPDFGVPNPPQ 1444
            || .:...:.:.|  :|:.::::...:.:.:.:..|  ....|.|.:.|||:|||||||||..|.
Mouse   125 WPQQEEKEMVFDDTGLKLTLISEDVKSYYTVRQLELENLTTKETREILHFHYTTWPDFGVPESPA 189

  Fly  1445 TLVRFVRAFRD--RIGAEQRPIVVHCSAGVGRSGTFITLDR---ILQQINTSDYVDIFGIVYAMR 1504
            :.:.|:...|:  .:..|..|||||||||:||||||...|.   ::.:......|||..::..||
Mouse   190 SFLNFLFKVRESGSLSLEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMR 254

  Fly  1505 KERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVV-------- 1561
            :.|:.::||..|   :....|||:||.:.|:|.:..  .::..|..:..||...:.|
Mouse   255 RFRMGLIQTADQ---LRFSYLAVIEGAKFIMGDSSV--QDQWKELSREDLDLPPEHVPPPPRPPK 314

  Fly  1562 ATIEGH-------LSHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSSFGGG 1619
            .|:|.|       .|.|  |....|...||::  |..::....||.....:.|.|.|.:.....|
Mouse   315 RTLEPHNGKCKELFSSH--QWVSEETCGDEDS--LAREEGRAQSSAMHSVSSMSPDTEVRRRMVG 375

  Fly  1620 GG 1621
            ||
Mouse   376 GG 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	97/262 (37%)
		PTPc	1298..1525	CDD:238006	89/236 (38%)
Ptpn1	NP_035331.3	PTPc	3..276	CDD:214550	104/283 (37%)
		PTPc	43..276	CDD:238006	92/239 (38%)
		Substrate binding. /evidence=ECO:0000250	215..221		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..322		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..399		12/45 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910