DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptp-5.2

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_502779.1	Gene:	ptp-5.2 / 190372	WormBaseID:	WBGene00013304	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	76/382 - (19%)
Similarity:	142/382 - (37%)	Gaps:	68/382 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1190 QTDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTT---KDSRANDNMSLPDSVIEQNR- 1250
            ||.:|:..|.:|.:|..|:....:..||..:......::..   |.|:...|.:....|..::.
Worm    96 QTVEDDPPLPIATSVAGTVTTTGMPALLPAENATQPLKEVVNSGKKSKGAPNSATATPVSHKSTI 160

  Fly  1251 ---------PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNIL 1306
                     ..:.||:.:...|...      .:|||:|:.:..|..........|...|:..:..
Worm   161 TEGADKWVGEDVAKNWMDSIDLAEV------KKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFP 219

  Fly  1307 PYDHSRFKLQPVDDDEGSDYINANYVPGHNSP--REFIVTQGPLHSTRDDFWRMCWESNSRAIVM 1369
            ..|.:..|::       .||:|.:.|   ..|  |...:.|.|:..|.:.||:..::....:|.:
Worm   220 ALDSNLLKVE-------KDYVNISRV---EIPLGRNIYIGQVPVKDTEETFWKAVFDKRIVSIDV 274

  Fly  1370 LT-----RCFEKGREKCDQY---WPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRIL 1426
            :.     ..|.|..|....|   |.|:.        ||:.::|..:.   .:..:|..|....|:
Worm   275 IVGDEPIEFFPKKAEDYKNYGQMWINNR--------KVEYVSDDVFR---FSIEVLPHGCSNSII 328

  Fly  1427 RHFH-FTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPI--------VVHCSAGVGRSGTFITLD 1482
            .:.. .:.|....||      |:...|.::..|.....:        :::...|.||:|.|:.|.
Worm   329 CNVTVISNWKVDSVP------VKQAIAIKEAFGLNSYLLKAPADDNAMINSQHGAGRAGYFLALA 387

  Fly  1483 RILQQINTSDYVD-IFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPA 1538
            ..:..|:|..... |..||.::|.:|...|.:..||..::..||..:  |:.:..||
Worm   388 VAVHTIDTKVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFI--KKKVTKPA 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	55/272 (20%)
		PTPc	1298..1525	CDD:238006	49/246 (20%)
ptp-5.2	NP_502779.1	PTPc	185..432	CDD:214550	56/279 (20%)
ptp-5.2	NP_502779.1	PTPc_motif	336..432	CDD:214649	23/101 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910