DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Plcg1

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_067255.2	Gene:	Plcg1 / 18803	MGIID:	97615	Length:	1302	Species:	Mus musculus

Alignment Length:	1314	Identity:	220/1314 - (16%)
Similarity:	416/1314 - (31%)	Gaps:	444/1314 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 KTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQDEYR--IVY 441
            |||.|.::|   :..:|....|.....:.:|.::.|...||:.....::.|||...|:..  ::.
Mouse    49 KTFQVKLET---RQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVIL 110

  Fly   442 HELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKS 506
            :.:|               |.|:        :||:||.|:    :|.::::  :..:.::||...
Mouse   111 YGME---------------FRLK--------TLSLQATSE----DEVNMWI--KGLTWLMEDTLQ 146

  Fly   507 IRMGLNIS-WKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLV---IKNLQPGAGYE------L 561
            ....|.|. |     .:::.|.|            .:.:|.|:.   :||:.....|.      |
Mouse   147 AATPLQIERW-----LRKQFYSV------------DRNREDRISAKDLKNMLSQVNYRVPNMRFL 194

  Fly   562 KVFAVSHDLRSEPHAY------FQAVYPNPPRNMTIETVRSNSVLVHWSPPES----GEFTEYSI 616
            :......:.||....|      ::::..:..:.|.:..:.:|::.....|...    .||.::.:
Mouse   195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNALRTGERPEHCQVSLSEFQQFLL 259

  Fly   617 RYRTD------SEQQWVRLPSVRSTEADITDMTKGEKYTI--QVNTVSFGVESPVPQEVNTTVPP 673
            .|:.:      .:.|...|..:|....:|.     |.|..  ::.|..|..|:.|.......|.|
Mouse   260 EYQGELWAVDRLQVQEFMLSFLRDPLREIE-----EPYFFLDELVTFLFSKENSVWNSQLDAVCP 319

  Fly   674 NPVSNIIQ---LVDSRN--ITLEWPKPEGRVESYI-----------LKWW--PSDNP----GRVQ 716
            :.::|.:.   :..|.|  :|.:....|..:|:|.           |..|  |...|    |...
Mouse   320 DTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTL 384

  Fly   717 TKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGE 781
            |..:   |.:|.|.|::          ::.|            :.|.||..:.:
Mouse   385 TTKI---KFSDVLHTIK----------EHAF------------VASEYPVILSI----------- 413

  Fly   782 KEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGL-VPGRLYNITVW 845
             ||        :....|..:....:|..|||..:.....:|.|        || .|.:|
Mouse   414 -ED--------HCSIAQQRNMAQHFRKVLGDTLLTKPVDIAAD--------GLPSPNQL------ 455

  Fly   846 TVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMT 910
                       :|:..:..:.:.:..|.....|.:.         |::.||:          |..
Mouse   456 -----------RRKILIKHKKLAEGSAYEEVPTSVM---------YSENDIS----------NSI 490

  Fly   911 TRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEIN 975
            ....:.:.|...|..|....|:   |.|.:..|....|.....:|..|  .|....|::..||..
Mouse   491 KNGILYLEDPVNHEWYPHYFVL---TSSKIYYSEETSSDQGNEDEEEP--KEASSSTELHSSEKW 550

  Fly   976 FEWSLPSS-EANGVIRQFSIAYTNINNLTDAGMQDFESEEAFG--VIKNLKPGETYVFKIQAKTA 1037
            |...|.:. :...:..:....|.......|......|||...|  .:...:.|:....:|.::..
Mouse   551 FHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQD 615

  Fly  1038 IG---------------FGPEREYRQTMPI--------LAPPRPATQVVPT-EVYRSSST----- 1073
            .|               :.....|:| :|:        |:.|.|.|....: |.|.:|.|
Mouse   616 AGTPKFFLTDNLVFDSLYDLITHYQQ-VPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAE 679

  Fly  1074 ----------------------IQIRFR-----KNYFSDQNGQVRMYTIIVAEDDAKNASGLEMP 1111
                                  ..|.||     |:....|.||    |:::...        |..
Mouse   680 HMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQ----TVMLGNS--------EFD 732

  Fly  1112 SWLDVQSYSVWLP-YQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSG----------- 1164
            |.:|:.||....| |:.:...||....::|  .|||...|       .|.|..|
Mouse   733 SLVDLISYYEKHPLYRKMKLRYPINEEALE--KIGTAEPD-------YGALYEGRNPGFYVEANP 788

  Fly  1165 -TTYRVKVRAFTGADKFTDTAYSFPIQTDQDNT---SLIV-------------------AITVPL 1206
             .|::..|:|.          :.:..|.:.:.|   |.|:                   .:..|.
Mouse   789 MPTFKCAVKAL----------FDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPS 843

  Fly  1207 TIILVLLVTLLFYKRRRN------------------NCRKTTKDSRAND-----NMSLPDSVIEQ 1248
            ..:..::...:....|.:                  .|:...:....|:     ::|:| ||.:.
Mouse   844 NYVEEMINPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMP-SVAQW 907

  Fly  1249 NRPIL------IKNFAEHYRLMSADSDFRFSE------------EFEEL-----------KHVGR 1284
            :..:.      ::::.:..|.::..:|.|.:|            |..||           :.:|.
Mouse   908 SLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGT 972

  Fly  1285 DQPC---------TFADLPCNRPKNRFTNILPYDH---SRF--KLQPVDDDE---------GSDY 1326
            ::.|         |.|:...|:.|.:  ..|.|:.   ||.  |.|.:|...         ||..
Mouse   973 ERACYRDMSSFPETKAEKYVNKAKGK--KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQL 1035

  Fly  1327 INANY---------------VPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFE- 1375
            :..|:               ..||..   :::....:   ||:.:....:|:.|.:.....|.|
Mouse  1036 VALNFQTPDKPMQMNQALFMAGGHCG---YVLQPSTM---RDEAFDPFDKSSLRGLEPCVICIEV 1094

  Fly  1376 KGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWP----D 1436
            .|.    ::.|.:...:....:::::....:.:....|||::..|..         ..||    .
Mouse  1095 LGA----RHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLN---------PVWPAKPFH 1146

  Fly  1437 FGVPNPPQTLVRFV 1450
            |.:.||....:|||
Mouse  1147 FQISNPEFAFLRFV 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470	5/11 (45%)
		FN3	405..494	CDD:238020	17/90 (19%)
		FN3	511..574	CDD:238020	13/72 (18%)
		FN3	583..671	CDD:238020	16/99 (16%)
		fn3	683..753	CDD:278470	17/88 (19%)
		fn3	787..850	CDD:278470	11/63 (17%)
		fn3	866..935	CDD:278470	10/68 (15%)
		fn3	961..1043	CDD:278470	15/99 (15%)
		PTPc	1272..1525	CDD:214550	42/245 (17%)
		PTPc	1298..1525	CDD:238006	33/187 (18%)
Plcg1	NP_067255.2	PH_PLC_gamma	29..151	CDD:270168	26/133 (20%)
		PH	<71..142	CDD:278594	17/99 (17%)
		PI-PLCc_gamma	319..>466	CDD:176534	36/216 (17%)
		PH-like	489..>523	CDD:302622	7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..545		5/24 (21%)
		SH2_N-SH2_PLC_gamma_like	545..649	CDD:199829	16/104 (15%)
		SH2_C-SH2_PLC_gamma_like	663..765	CDD:198186	22/115 (19%)
		SH3_PLCgamma1	791..850	CDD:212903	8/68 (12%)
		PHsplit_PLC_gamma	<864..933	CDD:270054	7/69 (10%)
		PH	<872..929	CDD:278594	7/57 (12%)
		PLCYc	954..1069	CDD:128454	20/119 (17%)
		C2_PLC_like	1087..1211	CDD:175974	16/87 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910