DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and R155.3

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_497485.1	Gene:	R155.3 / 187909	WormBaseID:	WBGene00020117	Length:	1165	Species:	Caenorhabditis elegans

Alignment Length:	1244	Identity:	228/1244 - (18%)
Similarity:	408/1244 - (32%)	Gaps:	389/1244 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 TRPSSPIIEDLKSIRMGLNISWKSDVNS---KQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQP 555
            |.|.....:|..:...||.:.|.| :|:   :...:..|.||...:|       |.||.:..|:.
Worm     9 TVPKDDAYKDELNTLKGLAVDWGS-INTLIDELSNFLELSSRLSMND-------EMRLHLIKLKA 65

  Fly   556 GAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRT 620
            ...|...:..|.::..|:.                 |||:::.|:..            |::...
Worm    66 SVTYTQTLSLVKYNNYSQK-----------------ETVKNSEVVYS------------SLQKVY 101

  Fly   621 DSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDS 685
            .|......|||..|....|.||....:.:|:    |...:||            .:..:.:|:.|
Worm   102 TSSIALSELPSKASNGDKIIDMLNSFEKSIK----SLTEDSP------------SIGTLYELLKS 150

  Fly   686 RNITLEWPKPEGRVESYILKW---------------------WPSD------------------- 710
            |::         ||.|..||.                     |..|
Worm   151 RHL---------RVSSVALKHVSGFLNGHSDILHLFKDLEDKWIKDAVRDHSGNLANALNQLKTF 206

  Fly   711 --NPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQS 773
              :..:|....|||....:::|.:|..|.:..              |:...|.:|..:...::.:
Worm   207 EASTRKVHQSFVSEAVMLEEVSKIRSKIPKYS--------------GLADKIATLPSKIHEILGT 257

  Fly   774 -DVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFS-----------LGD-AEIRD---KEKLA 822
             .|.:...:|:.....|.|......|..:...:..||           ||: .||.:   |.:|.
Worm   258 PSVKLPTSDKDKVDKAIPLMAQLPAQLKALEKLMNFSEQLKLPENAKKLGNIIEIVNQDGKNQLE 322

  Fly   823 N-------DTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEI 880
            |       .||.|..:|.|:|.:                          :.:..|....|.:|..
Worm   323 NTLKMFKSSTDVKEIYTLLLPVK--------------------------DTLELLKDNPIHETAA 361

  Fly   881 SLRWDLPKGEYNDFDIA-YLTADN---------LLAQNMTTRNEITISDLRPHRNYTFTVVVRS- 934
            ::...|.|.|....|:| :.||.|         |:...:||..::.:|    :..:..|.|:.:
Worm   362 NIISSLDKVEKFAQDMADFFTALNSIRQIEESSLIIPVITTIRQLRLS----NDQFGLTTVLNNL 422

  Fly   935 ---GTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEI--------------NFE----- 977
               .|:.|.|  :|.:::...|..|....::.|....:....|              :|:
Worm   423 PMIKTQLSSL--TSYINSVKKTKHAETDALKDFEKIGLHSRVIGTATRGISNMQKLVDFKDLADI 485

  Fly   978 WSLPSSEANGVIRQFSIAYTNINNLTD-AGMQ---DFESEEAFGVIKNLKP------GETYVFKI 1032
            ..|..||...|..|.:  ..|:.||.. ||::   ...|.|..|..|::||      .:...|.:
Worm   486 GDLVKSEVEKVKDQLN--DENVANLKALAGIEGQLKTASGEIVGYKKSVKPVTSTSLPDYSTFFL 548

  Fly  1033 QAKTAIGFGPEREYRQTMP-ILAPPRPATQVVPTEVYRS--SSTIQIRFRKNYFSDQNGQVRMYT 1094
            .||...|...:      :| |::.......:||....|:  |||               |:..|.
Worm   549 DAKKVKGINLK------LPAIISSMEKLNNLVPIRSSRATRSST---------------QLDGYL 592

  Fly  1095 IIVAEDDAKNASGLEMPSWLDVQSY-SVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCN 1158
                               |.:||. |:.|.:......:....:|::|..:.....:|
Worm   593 -------------------LSLQSLSSISLDFTKFHKSFDGSTQSLQDLGVSFAKYNN------- 631

  Fly  1159 GPLKSGTTYRVKVRAFTGADKF---TDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLV--TLLF 1218
                    ...|.:|...|.|.   :.:|........:.|:::::.:...:..|.|:|:  :..|
Worm   632 --------TLTKQKAAAAAQKSGGGSSSASGGSQGVFESNSTIVLIVFGCIVFICVILIPASSWF 688

  Fly  1219 YKRRRN----NC-----------RKTTKDSRANDNMSLPDSVIEQNRPILIKNFAE---HYRLMS 1265
            |..:::    .|           :|..|....:...:.|:..:|:.:...||:..:   ...:.|
Worm   689 YLHQKDPAARKCFAIRELPMEEVKKPVKKKDVSKMDNKPERELEKTQDESIKDVPKLILELDMSS 753

  Fly  1266 ADS--DFRF---------------SEEF-------------EELKHVGRDQPCTFADLPCNRPKN 1300
            |:.  |.|:               |||.             |:.:..||:.      |...:.|.
Worm   754 AEKYVDCRYEALQDMHKETCIPFLSEELIKKFYGVKFDAMNEKYEVPGREA------LKSEQMKQ 812

  Fly  1301 RFTNILPYDHSRFKLQPVDDDEGSDYINANYVP-GHNSPREFIVTQGP-------LHSTRDDFWR 1357
            |....|..| :|..|:........|||:||.|. .|.  .:.|::|.|       ..||.:.:|.
Worm   813 RLPIPLVMD-TRVVLKDYGTLFNDDYIHANRVTCSHG--LQLILSQAPQEANGESCESTIESYWW 874

  Fly  1358 MCWESNSRAIVMLTRCFEK--GR-EKCDQYWPNDT-VPVFYGDIKVQILNDSHYADWVMTEF-ML 1417
            ...:..|..:||:....||  |: ..|.:|:|... ..:.:.::.|:..:.....|:...|. :.
Worm   875 TAKQEKSTQLVMMCDFDEKCPGKTNSCARYYPESVGESMKFKNLTVECKSKIAEKDFETRELEVK 939

  Fly  1418 CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITL- 1481
            ..|.|...:.|.....|....|  .|.||:  ..:...:|.....|::|||..|:.||..|.::
Worm   940 FDGHEPHTVTHSRLVGWNPLNV--QPDTLL--FTSLIQKIKNSTTPVMVHCIDGISRSAAFASMI 1000

  Fly  1482 ---DRILQQINTSDYVDIFGIVYAMRKERVWMV-----------------------QTEQQYICI 1520
               ..::|.:.:   |.:..:|..:|.:|...:                       |..:..:..
Worm  1001 IGYQLVIQSLGS---VKLEAVVSYIRSQRAMAITSALELAFVDAGIVKLLGLFVDAQQNKGELTR 1062

  Fly  1521 HQCLLAVLE 1529
            .||:||..|
Worm  1063 EQCILAQQE 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020	228/1244 (18%)
		FN3	511..574	CDD:238020	15/65 (23%)
		FN3	583..671	CDD:238020	17/87 (20%)
		fn3	683..753	CDD:278470	16/111 (14%)
		fn3	787..850	CDD:278470	18/84 (21%)
		fn3	866..935	CDD:278470	17/82 (21%)
		fn3	961..1043	CDD:278470	23/110 (21%)
		PTPc	1272..1525	CDD:214550	63/320 (20%)
		PTPc	1298..1525	CDD:238006	56/266 (21%)
R155.3	NP_497485.1	PTPc	802..1045	CDD:214550	55/258 (21%)
R155.3	NP_497485.1	PTPc	821..1032	CDD:238006	50/220 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910