DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and F40G12.10

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_506537.1	Gene:	F40G12.10 / 179927	WormBaseID:	WBGene00009605	Length:	438	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	72/376 - (19%)
Similarity:	135/376 - (35%)	Gaps:	92/376 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1214 VTLLFYKRRRNNCRKTTKD----SRANDNMSLPDSVIEQNRPILIKNFAEHYRL---MSADSDFR 1271
            :|...:|.::....|..|:    |::...::|..:....:....:||..:..::   :....|||
Worm    74 ITAKGFKSKKGKKLKKKKEETSASKSPSTLTLGKAESHMDFSGNVKNVEKGVKVWIELLEKMDFR 138

  Fly  1272 FSEEFEELKHVGRDQPCTFADL-PCNRPK-----NRFTNILPYDHSRFKLQPVDDDEGSDYINAN 1330
            .:.| .|.|.:...:    ||| .|...|     ::..|:..||.:|.|        |....:..
Worm   139 KTME-PEFKPIDTMK----ADLEKCQAFKKNIDFSQSENVELYDTNRVK--------GGGEADFF 190

  Fly  1331 YVPGHNSP-------------REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCD 1382
            |   |.|.             .:..:...|  .:.:.||.|......:.:.:|.     |.|:.|
Worm   191 Y---HGSTLTIPSVTTKSTILAQLAIVDSP--QSLESFWIMVASQKIQRLFILL-----GEEELD 245

  Fly  1383 -----QYWPND-------------TVPVFYGDIKVQIL-----NDSHYADWVMTEFMLCRGSEQR 1424
                 :|:|.|             |||........|:.     .|...|.:.|.|  :|
Worm   246 KPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIE--IC------ 302

  Fly  1425 ILRHFHFTTWPDFGVPNPPQTLVRFVRA--FRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQ 1487
                   ..|||..:|......:....|  |...|..:....:| .:.|.||:|:|......:::
Worm   303 -------DFWPDAKIPTMGYNRIAATAASVFESDIDCDASCAIV-SNYGAGRAGSFFVAVLAIEK 359

  Fly  1488 INTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPA 1538
            :...:..:|..|..::|.:|...::|..||:..:  ::|:..|.:::..||
Worm   360 LQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTY--VIALTYGLKHVKDPA 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	57/296 (19%)
		PTPc	1298..1525	CDD:238006	50/269 (19%)
F40G12.10	NP_506537.1	PTPc	144..397	CDD:214550	56/292 (19%)
F40G12.10	NP_506537.1	PTPc_motif	305..397	CDD:214649	20/94 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910