DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and igdb-2

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001255649.1	Gene:	igdb-2 / 178199	WormBaseID:	WBGene00007736	Length:	1526	Species:	Caenorhabditis elegans

Alignment Length:	1134	Identity:	217/1134 - (19%)
Similarity:	382/1134 - (33%)	Gaps:	379/1134 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 TTAPDPPSNLSVQVRSGKNAIILWSPP-----TQGSYTAF-KIKVLGLSEASSSY---------- 168
            |:.|...:..|..|...||...|  |.     |..:.|:| ..|:..::|..||:
Worm   456 TSVPSVRNIASTNVHMVKNNASL--PDSMKCCTDANVTSFCSSKMCNVAEDPSSFSTITIATTCR 518

  Fly   169 --------------NRTFQVNDNTFQHSVKELTPGATYQVQAYTI----YDGKESVAYTSRNFTT 215
                          |.|........||...|:..|:|.::..:::    .|.:.......:.:.|
Worm   519 AEWPKVSPCIADGRNHTDCCLKKGVQHDCLEICSGSTKELGVHSVLCLNLDLQAIYQCIRQGYET 583

  Fly   216 KPNTPGKFIVWFRNETTLLVLW-QPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAF 279
            .|:.||...:......::.|.| :|...|.:..:|.:.|...:..::|..|:....|     ...
Worm   584 HPSAPGNVTISELTAHSVTVQWTEPNSNAHLVENYTLFIRKNEHGEAVRTVKNVISP-----HVE 643

  Fly   280 KGLVPGRAYNISVQTMSEDEISLPTTAQ-YRTVP-LRPLNVTFDRDFITSNSFRVLWEA----PK 338
            .||.|...|.:::|:.|.:..|||:||: :.|:| .||...|.......::...::.:|    |.
Worm   644 LGLDPDSEYVLTLQSHSANGTSLPSTAKLFSTLPTTRPPLCTIGEPIYMNDGRVMICDAVNPCPN 708

  Fly   339 GI---------------------SEFDKY-------QVSVATTRRQSTVPRS------------- 362
            |.                     .||...       :..:::.:...|:|.|
Worm   709 GFRCTGAGSDLSYCCPHDGTHSSEEFTSCCKEQKMPESCMSSCQYNMTLPESCKENLNTWVQCAS 773

  Fly   363 --NEPVAFFDFRDIAEPGKT-----FNVIVKTVSGKVTSWPATGDVTLRPLP--VRNLR--SIND 416
              ::.:......::::|.:|     |.|.......:|:.:........:.||  |||:.  ||:.
Worm   774 EGHDHLRCCLQEEVSKPCQTACMHPFTVPADECFSEVSKYRTCFSAAHQALPAAVRNVEVSSISK 838

  Fly   417 DKTNTMIITWEADPASTQDEYRIVYHELETFNGDTSTLTTDRTR---FTLESLLPGRNYSLSVQA 478
            |...   |:||      ..|..|:...::.|....:.:.|:.:.   |....|.|.::||:.|.|
Worm   839 DSAT---ISWE------DLEANIIVFRVQLFEKGGNLIKTENSSADIFRFIDLEPNKDYSVRVTA 894

  Fly   479 VSKKMES----NET------SIFVVTRPSSPIIEDLK-SIRMG--LNISW-------KSDVNSKQ 523
            ::...|.    |.|      .|:...||.:|  |.|: |...|  :|::|       .::|.:|.
Worm   895 INFLGEGPPSWNATFTTKPAQIYEGDRPVAP--EKLRISWNSGPRVNVTWDPVSVRRNAEVVTKP 957

  Fly   524 EQYEVLY-SRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPR 587
            .:|.:.| ....:|...|.:|.::.:|:::|:..|.|               :.|..|...|
Worm   958 IEYTIYYLDTEQSSTWTTLRTNQTWVVMRDLRKDALY---------------YVYVTAKEDN--- 1004

  Fly   588 NMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITD--MTKGEKYTI 650
                .|.||:|::...:..:|....|.:|                 ..|.|..|  .:.|||.:|
Worm  1005 ----RTSRSSSIITILAQKDSPGLPEPTI-----------------VIEPDHKDGVFSPGEKISI 1048

  Fly   651 QVNTVSFGVESPVPQ-----EVNTTVPPNPVSN------II------QLVDSRNITLEWPKPEGR 698
            ..:         :|.     .::.||..:.|.|      :|      :.:|:....:
Worm  1049 NCS---------LPNIKKHLNIDLTVGSHVVQNDHGALWVILETEADEAMDTATCAV-------- 1096

  Fly   699 VESYILKWWPSDNPGR--VQTKN-VSENKSA-----------DDLSTVRVLI---GELMPGVQYK 746
                      ||..||  |..|: |.|.|::           ||.|.....|   |.|.|.:.::
Worm  1097 ----------SDTDGRQHVAMKHLVLERKASVTMKKDKIRVLDDQSVEIECIYRGGGLDPKISFE 1151

  Fly   747 FDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLG 811
            .|.:..|.|.|:                      .|:.|...:           :|:.|.:....
Worm  1152 KDGKKASRGFLN----------------------LKKTEAGYV-----------AKWHIRKVKQE 1183

  Fly   812 DAEIRDKEKLANDTDR-----KVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQ-- 869
            ||........::|..|     :|.|:                  ..:||:.      |:.|.|
Worm  1184 DAGFYKCVVTSSDGSRVEASSEVIFS------------------TETLPVN------PKLILQCC 1224

  Fly   870 ---------LHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITI----SDLR 921
                     |.|.||..|.:|::                      .|| .||..:::    ||:|
Worm  1225 EDEGITGDCLQACNIGRTSLSIK----------------------NQN-CTRFAVSLLKCASDIR 1266

  Fly   922 PHRNYTFTVVVRSGTESSVL-----RSSSP-----------LSASFTTNEAVPGRVERFHPTDVQ 970
            .|.:    ..:.||..|..|     .|.||           ::.|..::|..|..|....   ::
Worm  1267 DHSD----CCIASGVTSKCLPLCSGDSFSPDIDCSEHAVSIMTCSVKSHEHAPSEVSNVR---IK 1324

  Fly   971 PSE--INFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIK-----NLKPGETY 1028
            .||  :|.||..|.::.   .:.|::.|...::       |.|.......|:     ::.|.|.|
Worm  1325 ASEGKVNIEWDYPLTKD---YKYFAVYYRKAHD-------DHEDWHKLKTIQQNIELDVDPSEDY 1379

  Fly  1029 VFKIQAKTAIGFGPEREYRQTMPILAPPR 1057
            ...|.|..|:|.  .|.....:|..:.||
Worm  1380 EVGILAANALGH--SRLMYSAIPKDSEPR 1406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	21/114 (18%)
		fn3	220..304	CDD:278470	19/84 (23%)
		fn3	315..391	CDD:278470	14/127 (11%)
		FN3	405..494	CDD:238020	26/105 (25%)
		FN3	511..574	CDD:238020	13/70 (19%)
		FN3	583..671	CDD:238020	16/94 (17%)
		fn3	683..753	CDD:278470	18/86 (21%)
		fn3	787..850	CDD:278470	8/67 (12%)
		fn3	866..935	CDD:278470	16/83 (19%)
		fn3	961..1043	CDD:278470	19/88 (22%)
		PTPc	1272..1525	CDD:214550
		PTPc	1298..1525	CDD:238006
igdb-2	NP_001255649.1	DB	189..280	CDD:279948
		FN3	<413..467	CDD:238020	2/10 (20%)
		DB	484..577	CDD:279948	15/92 (16%)
		FN3	585..675	CDD:238020	23/94 (24%)
		Lustrin_cystein	684..724	CDD:291299	4/39 (10%)
		DB	737..818	CDD:279948	8/80 (10%)
		FN3	825..911	CDD:238020	24/94 (26%)
		FN3	922..1015	CDD:238020	26/116 (22%)
		ig	1125..1198	CDD:278476	18/105 (17%)
		DB	1223..1306	CDD:279948	21/109 (19%)
		FN3	1315..1392	CDD:214495	20/91 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910