DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptp-4

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001255470.1	Gene:	ptp-4 / 177898	WormBaseID:	WBGene00010558	Length:	1159	Species:	Caenorhabditis elegans

Alignment Length:	1118	Identity:	240/1118 - (21%)
Similarity:	416/1118 - (37%)	Gaps:	319/1118 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 RNMTIETVR----SNSVLVHWSP--------------PESGEFTEYSIRYRTDSEQQW------- 626
            :|.|...:|    .|.:..|.:|              .:......|......||.:||
Worm    27 KNATEALLRCPPAENFIRTHMAPDFETPRLVRRLDWFQDDSLVASYQQDILADSSRQWWVSDGRY 91

  Fly   627 --VRLPSVRSTEADITDMTKGE-KYTIQVNTVSFGVESPVPQEVNTTVPP-NPVSNIIQLVDSRN 687
              :| |......:.:|....|. :..::.:.:....:|...||:...|.| .|.|..|:...:|:
Worm    92 QLIR-PFYTLRVSPVTPEDSGTYRCRLETDPLFSSPQSTATQELAVMVKPVAPSSPEIKTFTNRS 155

  Fly   688 ITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENK---SADDLSTVRVLIGELMPGVQYKFDI 749
            |||.|.....|....||::       .|..:.||:|.   .|...:...|::..|.|...|.|.:
Worm   156 ITLVWTHNAARAHRPILRF-------SVSVRTVSDNTRFVMAAPSNATTVIVDNLSPYTLYAFSV 213

  Fly   750 Q------TTSYGILSGITSL--YPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIY 806
            :      ::.:|..:...:|  .|...|.||.   :.|...|    .:.::.||..:.:.:.|.|
Worm   214 RAENSAGSSDFGPETTFRTLGESPNRPPQIQK---IRNITSE----CVEVTITPPDEMNGELDKY 271

  Fly   807 RFSLGDAEIRDKEKLANDT-DRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQL 870
            ...:         :..|:| .||:||
Worm   272 LVLI---------QAVNETIPRKMTF--------------------------------------- 288

  Fly   871 HATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSG 935
                          |.|                       |...:||..|.|..:|...:...:|
Worm   289 --------------DKP-----------------------TSTPLTICALSPSTDYALAIEADNG 316

  Fly   936 TESSVLRSSSPLSASFTTNEAVPGRVERFHPTDV-------QPSEINFEWSLPSSEANGVIRQFS 993
                 ..:|...:..|.|.::||    .:.|:.:       :| ||...|..|...|...:.::.
Worm   317 -----FGTSPQATLVFHTEDSVP----NWSPSTITTLPVVGKP-EITVLWPAPPLNATEKVIKYH 371

  Fly   994 IAYTNIN---------NLTDAGMQD--FESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYR 1047
            :.|...|         |::..|::.  |:..     :.:|.|...|..::.|.|..|.|.:
Worm   372 LYYKAKNEDQWKIEHLNVSPNGVKSKLFKYR-----LVDLNPNTQYRIRVSASTIKGEGAQ---- 427

  Fly  1048 QTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRM---------------YTIIV 1097
                      .|..|..|:|....:   :.|:...|..:|| |::               :|:.|
Worm   428 ----------SADSVAQTDVGEPGT---VTFKDLNFDCKNG-VKLRWNYEPSVNSKKSPTFTVKV 478

  Fly  1098 AEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPY----YPFENRSVEDFT--IGTENCDNHKIGY 1156
            ............|.| ||:...|::      |.|    ...|..::::.|  || :..|:|:.
Worm   479 TNQTTSLQFNTTMLS-LDIIDLSLY------DEYTLRIIVLERSTIDNSTILIG-KYSDSHQF-- 533

  Fly  1157 CNGPLKSGTTYRVKVRAFTG----ADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLV--T 1215
               .||...:|:   .:|..    ..|.|.:|         .|...|..:.|...||:...:  .
Worm   534 ---ILKDKCSYQ---SSFCSPGEKCAKLTSSA---------GNPRYISVLIVIFAIIIFAFICFV 583

  Fly  1216 LLFYKRRRNNCRKTTKDSRA---NDNMS--LPDSVIEQNRPI-LIKNFAEHYRLMSADSDFRFSE 1274
            ::.:.|...|.:...|....   .:.:|  :.||..:::.|: |...:.|.   ::.:...:|..
Worm   584 IVHFARGSMNFKHLLKKKEKCVYLEEISPLVYDSAGQEDIPVELFYGYVED---LNRNDSLKFKT 645

  Fly  1275 EFEELK-------HVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYV 1332
            :|:.|:       .|...:..:.:|.  |..|||:.||...:.:|.:|   :...|:||||||||
Worm   646 QFQILESQTSGIDSVDSGESNSSSDE--NSQKNRYNNIGAIEATRIRL---NSPTGNDYINANYV 705

  Fly  1333 PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPN-DTVPVFYGD 1396
            ...|....:|.||.||.||..|||.|.|:..|..||.:|...|.|:.|||||||: ...|..:|:
Worm   706 DSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGN 770

  Fly  1397 IKVQILNDS---HYADWVMTEFMLCRG--SEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRD- 1455
            .:|.::::|   |::..:: :..:.:.  :.:|.:...||..|||.|||:....|:.||....|
Worm   771 YQVTLVSESTNAHFSHRIL-DLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDI 834

  Fly  1456 -RIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYIC 1519
             ..|    |:||||||||||||::|.:|.:.:.:.:...:::.|.:..||::|..:|||.:|||.
Worm   835 HSTG----PVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIF 895

  Fly  1520 IHQCLLAVLE------------------GKENIVGPAREMHDNEGYEGQQVQLDE---------- 1556
            .|:.:..::.                  .:||:.|..|          .|:|.::
Worm   896 CHEAIRQLIRHGITRVHSDLFMRYLHYLSEENLNGKTR----------MQLQFEDICDCKHQPRC 950

  Fly  1557 --NGDVVATIEGH 1567
              ..||: |:.|:
Worm   951 LIESDVI-TLPGY 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	18/111 (16%)
		fn3	683..753	CDD:278470	18/78 (23%)
		fn3	787..850	CDD:278470	10/63 (16%)
		fn3	866..935	CDD:278470	8/68 (12%)
		fn3	961..1043	CDD:278470	19/99 (19%)
		PTPc	1272..1525	CDD:214550	93/267 (35%)
		PTPc	1298..1525	CDD:238006	87/234 (37%)
ptp-4	NP_001255470.1	IG_like	<83..120	CDD:214653	6/37 (16%)
		FN3	140..232	CDD:238020	23/98 (23%)
		FN3	237..326	CDD:238020	26/185 (14%)
		FN3	338..435	CDD:238020	21/116 (18%)
		PTPc	642..900	CDD:214550	93/267 (35%)
		PTPc	675..900	CDD:238006	87/232 (38%)
		Y_phosphatase	<977..1128	CDD:278528
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910