DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and F57H12.5

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_501331.1	Gene:	F57H12.5 / 177592	WormBaseID:	WBGene00019020	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	364	Identity:	74/364 - (20%)
Similarity:	131/364 - (35%)	Gaps:	94/364 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1220 KRRRNNCRKTT------------------KDSRANDNM--SLPDSVIEQNRPILIKNFAEHYRLM 1264
            |..|.:||:.:                  |.|:....|  .:|.::...|:...|:...|.:..:
Worm   164 KEVRKDCRENSVYFMERSDEKGVKKKHSKKHSKQKTKMWLGMPSALNFCNKNNDIQKIREEFGFL 228

  Fly  1265 SADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKL-QPVDDDEGSDYIN 1328
            .:....:.:|.||                 .|:.:||......||.:|.:| :|..:|  .:|||
Worm   229 DSLVCNKTTEAFE-----------------ANKVRNREGCPKIYDENRVQLNRPGHED--VNYIN 274

  Fly  1329 ANY------------VPGH-----------NSPREFIVTQGPL---HSTRDDFWRMCWESNSRAI 1367
            |:.            ||.:           ....:.||.|.|.   .|..:|||.|.::.....:
Worm   275 ASVITLTDVCRRMACVPAYVHLVVLYFVIFQFEHKLIVAQLPQMENESFVEDFWYMIYQEQIHLV 339

  Fly  1368 VML----------TRCF--EKGREKCDQYWPNDTVPVFYGDIKVQILND-SHYADWVMTEFMLCR 1419
            .::          |..|  |.|..   ||    |..:|..:.:..:..| ..|...|:.|    .
Worm   340 YLMVPDDKLKNTTTSLFNDENGGY---QY----TGKMFINNRRADVSGDPKEYTIEVLPE----G 393

  Fly  1420 GSEQRILRHFHFTTWPDFGVPNPPQTL--VRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLD 1482
            .|:..|.:..|...|..  :..||:||  ::.:..|......:...:.|....|.||:.:||...
Worm   394 NSDSVICQVHHHAPWKH--LQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGAL 456

  Fly  1483 RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIH 1521
            ..:.|:|.....:|..|:..::::|...|::..||..|:
Worm   457 YAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIY 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	63/292 (22%)
		PTPc	1298..1525	CDD:238006	59/266 (22%)
F57H12.5	NP_501331.1	PTPc	220..500	CDD:214550	64/308 (21%)
F57H12.5	NP_501331.1	PTPc	255..498	CDD:304379	57/256 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910