DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Y69A2AR.19

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_500211.3	Gene:	Y69A2AR.19 / 177036	WormBaseID:	WBGene00022090	Length:	1338	Species:	Caenorhabditis elegans

Alignment Length:	1550	Identity:	299/1550 - (19%)
Similarity:	519/1550 - (33%)	Gaps:	516/1550 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 NISVQTMSEDEISLPTTAQYRTV--PLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVA 351
            ::..:.::::.:..|.:..:..:  ||.|:......||:..:..::.....:..:..|...
Worm    32 SVRQEKINDNHLDSPRSDGHELMENPLDPIASHDFSDFLDPHELQIAGRVARQDNNNDHLD---- 92

  Fly   352 TTRRQST----VPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLR 412
             |.|.|.    |....||....||.|::.|.:..:|      |:|.....|.||. .|..|.:|.
Worm    93 -THRSSAGHELVDSPLEPRDSHDFLDLSTPQELQDV------GRVARQEQTYDVD-TPSSVESLD 149

  Fly   413 SINDDKTNTMIITWEADPASTQD---EYRIVYH-----------------------ELETFNGDT 451
            ..:|...|...:..:..|:.:.|   ...::.|                       ||..|.
Worm   150 IPSDTSNNAGRVARQVAPSKSADYLNHTTLIAHIANGIALQAGLMKGSIPIDAAVSELLNFG--- 211

  Fly   452 STLTTDRTRFTLESL--LPGRNYSLSVQAVSKKMESNETSIFVVTRPS--SPIIEDLKSIRMGLN 512
            |...:|.|.|..:.:  |.|:     ::.|...:.|.:..:.:.||..  :.::...|||....:
Worm   212 SVKVSDITAFKPDQITALIGK-----LKGVPASLVSTDPIVTLETRALDWNKLLIASKSIGDVAS 271

  Fly   513 ISWKSDVNSKQEQYEVLY---SRNGTSDLRTQKTKE-SRLVIKNLQPGAGYELKVFAVSHDLRSE 573
            :..|.|.:::..::|..:   |.:.|:|......|. |.|:.|:                |...|
Worm   272 LPGKDDFSTELAKFENTFNFDSLSKTADTINSTIKSCSNLLDKS----------------DTSWE 320

  Fly   574 PHAYFQAVYPNPPRNMTIETVRSN-----SVLVHWSPPESGEFTEYS----IRYRTDSEQQWVRL 629
            .|:..:  :.:.|.  |:||:.|.     ::.|.:....:| ||.:.    :.:..:..:.::.:
Worm   321 SHSAIR--FKDLPG--TLETLGSKVKEIINMDVSFDKLMNG-FTAFQPLERLMHLVELRRSYIIV 380

  Fly   630 PSVRSTEADITDMTK-----------GEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLV 683
            |.  |...|||...|           ..|.::.|:.:: .|....|:..::....:.:|.:.|||
Worm   381 PV--SNTPDITSNLKKVVEQVALAKAAGKSSMTVSALA-DVGGSKPKREHSVGFQSGISELKQLV 442

  Fly   684 DSRNITLEWPKPEGRVESYILKWWPSD--NPGRVQTKNVSEN-----KSADDLSTVRVLIGELMP 741
            ..                 :|..|.|.  |....|..|:::.     |:.|.||.:.   .:|.|
Worm   443 KD-----------------VLDPWFSSLLNVTSAQQNNLADGLQSLFKTTDQLSRMN---DKLKP 487

  Fly   742 GVQYK-------FDIQTTSYGILSG----ITSLY------PRTMPLIQSDVVVANGEKEDERDTI 789
            .|...       |.:......:||.    ::|:.      .||:|:....||.....|......:
Worm   488 IVSSSVQQTIAVFQVLVNEISLLSSDSAEMSSVMAELDKCSRTLPMDDQRVVGVELMKHINSLKL 552

  Fly   790 TLSY-----TPTPQSSSKFDI------YRFSLGDAEIRDKEKLANDTDRKV-------------- 829
            :||.     |.|..:|.:.:|      |:||    :::|....|.:....|
Worm   553 SLSQFAEFKTSTILNSLEKEITSFQNSYKFS----DLQDPTATATEVKAVVESIQKSGSLEKFKQ 613

  Fly   830 -------TFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLP 887
                   ||..:....|..:    :.||:                 :...|.|.|:..
Worm   614 YLLLLQKTFADVDGNNLKTV----ILGGI-----------------KARITKIGDSTF------- 650

  Fly   888 KGEYNDFDIAYLTADNLLAQNMTTRN-EITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASF 951
             |::...::...|.  |.||...:|. ...|...:..|.....::...|:.:|.:   |..:...
Worm   651 -GDFIKEELKVHTC--LKAQEEQSRKLSQAIQATQSLRKLDEKMLEEVGSAASAV---SSFAKDL 709

  Fly   952 TTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDA----------- 1005
            .|.:::|..:::                    ||.||       .|::|.:.||
Worm   710 ATIKSIPETMKK--------------------EAKGV-------STDLNGMADAKKNSDSVGQSV 747

  Fly  1006 -GMQD----FESEEAF-----------GVIK---------------------------NLKPGET 1027
             .:||    .|.|.|.           |.||                           .||..:.
Worm   748 SSLQDASELIELESAIKELKGFGPEIDGYIKAVKSPEDRKAIETQWGNHHSDMASLESGLKAAKG 812

  Fly  1028 YVFKI---QAKTAIGFGPEREYRQTMP------------------ILAPPRPATQVVPTEVYRSS 1071
            :|.||   :|||...:|......:.:|                  .|.||:
Worm   813 FVDKIDVSKAKTMSDYGTPLANLKDLPDVKINALEKIKALDALIKALPPPK-------------- 863

  Fly  1072 STIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFEN 1136
                   ||...||..      |::.|   ||  |.||..:.||:|
Worm   864 -------RKRATSDPK------TVMEA---AK--STLEKIAALDLQ------------------- 891

  Fly  1137 RSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNT----- 1196
                        ..|||..|...|           .||..   |.|....|.:.|..::|
Worm   892 ------------FSNHKTQYQQAP-----------AAFKA---FHDFLAKFLVTTHSNSTGGSDS 930

  Fly  1197 ----SLIVAITVPLTIILVLLVTLLF----YKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPIL 1253
                :||:.|...:..::.:.|.:.|    |:::           :|.:.|       |....:.
Worm   931 GISITLIIIIVGSILALIGVAVGIYFGVRWYEKK-----------KAAEQM-------EHEIVVW 977

  Fly  1254 IKNFAEHYRLMSA-------------DSDFRFSEEFEEL---KHVGRDQPCTFADLPCNRPKNRF 1302
            :|  |:.|:.:.|             .:....|.|....   |...|....|    ||| |:...
Worm   978 VK--AQAYKSLEAAIIVLVASLHVVWGTQTSVSVEKSNAYLPKEKNRRPLAT----PCN-PETAV 1035

  Fly  1303 TNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSP------REFIVTQGPLHSTRDDFWRMCWE 1361
            .  :..|.:|..            |:||::  :.||      ::||.|||||.:|.||||.|...
Worm  1036 E--VMSDGTRIP------------IHANWI--NTSPDVDGNTQKFIATQGPLPNTSDDFWTMVQF 1084

  Fly  1362 SNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDI------------KVQILNDSHYADWVMTE 1414
            .....:|||.:..||..|||.:|:|..|     |.|            :.|||.||.....:..|
Worm  1085 HKVETVVMLCQFVEKEEEKCHEYFPVRT-----GQIVDLERYKLKTVTQEQILGDSTSKRTIQVE 1144

  Fly  1415 FMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFI 1479
             ...:....|.:.|:.:.:|||.|:|.........:...::    .::|||||||||:||:.:||
Worm  1145 -DTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE----SKKPIVVHCSAGIGRTVSFI 1204

  Fly  1480 TLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREM-HD 1543
            ....|...:..:..:.:...|..:|.:|...:||.:|...:....:..|..::||     :| |.
Worm  1205 ATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVYRLSKEKNI-----DMKHY 1264

  Fly  1544 NEGYE-----------GQQVQLDENGDVVATIEGHLSHHDLQQAEAEA---IDDE 1584
            .|.:|           .|:...|...||:..:|........:|.|.:|   ||::
Worm  1265 KEQFEMLDGGHKFLYLAQEQFKDGRKDVLKKLEADGEVRKAKQDEKKATTGIDED 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470	0/14 (0%)
		fn3	315..391	CDD:278470	15/79 (19%)
		FN3	405..494	CDD:238020	19/116 (16%)
		FN3	511..574	CDD:238020	11/66 (17%)
		FN3	583..671	CDD:238020	19/107 (18%)
		fn3	683..753	CDD:278470	15/83 (18%)
		fn3	787..850	CDD:278470	15/94 (16%)
		fn3	866..935	CDD:278470	11/69 (16%)
		fn3	961..1043	CDD:278470	25/138 (18%)
		PTPc	1272..1525	CDD:214550	75/273 (27%)
		PTPc	1298..1525	CDD:238006	67/244 (27%)
Y69A2AR.19	NP_500211.3	WSN	172..234	CDD:280385	11/69 (16%)
		Y_phosphatase	1018..1245	CDD:278528	73/257 (28%)
		PTPc	1019..1245	CDD:238006	72/256 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910