DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and dep-1

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001254192.1	Gene:	dep-1 / 174437	WormBaseID:	WBGene00009717	Length:	1367	Species:	Caenorhabditis elegans

Alignment Length:	1353	Identity:	370/1353 - (27%)
Similarity:	577/1353 - (42%)	Gaps:	278/1353 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 WEADPASTQDEYRIVYHELETFNGDTSTLTTDRTRFT--LESLLPGRNYSLSVQAVSKKMESNET 488
            :::..|..||....:..|:...|  .:.:::|...::  :.:|..|..||:::..    .:...|
Worm    62 YQSFAAKIQDVTENISDEVRDSN--KTFVSSDDAPYSIRIHALRAGHRYSIAIHG----QKDGST 120

  Fly   489 SIF----VVTRPSSPIIEDLKSIRMGL-----NISWKSDVNSK--QEQYEVLYSRNGTS------ 536
            |:.    ||..|.:|   |.:|:...:     ||:.::..|..  |:.:.:.|.:....
Worm   121 SLIKEESVVMDPRAP---DFRSMDSDIQVAEHNITMRTIKNDSYLQDSFSIEYRQINPDKKFPVL 182

  Fly   537 ---DLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNS 598
               |:..||..|  ..:.||..|..|.::|.|....:.|.|........|:|.:.:.|.....:.
Worm   183 QILDIPEQKNLE--FYLGNLNSGFDYSVRVIAHKDGMSSRPWISTLTTKPSPLKEVNINQNAGSC 245

  Fly   599 VLVHWSPPESGEFTEYSIRY---RTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVE 660
            |.|.|...|......|:|:|   .|.:....:.:||..|:.:....|.:||.|.| :.||..|.:
Worm   246 VEVSWQNDEFSGADFYTIQYSLQSTPNNSTNMTIPSTESSISICDSMLQGEAYQI-IATVQKGGQ 309

  Fly   661 SPVPQEVNTTVPPNPVSNIIQLVDSR----NITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVS 721
            ...|......:.|.|..:.....|.:    .:..|.| ...:::...:.....:....|...|:.
Worm   310 VSEPLITKFQLRPLPPIDFRVRADLKRGKYKLLAELP-TSSKIDKCQITVAGDEAERSVNYANIE 373

  Fly   722 ENKSADDLSTVRVLIGELMPGVQYKFDIQT----------------------TSYGIL-----SG 759
            :.||...:.....   .|.||.::.|.|.:                      .::|:.     .|
Worm   374 QTKSGHKICWFNF---ALSPGERFDFSISSMANESASQKLQKSIVLTPAFDFNAFGLTLQESNGG 435

  Fly   760 ITSLYPRT------MPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDK 818
            |..::|::      :..|.:.||.|       ...:.:..||              :|:.:..||
Worm   436 IELIWPKSEVFMTRVKDIWNKVVGA-------ESLLNMRITP--------------IGNNDETDK 479

  Fly   819 EKLANDTDRK----VTFTGLVPGRLYNITVWTVS-GGVASLPIQRQDRLYPEPITQLHATNITDT 878
             .|..:|..|    |....||.|..|.:.::||: .|:.|.....:......|...:...::|.:
Worm   480 -TLKFETSPKNIDPVFAKNLVKGACYRVQLFTVTKTGIISETRHNETIRMSSPAVNVSLESVTRS 543

  Fly   879 EISLRWDLPKGEYNDFDIAYLTADNLLAQNMT------TRNEIT--------ISDLRPHRNYTFT 929
            ..:||  :....::|.........:::.::|.      .|.::|        :..|.|...||..
Worm   544 SATLR--IVFSTHHDSTSISNCQMHIVVRDMNGKSVFDKRMQLTATFAPLLNLDGLSPFHKYTVN 606

  Fly   930 VVVRSGTESS-------VLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANG 987
            ..:..|:.||       ..|:...|  ||:|.:..|..|:......:....:...| ||.:..||
Worm   607 TQIICGSGSSETPQCPAATRTMRQL--SFSTRQDKPAAVQDLKVEPLNSYSVMLTW-LPPALPNG 668

  Fly   988 VIRQFSIAYTNINN----LTDAGMQDFESEEAFG-VIKNLKPGETYVFKIQAKTAIGFGPEREYR 1047
            ::..:::..|.|.:    ..|.|:....|:.... ||..|..|.||.|.::|.|..|||......
Worm   669 ILTHYAVNVTKIGSDETRTIDVGVSSNRSDHTVQVVIDELFGGHTYSFSVRAVTEAGFGENSPVV 733

  Fly  1048 QT--MPILAPPRPATQVVPTEVYRS--SSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGL 1108
            .|  ||::|||.|.  |.|..:..|  |..:.:||....|.::||:::.:.|||:|..|..:...
Worm   734 PTVSMPLMAPPVPT--VAPMIMKESVGSHNMIVRFPTTMFDNRNGEIKQFAIIVSETTADESINR 796

  Fly  1109 EMPS------WLDVQSYSVWLPY-----------QAIDPYYPFENRSVEDFTIGTENCDNHKIGY 1156
            .:.|      |..||.:.||..|           |.:|... ||... ||.|......|.    .
Worm   797 WIESDNGTYTWQQVQRFDVWPSYVAKLQDIQKVKQDVDVSI-FEELG-EDETCLEVRADR----I 855

  Fly  1157 CNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTL----- 1216
            |||||:|.:.|||::|.||....|||:..| .:.|....|..|..:||...:|::..|.:
Worm   856 CNGPLRSASKYRVRIRLFTSPTLFTDSPPS-QVMTTGSATPAIPLLTVVAVLIVIAFVGIVGTIF 919

  Fly  1217 LFYKRRRNNCR------------------------------------------------------ 1227
            ||:..|....|
Worm   920 LFFWNRTKKARLAAAAFKNGPSKEKESQWEALKMMMAERAADCLAKLGLDATTPPPSSTTSSNSP 984

  Fly  1228 ----KTTKDSRANDNMSLPD----------------------------------SVI-----EQN 1249
                .|..|..:|.::..|:                                  :|:     .::
Worm   985 TSTSTTMTDCGSNPHLGAPNAGGHRRTRSLRERTGVEHRLERLSSGPVHRTPLYTVVTGANTNKS 1049

  Fly  1250 RPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFK 1314
            ||:.|::||:|.||||||||||||||::.:::||..|....::||.||||||||||..|||||.|
Worm  1050 RPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVK 1114

  Fly  1315 LQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGRE 1379
            |...::.||.||||||||||.:|.||||..||||.:|||.||:|.||....||:.||:|.||||:
Worm  1115 LSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRD 1179

  Fly  1380 KCDQYWP-NDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR----GSEQRILRHFHFTTWPDFGV 1439
            ||.|||| ::.|||.||||:|.|:.:..:.::|:.:..|.:    |...|.:||:|:..|||||.
Worm  1180 KCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGA 1244

  Fly  1440 PNPPQTLVRFVRAFRDRI--GAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYA 1502
            |:.|..:::|.|.||..:  .....|.:||||||||||||||::||:||..:..|.:|:||.|..
Worm  1245 PSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCE 1309

  Fly  1503 MRKERVWMVQTEQQYICIHQCLLAVLEGKE-NIVGPAREMHDNEGY--EGQQV 1552
            ||.||..|||.|||||.||.|:|.||:|.. :....:...|.|.|:  :||.:
Worm  1310 MRYERCQMVQNEQQYIFIHYCILQVLQGSSPSPTSTSTGAHHNAGFVQDGQMI 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020	13/73 (18%)
		FN3	511..574	CDD:238020	16/78 (21%)
		FN3	583..671	CDD:238020	23/90 (26%)
		fn3	683..753	CDD:278470	12/95 (13%)
		fn3	787..850	CDD:278470	15/67 (22%)
		fn3	866..935	CDD:278470	12/82 (15%)
		fn3	961..1043	CDD:278470	23/86 (27%)
		PTPc	1272..1525	CDD:214550	136/259 (53%)
		PTPc	1298..1525	CDD:238006	125/233 (54%)
dep-1	NP_001254192.1	FN3	640..736	CDD:238020	24/96 (25%)
		PTPc	1072..1333	CDD:214550	136/260 (52%)
		PTPc	1098..1333	CDD:238006	125/234 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158857
Domainoid	1	1.000	265	1.000	Domainoid score	I1007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	451	1.000	Inparanoid score	I899
Isobase	1	0.950	-	0	Normalized mean entropy	S5167
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm14294
orthoMCL	1	0.900	-	-		OOG6_106915
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X4185
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880