DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and K09F6.3

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001342012.1	Gene:	K09F6.3 / 173583	WormBaseID:	WBGene00019586	Length:	1391	Species:	Caenorhabditis elegans

Alignment Length:	1703	Identity:	302/1703 - (17%)
Similarity:	543/1703 - (31%)	Gaps:	610/1703 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 TVTITT-----------APDPPSNLSVQVRSGK-----NAIILWSPPTQGSYTAFKIKVLGLSEA 164
            |::.||           ..|.|...|:. |..|     |:|.|.:..|.|:...:.:.....:..
Worm    36 TISSTTDRMSPHRVDRQTTDDPLGFSIN-RMQKISRIVNSIYLTAELTAGTANTYDLIAEFFNFG 99

  Fly   165 SSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRN 229
            ..|||:...::....:..::|:.  :.:....||..|.:....:             :.::..|.
Worm   100 PDSYNKLQSIDMKELKSGLEEIV--SIHSELTYTDIDKRAEQRF-------------RHLIEIRK 149

  Fly   230 ETTLLVLW------QPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAY 288
            |...:...      |..|.:.:.|..|.:.:.....:              .|.|.|..:...|
Worm   150 EVEGVGSLEDIKDAQANYKSELETFKKTTFDTAGIEE--------------FQNAVKNFIGAAA- 199

  Fly   289 NISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATT 353
              .|:..|..|........|    .|||..|.      ..|...|.::...|:.||
Worm   200 --DVEKYSNLEKLTDVDIMY----ARPLIYTL------KTSIENLAKSYSSINSFD--------- 243

  Fly   354 RRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSG------KVTSWPATGDV---------TL 403
                            ||..|..|.:..:.|.|.|||      ..|:....|:.         .:
Worm   244 ----------------DFEKIRNPSEFVDPISKIVSGYKKYNASRTTIERDGNFAKGMQSNANNM 292

  Fly   404 RPLP------------VRNLRSIND-------DKTNTMIITWEADP----ASTQDEY-RIVYHEL 444
            :.|.            |:||:::.|       .|.....|....||    ...:|:: :.|.||:
Worm   293 KRLENVASVFEGLGSFVKNLQAVIDVRQTMHLPKYTVGFIDGTFDPKKVVTDLEDDWVQSVTHEM 357

  Fly   445 ETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPS----SPIIEDLK 505
                        |..| |:..|||..::..:::|......|.::..|...:.|    ||:...:.
Worm   358 ------------DLNR-TINLLLPIGDHVSAIEASFLSSSSKQSKFFTGFKSSETEVSPVDGSID 409

  Fly   506 SIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDL 570
            ||                              :.|.| |.|..:|..|.    |...:
Worm   410 SI------------------------------ISTSK-KVSECIIAPLT----YLESI------- 432

  Fly   571 RSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEY-SIRYRTDSEQQWVRLPSVRS 634
             .|.....||:   .....|::|:.....||:|.........|. ::...||.|:        :.
Worm   433 -KEVEILLQAI---ESLKKTVDTLVGTKELVNWVKTNDVVLKEVEALCSYTDEEK--------KD 485

  Fly   635 TEADITDMTKG----EKYTIQVNTV---SFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEW 692
            .|:.:....||    |.||..:.|:   |...::...::::||
Worm   486 FESSVPIKLKGLKSSENYTSLIKTLNQSSLFADAVFSEKLSTT---------------------- 528

  Fly   693 PKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIG----ELMP------GVQYKF 747
                |:..:|||        |.:|:.:...|.:.|.::....|:.    :|:|      ....|.
Worm   529 ----GQETAYIL--------GGLQSLDAFYNSATDHIAFFDCLLNVAYYDLIPLAIDTLNKVRKM 581

  Fly   748 DIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGD 812
            |:|....||                 |||                          .|::..|...
Worm   582 DVQPIRDGI-----------------DVV--------------------------NDLFNVSNQL 603

  Fly   813 AEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITD 877
            .|::.|.:..||.:..:..|.|....|:..|:.....||    |:.:|
Worm   604 DELKTKLRELNDPNFSIAETPLSNPSLHTTTIGLSVRGV----IRMKD----------------- 647

  Fly   878 TEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLR 942
             ||..|        :|||:....|: ::.|.|....:..|:            :|..|:....|:
Worm   648 -EIDHR--------SDFDVVIENAE-MVDQEMKNTGKKAIN------------MVEFGSRLKKLK 690

  Fly   943 SSSPLSASFTTNEAVPG--RVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDA 1005
            |.   ...:.:|..|.|  |:.|..|:....:.| |:.:|   :..||       ..::..|.||
Worm   691 SE---LEGWKSNITVGGAHRIRRSTPSLADYAHI-FQNAL---KVGGV-------DDDLKKLMDA 741

  Fly  1006 GMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRS 1070
             ::|||           |.|:....|::.|.
Worm   742 -VKDFE-----------KTGKDAATKVKLKE---------------------------------- 760

  Fly  1071 SSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDV-----QSYSVWLPYQAIDP 1130
                                     ::|..::.|:.||::.|:...     ||:|      |:|.
Worm   761 -------------------------VIASLNSLNSIGLQLSSFATPFTAIGQSFS------ALDA 794

  Fly  1131 YYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQ-- 1193
            ::                ..|.||.....|:.|.:....:.:...|.......:.:..:.|.:
Worm   795 FF----------------VSNGKIITTPAPIVSSSGASQEGQKSAGGSMTLQPSQTVSVTTTEEP 843

  Fly  1194 --DNTSLIVAITVPLTIILV---LLVTLLFYKRRR--------------------------NNCR 1227
              ::|:|::.|.:...|:||   ::..:.||||.:                          .|..
Worm   844 MDESTNLMIFIGIGCGIVLVSALIVAVVCFYKRNKIANDDMEQGTKIEKEKIARELAAQEAQNIE 908

  Fly  1228 KTTKDSRANDNMSLPDSVIEQNRPILIKNFAE-----HYRLMSADS-----DFRFSEEFEELKHV 1282
            ...|.....|..:..|  .|:.:...||..||     |.:.:..|.     |.| |...|:...:
Worm   909 AEKKKKEIKDLEAKVD--YEKQKGEKIKEEAEKEIQDHRKKVEDDKLPKFYDIR-SPTIEDATAL 970

  Fly  1283 GRDQPCT-------------------FADLPCNR---------PKNRFTNILPYDHSRFKLQPVD 1319
            ..|:..|                   .|:|..|.         .::|::::|....:|..   :|
Worm   971 EGDKGATNNGKLPLKAMYQFCKSILRIANLAPNNAIVESEKYSEQDRYSDVLCGMDNRIL---ID 1032

  Fly  1320 DDE------GSDYINANYVPGHNSPREFIVTQGPLHSTR-------------------------- 1352
            :|.      ...||||||:...|..| .|:||.|:..|.
Worm  1033 EDVCRRCYFKDQYINANYLELPNGNR-MILTQAPMSRTEHFKPEKDKKRKNLYSLSDEEEEISYL 1096

  Fly  1353 ----DDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP--NDTVPVFYGDIKVQILNDSH-YADW 1410
                |.|::...::.:..:.||....|:|.|||..|:|  .|....|: ::.|...|..| .||.
Worm  1097 VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFH-NVNVCTTNVQHPSADV 1160

  Fly  1411 VMTEFMLCR--GSEQR--ILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAG 1471
            |:...::..  |.:::  .::|:.:..|.:...|..|:.::...|..|:     .:.:|||||.|
Worm  1161 VLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN-----SKSLVVHCSNG 1220

  Fly  1472 VGRSGTFI----TLDRILQQINTSDYV--DIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVL-- 1528
            :|||..|:    ...::::.::|:..|  |...::..:|..|...:.|..|   :...::.||
Worm  1221 IGRSAAFVFAEFVYQKMIRSLDTTSTVNLDFLSLLTELRHSRPRAIHTPMQ---LAFSIMMVLDF 1282

  Fly  1529 ---------------EGKENIVGPAREMHDN---EGYEGQQVQ--LDENGDVVATIEGHLSHHDL 1573
                           |.:::.:...:.||.:   :|.:|:.|.  |||:|..:...:|....:..
Worm  1283 VMNNFPKGEMEAKYQEIRKSYLHARQMMHKDLEFDGSDGKTVDIALDEDGHGIPEKKGKKKTNKK 1347

  Fly  1574 QQAEAEAIDDENA 1586
            ...:|....||.:
Worm  1348 AAQQASVKKDEKS 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	17/85 (20%)
		fn3	220..304	CDD:278470	13/89 (15%)
		fn3	315..391	CDD:278470	17/81 (21%)
		FN3	405..494	CDD:238020	22/112 (20%)
		FN3	511..574	CDD:238020	7/62 (11%)
		FN3	583..671	CDD:238020	18/95 (19%)
		fn3	683..753	CDD:278470	14/79 (18%)
		fn3	787..850	CDD:278470	10/62 (16%)
		fn3	866..935	CDD:278470	11/68 (16%)
		fn3	961..1043	CDD:278470	17/81 (21%)
		PTPc	1272..1525	CDD:214550	68/329 (21%)
		PTPc	1298..1525	CDD:238006	61/275 (22%)
K09F6.3	NP_001342012.1	WSN	56..124	CDD:197734	13/70 (19%)
K09F6.3	NP_001342012.1	PTPc	992..1281	CDD:214550	65/301 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910