DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and egg-5

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_491316.1	Gene:	egg-5 / 172007	WormBaseID:	WBGene00020035	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	685	Identity:	147/685 - (21%)
Similarity:	254/685 - (37%)	Gaps:	158/685 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   939 SVLRSSSPLSASFTTNEAVPGRVE-RFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNIN-- 1000
            |.||.|..|....:......||.| ..|..|::.::.:|         |.|..:...|.|.:.
Worm   117 SKLRKSKALDCLVSEKPKDEGRSEDSGHGADIEMAKGHF---------NDVRMKVFAARTAMQVE 172

  Fly  1001 -----------NLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILA 1054
                       .:.:|.:::.:|..||.:      ...|.....|::.:|           .|..
Worm   173 PALVMKTRKALEMKNAVLENHQSPGAFSL------HAAYKIAASAESRVG-----------SITP 220

  Fly  1055 PPRPATQVVPTEVYRSS-----STIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMP--- 1111
            ..:..|:.....:.|||     .|.::.|...:.|...|:   ||.|....| :|....:.|
Worm   221 CNKKVTKEAMANLIRSSYDDTEITQELLFSSKFDSKWKGR---YTDIYMRRD-ENGKKPKRPVNG 281

  Fly  1112 -SWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFT 1175
             .|:        :|.::|          .|.|.|.:....||:|     .|||.....:.:|..:
Worm   282 QGWV--------MPLKSI----------CEKFGINSTFFTNHRI-----DLKSARDQVLLMRLLS 323

  Fly  1176 GADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMS 1240
                             .|.||..::...|..:....|...|..:...:..:|..:..:||
Worm   324 -----------------HDQTSTWISDIHPEAVKNETLAEYLLRELDASTMQKRVQAFKAN---- 367

  Fly  1241 LPDSVIEQNRPILIKNFAEHY----RLMSADSDFRF--------SEEFEELKHVGRDQPCTFADL 1293
               .:.:::|..:...|..:.    |:..|....::        ...||.|::.....|.|.:..
Worm   368 ---VLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVNHIPFTHSAS 429

  Fly  1294 PCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRM 1358
            ..|:.|.|...:...|.:|..||........|:|:||.:.|.....|||:||.|:.:|.||||||
Worm   430 DNNQEKCRNPRVHCRDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRM 494

  Fly  1359 CWESNSRAIVMLTRCFEKGREKCDQYWPND------TVPVFYGDIKVQILNDSHYAD--WVMTEF 1415
            .|:.....|||||.  .|..|:|:.|||..      |||   |.::::........|  :.:|..
Worm   495 VWQEEVPYIVMLTS--RKEPERCEYYWPKSPSDPAVTVP---GGLRIENFGVYQAPDPLFRVTHL 554

  Fly  1416 MLC-RGSEQRILRHFHFTTWPDFGVPN------PPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVG 1473
            .|. ...|:|.:.|:.       |..|      .|..::|.:|       ...:|:|:|...||.
Worm   555 RLIGPDREERHVEHWQ-------GDVNNSSNMYSPLNILRLLR-------NASKPVVIHDHLGVS 605

  Fly  1474 RSGTFITLD-RILQQINTSDY-VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVG 1536
            |:...:..: .|...:....| ..:...|..:|:.|.:.::|..|||.:|:.:....   .:::|
Worm   606 RAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF---RDVIG 667

  Fly  1537 PAREMH-DNEGY---EGQQVQLDENGDVVATIEGH 1567
            .|:|:. |.|.:   ..:::.||   |:.|.|.|:
Worm   668 SAKELDVDYERWLQERSERMFLD---DLAAPIPGY 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470	15/95 (16%)
		PTPc	1272..1525	CDD:214550	73/277 (26%)
		PTPc	1298..1525	CDD:238006	67/243 (28%)
egg-5	NP_491316.1	PTPc	407..660	CDD:214550	73/271 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910