DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprg

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_599183.2	Gene:	Ptprg / 171357	RGDID:	620774	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	1200	Identity:	289/1200 - (24%)
Similarity:	450/1200 - (37%)	Gaps:	389/1200 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 IVYHELETFNGDTSTLTTDRTRFTLESLLP---GRNY----SLSVQAVSKKMESNETSIFVVTRP 496
            :|:||.|||          ...|.|..|||   |..|    ||:....|:.:|      ::|.|.
  Rat   224 VVHHEKETF----------LDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVE------WIVFRR 272

  Fly   497 SSPI----IEDLKSIRMGLNISWKSDVNSKQEQY--EVLYSRNGTSDLRTQKTKESRLVIKN-LQ 554
            ..||    :|...||           ..::|:.:  .|.|.||   :.|.|:....|:|.|: ::
  Rat   273 PVPISYHQLEAFYSI-----------FTTEQQDHVKSVEYLRN---NFRPQQALNDRVVSKSAVR 323

  Fly   555 PGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYR 619
            ....::|..| :.:.|.:|.    ..|..:||.:|.::.:...::.|.||.||
  Rat   324 DAWNHDLADF-LDNPLGTEA----SKVCSSPPIHMKVQPLNQTALQVSWSQPE------------ 371

  Fly   620 TDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVD 684
                                                              |:...|:.|.:
  Rat   372 --------------------------------------------------TIYHPPIMNYM---- 382

  Fly   685 SRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDI 749
               |:..|.|.|...|....|                     |....::..|..:.|...|.|.:
  Rat   383 ---ISYSWTKNEDEKEKTFTK---------------------DSDKDLKATISHISPDSLYLFRV 423

  Fly   750 QTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAE 814
            |..   ..:.:.|.:.:|| |.|     ||..:..:...|..:..||...:|..|:...|.|.
  Rat   424 QAV---CRNDMRSDFSQTM-LFQ-----ANTTRIFQGTRIVKTGVPTASPASSADMAPISSGS-- 477

  Fly   815 IRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTE 879
                                        :.||.||                         |..:.
  Rat   478 ----------------------------STWTSSG-------------------------IPFSF 489

  Fly   880 ISLRWDL-PKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTV-VVRSGTESSVLR 942
            :|:...: |....:...:|.:....|||........|:        ::..|| ..|..|.|:..:
  Rat   490 VSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGIS--------SFPSTVWPTRLPTASAASK 546

  Fly   943 SSS-PLSASFTTNEAV--PGRVERFHPT-DVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLT 1003
            .:. |:.|   |.||:  ||......|| |.:.:|...:.....||
  Rat   547 QAGRPVLA---TTEALASPGPDGDSAPTKDGEGAEEGEKEEKSESE------------------- 589

  Fly  1004 DAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRP-------ATQ 1061
             .|.::.|.||        |..|    |.:...|.....|.:  ||.|...|..|       ..|
  Rat   590 -DGEREQEEEE--------KDSE----KKEKSEATHTAAESD--QTAPAPTPSSPHRTAQEGGHQ 639

  Fly  1062 VVPTEVYRSSSTIQIRFRKNYFSDQNGQV--RMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLP 1124
            .:|......|:.:         :||.|.|  .:.|::   |.|     .::|.....:.||
  Rat   640 TIPGHRQDHSAPV---------TDQPGHVDPGLDTLV---DTA-----TQVPPTATEEHYS---- 683

  Fly  1125 YQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPI 1189
              ..||..| |..|.:                   |:..|             |:|::.:....:
  Rat   684 --GSDPKRP-EMPSKK-------------------PISRG-------------DRFSEDSKFITV 713

  Fly  1190 QTDQDNTSLIVA--------ITVPLTII-------LVLLVTLLFYKRRRNNCR------------ 1227
            ...:.|||.:::        ..:||.::       ||||:.:|.|.|..|..:
  Rat   714 NPAEKNTSGMISRPSPGRMEWIIPLIVVSALTFVCLVLLIAVLVYWRGCNKIKSKGFPRRSREVP 778

  Fly  1228 ----KTTKDSRA--------NDNMSLPDSVIEQNRPIL----------IKNFAEHYRLMSADSDF 1270
                :..|.||.        .::.|.|..|..::.||:          :|.|.:|...:.::|..
  Rat   779 SSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFGKHIGELYSNSQH 843

  Fly  1271 RFSEEFEELKHVGRDQPCT--FADLPCNRPKNRFTNILPYDHSRFKLQPV--DDDEGSDYINANY 1331
            .||.:|||::....|...|  .::.|.|:.|||:.|||.|||||.||:|:  .|.:.||||||||
  Rat   844 GFSGDFEEVQRCTADMNITAEHSNHPDNKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANY 908

  Fly  1332 VPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGD 1396
            |.|:|..:.:|.|||||.||.:|||||.||.|:..|:|:|...||||.|||||||.:.... ||:
  Rat   909 VDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNLVEKGRRKCDQYWPTENTEE-YGN 972

  Fly  1397 IKVQILNDSHYADWVMTEFML--------------CRGSEQRILRHFHFTTWPDFGVPNPPQTLV 1447
            |.|.:.:...:|.:.:..|.:              .|.:|:.::: :|:|.|||.|||.....::
  Rat   973 IIVTLKSTEVHACYTVRRFSVRNTKVKKGQKGNPKGRQNERTVIQ-YHYTQWPDMGVPEYALPVL 1036

  Fly  1448 RFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQ 1512
            .|||........:..|::|||||||||:||:|.:|.:||||.....|::.|.:..:|.:|.::||
  Rat  1037 TFVRRSSAARMPDMGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQ 1101

  Fly  1513 TEQQYICIHQCLLAVLEGKENIVGPAREMH 1542
            ||:|||.||..||..:.|||..|. :.::|
  Rat  1102 TEEQYIFIHDALLEAILGKETEVS-SSQLH 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020	17/61 (28%)
		FN3	511..574	CDD:238020	13/65 (20%)
		FN3	583..671	CDD:238020	8/87 (9%)
		fn3	683..753	CDD:278470	12/69 (17%)
		fn3	787..850	CDD:278470	10/62 (16%)
		fn3	866..935	CDD:278470	11/70 (16%)
		fn3	961..1043	CDD:278470	14/82 (17%)
		PTPc	1272..1525	CDD:214550	115/270 (43%)
		PTPc	1298..1525	CDD:238006	106/242 (44%)
Ptprg	NP_599183.2	alpha_CARP_receptor_like	67..319	CDD:239396	33/124 (27%)
		FN3	348..438	CDD:238020	24/182 (13%)
		R-PTPc-G-1	845..1118	CDD:350505	117/274 (43%)
		R-PTP-G-2	1202..1406	CDD:350508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910