DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and DCC

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens


Alignment Length:1382 Identity:270/1382 - (19%)
Similarity:451/1382 - (32%) Gaps:512/1382 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 YQVQAYTIYDGKESVAYTSRNFT-----------TKPNTPGKF--IVWFRNE--------TTLLV 235
            |...::|...|:|.:...|:.::           ...:..|.:  :|.::||        |.|:.
Human   266 YPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTV
LVP 330

  Fly   236 LWQPPYPAGIYTHYKVSIE-----------------------PPD-------ANDSVLYVEKEGE 270
            .|...:|:.:|.:..:.||                       |.|       :|..:|.|.|..|
Human   331 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDE 395

  Fly   271 ---------PPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFIT 326
                     ..|.||.:.:.:||..|              :|:::   .:|..|.:|.  ...::
Human   396 GFYQCVAENEAGNAQTSAQLIVPKPA--------------IPSSS---VLPSAPRDVV--PVLVS 441

  Fly   327 SNSFRVLWEAP---KG-ISEF--------DKYQVSVATTR---RQSTVPRSNEPVAFFDFRDIA- 375
            |...|:.|..|   || |..|        |..:.::.||:   .|.|| .:.:|.|.:.||.:| 
Human   442 SRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTV-GNLKPEAMYTFRVVAY 505

  Fly   376 ---EPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQ--- 434
               .||::...|      ||.:.|   ::.: |.||.||::::...| :::|||| .||...   
Human   506 NEWGPGESSQPI------KVATQP---ELQV-PGPVENLQAVSTSPT-SILITWE-PPAYANGPV 558

  Fly   435 DEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSP 499
            ..||:...|:.|  |....:..|...:.||.|.....|||...|                     
Human   559 QGYRLFCTEVST--GKEQNIEVDGLSYKLEGLKKFTEYSLRFLA--------------------- 600

  Fly   500 IIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVF 564
                                          |:|.|                    ||        
Human   601 ------------------------------YNRYG--------------------PG-------- 607

  Fly   565 AVSHD------LRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGE----FTEYSIRYR 619
             ||.|      |...|.|        ||:|:::|.|.|.|:.|.|.||.||.    .|.|.||:|
Human   608 -VSTDDITVVTLSDVPSA--------PPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHR 663

  Fly   620 TDSEQQWVRLPSVRSTEAD-----ITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNI 679
                 :..|...:.:.|.:     .|.:.||.:|:.||:.::          ||.|.||:     
Human   664 -----KTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMT----------VNGTGPPS----- 708

  Fly   680 IQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRV------LIGE 738
                                     .|:.::.|    ..::.|::..|..|::.|      :|..
Human   709 -------------------------NWYTAETP----ENDLDESQVPDQPSSLHVRPQTNCIIMS 744

  Fly   739 LMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKF 803
            ..|.:..  :|....|.|..|:.|.|..|: .:.|.....:.|:.:......:|......:....
Human   745 WTPPLNP--NIVVRGYIIGYGVGSPYAETV-RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806

  Fly   804 DIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPE-PI 867
            .:|       |......:.:.||         |...|.:        :...|....|...|. |.
Human   807 PLY-------ESATTRSITDPTD---------PVDYYPL--------LDDFPTSVPDLSTPMLPP 847

  Fly   868 TQLHATNITDTEISLRW---DLPK----GEYNDFDIAYLTADNLLAQ---NMTTRNEITISDLRP 922
            ..:.|..:|...:.:.|   .:||    .|...:.:.:.|:.:..|:   ..||....|.:.|:|
Human   848 VGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKP 912

  Fly   923 HRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDV-------QPSEINFEWSL 980
            :..|.|:|:|.....|    |:..::|..||.||.|...    |.|:       :|..:...|. 
Human   913 NTMYEFSVMVTKNRRS----STWSMTAHATTYEAAPTSA----PKDLTVITREGKPRAVIVSWQ- 968

  Fly   981 PSSEANGVIRQFSIAYTNINN--LTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPE 1043
            |..||||.|..:.:.||...|  :.|..|:....:.....|.:|.....|.|:|||:.:.|.|| 
Human   969 PPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGP- 1032

  Fly  1044 REYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGL 1108
                     |:.|                 |..|..|....|:          :|.|..::..| 
Human  1033 ---------LSDP-----------------ILFRTLKVEHPDK----------MANDQGRHGDG- 1060

  Fly  1109 EMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRA 1173
                                 .|:|.:...::..|:     :...||..:.|..|          
Human  1061 ---------------------GYWPVDTNLIDRSTL-----NEPPIGQMHPPHGS---------- 1089

  Fly  1174 FTGADKFTDTAYSFPIQTDQDNTSLIVAITVP---LTIILVLLVTLLFYKRRRNNCRK------- 1228
                            .|.|.|::|:|.|.|.   :|:::|::|.::..:|.....||       
Human  1090 ----------------VTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSA 1138

  Fly  1229 -----TTKDSRAND-----------NMSLP--------DSVIEQNRPILIKNFAEHYRLMSADSD 1269
                 :.||.|..|           |:..|        ||.|:..:.:...:.::....:.:.|.
Human  1139 GKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKST 1203

  Fly  1270 FRFSEEFEEL---------KHVGRDQPCTFADLPCNRPKN----------------RFTNILP-- 1307
            ....::.||.         ....|..|.....:|.:...|                ::..|||  
Human  1204 SHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSP 1268

  Fly  1308 ---YDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL-------------HSTRDDFW 1356
               |.|.:|.|:||      .:...:...|..:.|...|::||.             ||:.:   
Human  1269 TCGYPHPQFTLRPV------PFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSE--- 1324

  Fly  1357 RMCWESNSRAIVMLTRC 1373
                |:.||.|.  |.|
Human  1325 ----EAPSRTIP--TAC 1335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 3/12 (25%)
fn3 220..304 CDD:278470 24/132 (18%)
fn3 315..391 CDD:278470 24/94 (26%)
FN3 405..494 CDD:238020 25/91 (27%)
FN3 511..574 CDD:238020 9/68 (13%)
FN3 583..671 CDD:238020 28/96 (29%)
fn3 683..753 CDD:278470 9/75 (12%)
fn3 787..850 CDD:278470 7/62 (11%)
fn3 866..935 CDD:278470 18/78 (23%)
fn3 961..1043 CDD:278470 24/90 (27%)
PTPc 1272..1525 CDD:214550 28/145 (19%)
PTPc 1298..1525 CDD:238006 23/110 (21%)
DCCNP_005206.2 Ig1_Neogenin 41..136 CDD:143199
IG_like 46..136 CDD:214653
IG_like 147..224 CDD:214653
IGc2 153..219 CDD:197706
I-set 241..327 CDD:254352 9/60 (15%)
Ig 244..327 CDD:299845 9/60 (15%)
I-set 331..417 CDD:254352 15/85 (18%)
Ig 347..417 CDD:299845 12/69 (17%)
FN3 429..521 CDD:238020 27/100 (27%)
FN3 528..617 CDD:238020 33/172 (19%)
FN3 625..715 CDD:238020 32/134 (24%)
FN3 726..805 CDD:214495 15/81 (19%)
FN3 846..939 CDD:238020 21/96 (22%)
FN3 946..1041 CDD:238020 28/126 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152 5/25 (20%)
Neogenin_C 1148..1445 CDD:284094 36/203 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222 7/56 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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