DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptprsa

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_021325154.1	Gene:	ptprsa / 140820	ZFINID:	ZDB-GENE-020107-3	Length:	1945	Species:	Danio rerio

Alignment Length:	1768	Identity:	401/1768 - (22%)
Similarity:	636/1768 - (35%)	Gaps:	535/1768 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AISIPNNPGLDDGASYR--------LDYSPPFGY------------PEPNTTIASREIGDEIQFS 90
            |:.|.|....|.| .|.        :.||.|...            |..:....|:||
Zfish   198 ALQIENTEETDQG-KYECVASNVEGVRYSSPANLYVRELREVRRVPPRFSILPTSQEI------- 254

  Fly    91 RALPGTKYNFWLYYTN--FTHHDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTA 153
              :||...|.......  ..:..|:..:..:|...:.|        .|:|.:.|.|.....:||.
Zfish   255 --MPGGSVNITCVAVGSPMPYVKWMLNSEDLTPEDEMP--------VGRNVLELNSVRESANYTC 309

  Fly   154 FKIKVLGLSEASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPN 218
            ..:..||:.|..:             |.:||.|                              |.
Zfish   310 VAMSSLGIIETVA-------------QITVKSL------------------------------PK 331

  Fly   219 TPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLV 283
            .||..:|.....|::.:.|....|..: :||.:.           |..|..|
Zfish   332 PPGTPVVTETTATSITITWDSGNPEPV-SHYIIQ-----------YRAKSPE------------- 371

  Fly   284 PGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQV 348
                                  :::.||           |.||:..:.:     .|:|....|::
Zfish   372 ----------------------SKFETV-----------DSITTTRYSI-----GGLSPNTDYEI 398

  Fly   349 SVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNL-- 411
            .|:........|.| |||.       |..|:              ..||:        |.||:
Zfish   399 RVSAFNTIGQGPPS-EPVE-------ARTGE--------------QAPAS--------PPRNIQA 433

  Fly   412 RSINDDKTNTMIITWEA--DPASTQDEYRIVYHELETF--------NGDTSTLTTDRTRFTLESL 466
            |.|:.   ||:::.|:.  :|......||:.|....|.        |...|.||      |::||
Zfish   434 RIISQ---NTVLVRWDEPDEPNGQIKGYRVYYTMDPTLPMSMWQIHNVQDSVLT------TIQSL 489

  Fly   467 LPGRNYSLSVQAVSKKME---SNETSIFVVTR-PSSPIIEDLKSIR-MGLNISW-----KSDVNS 521
            :....|::.|.|.:...:   |:...:.|:.. |..|....:..:. .|:.::|     |..:.|
Zfish   490 VTSETYTIRVLAFTSVGDGPFSDPIHVKVLQGVPGQPTNFQVGEVSDTGVELTWEPAFEKEGIIS 554

  Fly   522 KQEQYEVLYSRNGTSDLRTQK-TKESRLVIKNLQPGAGYELKVFAVS--------HDL-----RS 572
                ||:.|.......|..:| ...|..|:..|:|...|...:.|||        :||     ::
Zfish   555 ----YELHYKEGKDGPLGKKKFAPTSSFVVDGLRPNTEYFFSLAAVSSKGIGAFTNDLAQTTSQA 615

  Fly   573 EPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPP----ESGEFTEYSIRYRTDSEQQWVRLPSVR 633
            :|.|        ||:::...:..|..::|.|.||    ::||...|.:||........|....|.
Zfish   616 KPSA--------PPQDIKCSSSSSTVLMVSWRPPPAESQNGELAGYIVRYAVVGAGAEVSTEHVE 672

  Fly   634 STEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGR 698
            :..:|...:.:.||:|:...||:          .:|:|...|.|..:......::
Zfish   673 APTSDQILLQRLEKWTMYRVTVA----------ASTSVGSGPESEPLLCRTDEDV---------- 717

  Fly   699 VESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSL 763
                     |...|.||:.:.::.       :.::|:...|:||.|         :|.:.|....
Zfish   718 ---------PGAPPRRVEVEVLNS-------TAIKVMWRSLLPGKQ---------HGQIRGYQVH 757

  Fly   764 YPRT-------MPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKL 821
            |.|.       :|||: ||::|:.:.|.: ||..               |...:|
Zfish   758 YVRVENGESRGLPLIK-DVMLADAQWEMD-DTAE---------------YEMVIG---------- 795

  Fly   822 ANDTDRKVTFTGLVPGRLYNITV--WTVSG-GVASLP--IQRQDRLYPEPITQLHATNITDTEIS 881
                       ||.|...|:|||  :|..| |..|.|  :..:..:...|...:: .|...|.|
Zfish   796 -----------GLQPDTTYSITVAAYTTKGDGARSKPKLVLTKGAVPGPPFLSVN-QNSESTAI- 847

  Fly   882 LRWDLP------------KGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRS 934
            :||..|            :.::...|:..|.......|.:    |.:||::  ||..|:...|.:
Zfish   848 IRWQPPDYVAPGLEVQGYRLQFGRKDVNPLATLEFGPQEL----EYSISNI--HRGATYIFKVSA 906

  Fly   935 GTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEI-----NFEWSLP-SSEANGVIRQFS 993
                   :|.|......|....||..|.|.:|...:.|.|     .|.|..| .:|.||.|.:::
Zfish   907 -------KSKSGFGEEATQELRVPEEVPRGYPQITEGSNITCCSVQFSWLPPVLAERNGAITEYT 964

  Fly   994 IAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIG---FGPEREYRQTMPILAP 1055
            ::|.....::........::|...::.:|:|...|..||:|.|::|   :.|..:||........
Zfish   965 LSYQEAGTISGPKELRLPADENSYILNSLRPNAVYDVKIRAHTSVGPGPYSPPIQYRTVAYEADV 1029

  Fly  1056 PRPATQVVPT---------------------EVYRSSSTIQIRFRKNYF---------------- 1083
            ||..|..:.|                     |.:|..|.|..|..|...
Zfish  1030 PRNFTVKLVTKTTVLLSWKFYDSRFPYKCTIEYHRQKSDIDARMTKTLITNLRPNTTYEFRISCQ 1094

  Fly  1084 -SDQNG-------------QVR-----------------------------MYTIIVAEDDAKNA 1105
             |...|             |:|                             :|.::|   ..|..
Zfish  1095 DSSDGGPKHKLVARTAPHIQIRKPELDLKRESESTLTIVFPPLETKDLIKAIYVVVV---PLKKG 1156

  Fly  1106 SG----LEMPSWLDVQSY-----------SVWLPYQAIDPYYPFENRSVE------DFTIGTENC 1149
            .|    ::.|..||::..           ......:.:|...|:...|.:      .||:|.:..
Zfish  1157 KGPMRHIKSPDELDLEELLGERRLGLHHSGTTRQLKQVDGKRPYIAASFKPSSMPPSFTLGNQMM 1221

  Fly  1150 DNHKIGYCNGPLKSGTTYRVKVRA---FTGADKFTDTAYSFPI----------QTDQDNTSLIVA 1201
            ..   .:.|..|..|..|.:.:.|   .||...|..:.|:.||          ::..|....:|.
Zfish  1222 YG---SFENRALDRGQEYVLFILAELNTTGVKAFVSSPYTDPIMAPDLDPQPLESGGDGLIWVVG 1283

  Fly  1202 ITVPLTIILVLLVTLLFYKRR------------RNNCRKTTKDSRAND----------NMSLPDS 1244
            ..:.:..|:.:::.:|.||..            |..|.....|...:.          |...|||
Zfish  1284 PVLAVVFIICIVIAILLYKNSKPDSSKRKESEPRTKCLLNNADITPHHPTDPVEMRRINFQTPDS 1348

  Fly  1245 VIE--------------QNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPC 1295
            .:.              .:.||.|...|||..|:.|:.:.:.|:|:|.: ..|:......::|..
Zfish  1349 GLSSPVSEAGFDYESMMNHPPIPISELAEHTELLKANDNLKLSQEYESI-DPGQQFTWEHSNLEV 1412

  Fly  1296 NRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCW 1360
            |:||||:.|::.|||||..|.|::...||||||:||:.|:.....:|.|||||..|..|||||.|
Zfish  1413 NKPKNRYANVIAYDHSRVILAPIEGITGSDYINSNYIDGYRKQNAYIATQGPLPETFGDFWRMVW 1477

  Fly  1361 ESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQ 1423
            |..:..:||:||..||.|.|||||||:..... ||.|:|.:|:....|.:.:..|.|.:  .||:
Zfish  1478 EQRAATVVMMTRLEEKSRIKCDQYWPSRGTET-YGMIQVTLLDTIELATFCVRTFSLHKNGSSEK 1541

  Fly  1424 RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQI 1488
            |.:|.|.||.|||.|||..|...:.|:|..:.....:..||:.||||||||:|.||.:|.:|::|
Zfish  1542 REVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIIAHCSAGVGRTGCFIVIDAMLERI 1606

  Fly  1489 NTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEGKENIVGPAREMHDNEGYEGQQV 1552
            .....|||:|.|..||.:|.:|||||.||..||..|| ||..|...:.  ||.:.   .|..:..
Zfish  1607 KHEKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAVACGNTEVA--ARSLF---SYIQKLA 1666

  Fly  1553 QLDENGDVVATIE 1565
            |: |.|:.|:.:|
Zfish  1667 QV-EAGEHVSGME 1678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	14/80 (18%)
		fn3	220..304	CDD:278470	11/83 (13%)
		fn3	315..391	CDD:278470	14/75 (19%)
		FN3	405..494	CDD:238020	25/103 (24%)
		FN3	511..574	CDD:238020	18/81 (22%)
		FN3	583..671	CDD:238020	21/91 (23%)
		fn3	683..753	CDD:278470	9/69 (13%)
		fn3	787..850	CDD:278470	13/65 (20%)
		fn3	866..935	CDD:278470	17/80 (21%)
		fn3	961..1043	CDD:278470	22/90 (24%)
		PTPc	1272..1525	CDD:214550	112/254 (44%)
		PTPc	1298..1525	CDD:238006	106/228 (46%)
ptprsa	XP_021325154.1	I-set	31..122	CDD:254352
		Ig2_RPTP_IIa_LAR_like	150..233	CDD:319301	9/35 (26%)
		Ig3_RPTP_IIa_LAR_like	257..325	CDD:143216	15/88 (17%)
		FN3	330..419	CDD:238020	27/159 (17%)
		FN3	426..518	CDD:238020	24/108 (22%)
		FN3	523..612	CDD:238020	21/92 (23%)
		FN3	620..713	CDD:238020	24/102 (24%)
		fn3	721..819	CDD:306538	33/151 (22%)
		FN3	831..919	CDD:238020	20/102 (20%)
		fn3	931..1015	CDD:306538	20/83 (24%)
		FN3	1028..1101	CDD:238020	11/72 (15%)
		PTPc	1415..1644	CDD:238006	107/229 (47%)
		PTPc	1676..1935	CDD:214550	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940