DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptprfa

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_021332435.1	Gene:	ptprfa / 140819	ZFINID:	ZDB-GENE-020107-2	Length:	1918	Species:	Danio rerio

Alignment Length:	1595	Identity:	385/1595 - (24%)
Similarity:	609/1595 - (38%)	Gaps:	406/1595 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 TWTVTITTAPDPPSNLSVQVRSGKNAIILWSP--PTQGSYTAFKIKVLGLSEASSSYNRTFQVND 176
            |..:|:...|.||::|.|...:..:..:.|..  |...||...:.:              .:::|
Zfish   320 TAQITVKALPRPPASLIVTETTATSVTLTWDSGNPEPVSYYVIQYR--------------SKISD 370

  Fly   177 NTFQ---------HSVKELTPGATYQVQAYTIYD---GKESVAYTSRNFTTKPNTPG-KFIVWFR 228
            |.||         :|:..|:|.:.|:.:...:.:   |..|....:|.....|::|. :......
Zfish   371 NGFQEVDGVASTRYSIGGLSPYSEYEFRVMAVNNIGRGPPSGMVETRTSEQAPSSPPLRVQARML 435

  Fly   229 NETTLLVLWQPP-YPAG-------IYT---HYKVSI-EPPDANDSVLYVEKEGEPPGPAQAAFKG 281
            :.||:||.|:|| .|.|       .||   |:.:|. :..:..||.|             ....|
Zfish   436 SATTMLVQWEPPEEPNGQIRGYRVYYTSDLHFPLSTWQKHNTEDSSL-------------TTISG 487

  Fly   282 LVPGRAYNISVQTMSEDEISLPT-TAQYRT---VPLRPLNVTFDRDFITSNSFRVLWEAPKGISE 342
            |||...|.:.|...:......|: ..|.:|   ||.:|.....:.:..|......||.....|::
Zfish   488 LVPDITYGLRVLAFTSVGDGPPSDILQVKTQQGVPAQPTGFEAEAELDTRIMLSWLWPVQDQITK 552

  Fly   343 FDKYQVSVATTRRQSTV--PR------SNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVT-SWPAT 398
            ::.......:..:...:  |.      |.:|...:.|...|.......|..:.:..:.. |.|:.
Zfish   553 YELTYWEADSDNKHHVIFDPAGSYAIDSLKPDTLYKFSLAARSEMGLGVYTQPIEARTAQSAPSA 617

  Fly   399 GDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQD----EYRIVY----------HELETFNG 449
                  |....:|.|::   ::::.::|.|.||:::.    .|.:.|          ||::....
Zfish   618 ------PPQEVHLISLS---SSSIKVSWVAPPAASRHGSIVRYSLAYQAVSGEDQERHEVKDIPA 673

  Fly   450 DTSTLTTDRTRFTLESLLPGRNYSLSVQA---VSKKMESNETSIFVVTR-PSSP----IIEDLKS 506
            |.|:       :.||.|.....|::.|:|   |....||..|.|..... |.:|    .::::.|
Zfish   674 DVSS-------YVLEGLEKWTEYTVWVKAHTDVGPGPESGSTRIRTQEDVPGAPPRRVEVDNINS 731

  Fly   507 IRMGLNISWKSDVNSKQ----EQYEVLYSR--NGTS-------DLRTQKTKESRLVIKNLQPGAG 558
              ..|.:|||..:..||    ..|:|:|||  ||..       |:...:.:|:  ||..|.|...
Zfish   732 --TALRVSWKPPLQQKQHGHIRGYQVVYSRLENGEPRGQPIILDVALPEAQEA--VISGLLPETT 792

  Fly   559 YELKVFAVS---HDLRSEPHAY-FQAVYPNPPRNMTIETVRSNSVLVHWSPPES--GEFTEYSIR 617
            |.:.|.|.:   ...||:.... .....|..| .|.|.|...|:.|:.|.||:.  ||...|.:|
Zfish   793 YSVTVAAYTTKGDGARSKAKVVTTTGAVPGKP-TMIISTTIGNTALIQWQPPKEMVGELMGYRLR 856

  Fly   618 YRTDSEQQWVRLPSVRSTE--ADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNII 680
            |:.:.|..:. :...|.|:  ..:|.:.||
Zfish   857 YKREEEDIYT-VRDFRRTDDHFTVTGLHKG----------------------------------- 885

  Fly   681 QLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQY 745
                               .:||.|         :..||.:.|                  |.:|
Zfish   886 -------------------ATYIFK---------LCAKNRAGN------------------GEEY 904

  Fly   746 KFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSL 810
            ..:|.|.     ..:.|.||:.:.::.....           |..|::.|.|.......|.|:.:
Zfish   905 SKEISTP-----EDVPSSYPQNLKVVGLTTT-----------TTKLAWDPPPLPERNGKIVRYVV 953

  Fly   811 GDAEIRDKEKLANDT-DRKVTFTGLVPGRLYNITV--WTVSGG---VASLPIQRQDRLYPEPITQ 869
            ...:|...:...|.| |.::|..||.|...|:|.|  :|..||   ..|:..:......||....
Zfish   954 VYRDINSHQNQTNGTADTEMTIQGLKPDTTYDIRVRAFTGKGGGPISPSIQSRTMSTSMPEFTKN 1018

  Fly   870 LHATNITDTEISLRWDLPKGEYND---FDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVV 931
            .....:..|.:.|.|::|: .|..   |.|.| ...::..|....|..||  .|:|..:|:|.::
Zfish  1019 FGVKAVMKTSVLLTWEVPE-TYKSQVPFKILY-NQQSVEVQGDLKRKLIT--RLQPDTDYSFVLM 1079

  Fly   932 VRSGTESSVLRSSSPLSAS--FTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSI 994
            .|..:...:.:..|..:|.  |||..|    .::..|.:.....|    :||....:.::|.|.|
Zfish  1080 SRGNSAGGLQQQVSIRTAPDLFTTKPA----HQKLDPEEGGKLAI----TLPEVHNSALVRWFYI 1136

  Fly   995 AYTNINNLT---DAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPP 1056
            ....:...|   ....:|.:.:|..|..::              .|:    .|..|||...|.|
Zfish  1137 VVVPVTPSTLRHWENPEDIDLDELMGNNRD--------------AAV----RRRRRQTQDFLRP- 1182

  Fly  1057 RPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSV 1121
                                     |.                     |:.||.
Zfish  1183 -------------------------YI---------------------AAKLES----------- 1190

  Fly  1122 WLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKV-RAFTGADK-FTDTA 1184
             ||               |.|.:|.|...::   |.|.||.....||..: .|....|. ||.:.
Zfish  1191 -LP---------------ERFVLGDEKTYSN---YYNKPLPGQQQYRTFILAALKDRDSTFTVSP 1236

  Fly  1185 YSFPIQTD---------QDNTSLIV---AITVPLTIILVLLVTLLFYKRRRNNCRKTTKD----- 1232
            :|.|:...         :|...|.|   .:.|.|.||:|:.:.|...|:.|.....:.||
Zfish  1237 FSEPMMVKLHSGMSRHVEDPEMLWVMGPVLAVVLIIIIVIAILLFKSKQERKRTSPSAKDEHSAG 1301

  Fly  1233 ------SRANDNMSL----------------PDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEE 1275
                  :.::|.:.:                ..|.:.::.|:.:...|:|...:.|:...|||:|
Zfish  1302 VKDHLLAHSSDPVEMRRLNYQTQGSSAFNCPSTSRMREHPPVSVCALADHIERLRANDSLRFSQE 1366

  Fly  1276 FEELKHVGRDQPCTF--ADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSP 1338
            :|.   |...|..|:  ::|..|:||||:.|::.|||||..|.|||...||||||.||:.|:...
Zfish  1367 YES---VDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVVLTPVDGVPGSDYINGNYIDGYRKQ 1428

  Fly  1339 REFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILN 1403
            ..:|.|||||..|..|||||.||..:..|||:||..||.|.|||||||:..... ||.|:|.:|:
Zfish  1429 NAYIATQGPLPETLSDFWRMVWEQRTSTIVMMTRLEEKSRVKCDQYWPSRGTET-YGMIQVSMLD 1492

  Fly  1404 DSHYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVV 1466
            ....|.:.:..|.|.:  .||:|.:|.|.|..|||.|||..|..::.|:|..:.....:..|:||
Zfish  1493 TVELATYSVRTFALYKNGSSEKREVRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPPDAGPMVV 1557

  Fly  1467 HCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEG 1530
            ||||||||:|.||.:|.:|:::.....|||:|.|..||.:|.:|||||.|||.||:.|| |...|
Zfish  1558 HCSAGVGRTGCFIVIDAMLERMKHEKSVDIYGHVTCMRSQRNYMVQTEDQYIFIHEALLEAATCG 1622

  Fly  1531 KENIVGPAREMHDNEGYEGQQVQLDENGDVVATIE 1565
            ...:  |||.::.:.    |::.....||.|..:|
Zfish  1623 NTEV--PARSLYTHI----QKLTQAPPGDTVTAME 1651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	17/94 (18%)
		fn3	220..304	CDD:278470	23/96 (24%)
		fn3	315..391	CDD:278470	11/83 (13%)
		FN3	405..494	CDD:238020	24/105 (23%)
		FN3	511..574	CDD:238020	24/78 (31%)
		FN3	583..671	CDD:238020	21/91 (23%)
		fn3	683..753	CDD:278470	10/69 (14%)
		fn3	787..850	CDD:278470	18/65 (28%)
		fn3	866..935	CDD:278470	17/71 (24%)
		fn3	961..1043	CDD:278470	12/84 (14%)
		PTPc	1272..1525	CDD:214550	118/256 (46%)
		PTPc	1298..1525	CDD:238006	109/228 (48%)
ptprfa	XP_021332435.1	I-set	33..124	CDD:254352
		Ig2_RPTP_IIa_LAR_like	152..232	CDD:319301
		Ig3_RPTP_IIa_LAR_like	256..324	CDD:143216	1/3 (33%)
		FN3	329..418	CDD:238020	19/102 (19%)
		FN3	425..517	CDD:238020	25/104 (24%)
		FN3	522..610	CDD:238020	12/87 (14%)
		fn3	618..705	CDD:306538	20/96 (21%)
		FN3	720..816	CDD:238020	26/99 (26%)
		FN3	821..902	CDD:238020	27/163 (17%)
		FN3	919..1007	CDD:238020	22/98 (22%)
		FN3	1017..1086	CDD:238020	17/72 (24%)
		PTPc	1388..1617	CDD:238006	110/229 (48%)
		PTPc	1678..1908	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910