DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and AgaP_AGAP011650

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_320862.4	Gene:	AgaP_AGAP011650 / 1280988	VectorBaseID:	AGAP011650	Length:	1111	Species:	Anopheles gambiae

Alignment Length:	1184	Identity:	285/1184 - (24%)
Similarity:	477/1184 - (40%)	Gaps:	253/1184 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 DVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVY 582
            ||::.|...: .:::....:|.:....:....|..|.||    |:..:.|.|...:|    |.|
Mosquito     2 DVSTPQLPLD-YFAKTSHIELPSNAIPKVLSAIPPLCPG----LRARSSSGDAIIKP----QTV- 56

  Fly   583 PNPPRNMTIETVRSNSVLVHWSPPESGE--FTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKG 645
             .|.|::...|....|||:.|.||:.|.  ..||.|.:.::|    ..:.:.| |..::|::...
Mosquito    57 -GPVRDLRANTDLDRSVLLSWRPPKEGAVCVKEYLITWSSES----ATIDASR-TVYNVTNLEPC 115

  Fly   646 EKYTIQVNTVSFGVESPVPQEVNTTVPP-NPVSNIIQL----VDSRNITLEWPKPEGR---VESY 702
            ..|...||.:....:...|:.::.||.. ..:|.:.:|    |:.|:::::|..|...   ||||
Mosquito   116 MTYEFTVNAIDHTNDKGTPESISATVRELQQLSQVTELELNEVEPRSLSVKWKPPTNGTFCVESY 180

  Fly   703 -ILKWWPSDNPGR-VQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSL-- 763
             ::.|:  :||.. .....|..|.:.|.    .|..||::..:.|...:...|.....|:..:
Mosquito   181 RVVAWY--NNPANSADVTEVFSNTTTDQ----HVTFGEVIACMSYTVQVIPISISKHDGLNEIGT 239

  Fly   764 ---YPRTM-----------------PLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRF 808
               ..||:                 ||:.......|.:.::    |.....|||       .|.|
Mosquito   240 IKTKERTILFYHVEPIRAIALSIVEPLVPYSTYECNAKIQN----IAGWSDPTP-------AYTF 293

  Fly   809 SLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNI-TVW---TVSGGVA---SLPIQRQDRLYPEP 866
                       ..|.|.....:...|: |:..:| .:|   ||..||.   .:.::.....||.|
Mosquito   294 -----------VTAEDVPESPSVIELI-GKNRSIGIIWKAPTVKNGVVVRYRIHVRMVAPEYPLP 346

  Fly   867 --ITQLHATNITDTEISLRWDLPKGEYNDFD-IAYLTADNLLAQNMTTRNEITISDLRPHRNYTF 928
              ...|...|.|   :.||.::...|...:| |.:               |..::.|.|:..|..
Mosquito   347 KLCAPLEEFNET---VDLRDEVNPDESRSWDGIEF---------------EHVVAKLNPYTLYLV 393

  Fly   929 TVVVRSG---------TESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQ---PSEINFEWSLP 981
            .|...:|         .|...|...|.::|||        |:::....::.   .|.:.|.|.||
Mosquito   394 QVAAATGAGFGPYTEPVEVVTLPDVSNVTASF--------RIDKIEGPELNQTYKSSVWFGWDLP 450

  Fly   982 SSEANGVIRQFSIAYTNINNLTDAGMQD-------------FESEEAFGVIK----NLKPGETYV 1029
            .. .||.:::|      :..:.....||             .|.||...|..    .|||...|.
Mosquito   451 CG-LNGRLKRF------VGEMYGIREQDPSNPHALTWEVNVGEEEEILDVYSYVEDRLKPEYNYT 508

  Fly  1030 ----------------FKIQAKTAIGFGPEREYRQ---TMPILAPPRPATQVVPTEVYRSSSTIQ 1075
                            .|:|.::..|. |..:.::   .:.:...|.|            ::|.:
Mosquito   509 VAIRVEVVAVEELSDEVKVQFESPAGI-PSIDQKEEWFNVDVFEAPNP------------TNTAR 560

  Fly  1076 IRFRKNYFSDQNGQVRMYTIIVAE-----------DDAKNASGLEMPS---WLDVQSYSVWLPYQ 1126
            |.......:...|.:|...::|:|           |...:..|.:.||   |...........||
Mosquito   561 IMLGNITLTSDIGSIRYMALLVSERLCQPDPTPRTDFINSTGGTQWPSVPDWYLANEKRCAEQYQ 625

  Fly  1127 AIDPYY-PF----------ENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKF 1180
            ....:: |.          |...:.::.||.|:||..: .|||||||.||.|.:.||.|:.:. :
Mosquito   626 TTPKFWNPMARGQRATTDREAAGLIEYVIGKEDCDRGQ-EYCNGPLKPGTEYALIVRIFSRSG-Y 688

  Fly  1181 TDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTL--LFYKRRRNNCRKTTKDSRANDNMSLPD 1243
            ||:    .:|..:.::.:.|.:.|...:..::|..|  ||...|:.......:.:|.
Mosquito   689 TDS----EMQVFRTDSLIKVGLIVSAVLACLVLAFLGGLFVVWRKQRLLLPAQQTRG-------- 741

  Fly  1244 SVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKH---VGRDQPCTFADLPCNRPKNRFTNI 1305
            :..|:...|.:|||...|..:...:..:.|:||:.:.:   .......:|.....|..|||:.||
Mosquito   742 APTEEPADIPVKNFPHQYDELFQSNREKVSKEFQAINYFSDFALQDTVSFQSARENERKNRYVNI 806

  Fly  1306 LPYDHSRFKLQPVDDDE-----GSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSR 1365
            ||||.:|..|...:|.|     .:|||||:::.|:...||:|.||||...|..|||||..:....
Mosquito   807 LPYDSNRVLLDSNEDGEEGEYGANDYINASFIEGYKYQREYIATQGPKQETCADFWRMVLQYEIE 871

  Fly  1366 AIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFH 1430
            :|||||:..:..:.||.||:|.......||||:|:...:.:.:.:....|::.:|:..:.:.|:|
Mosquito   872 SIVMLTQPIDHDKNKCCQYFPRFDQYTDYGDIRVKCTQELNLSLYYKRLFLVSKGNLTKAVFHYH 936

  Fly  1431 FTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQR----PIVVHCSAGVGRSGTFITLDRILQQINTS 1491
            |..|||...|.....|::|.:..|    ||::    |:||||||||||:||||.||.:||::...
Mosquito   937 FLEWPDHSCPASTADLIKFSKIVR----AERKSYAIPLVVHCSAGVGRTGTFIALDIVLQRLQQE 997

  Fly  1492 DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDE 1556
            ..::::..|..:|::||.||||..||..::||.:..: .|.|     |:.......|  .::.||
Mosquito   998 KKINVYDTVKQLRRQRVKMVQTLDQYTFLYQCCMEYV-SKSN-----RKKPKTSNIE--IIRRDE 1054

  Fly  1557 NG-----DVVATIE 1565
            .|     ||:..:|
Mosquito  1055 KGKQHYPDVILEVE 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020	11/55 (20%)
		FN3	583..671	CDD:238020	21/89 (24%)
		fn3	683..753	CDD:278470	18/74 (24%)
		fn3	787..850	CDD:278470	14/66 (21%)
		fn3	866..935	CDD:278470	14/71 (20%)
		fn3	961..1043	CDD:278470	21/117 (18%)
		PTPc	1272..1525	CDD:214550	97/264 (37%)
		PTPc	1298..1525	CDD:238006	92/235 (39%)
AgaP_AGAP011650	XP_320862.4	FN3	57..142	CDD:238020	22/89 (25%)
		FN3	148..227	CDD:238020	20/84 (24%)
		FN3	298..414	CDD:238020	27/134 (20%)
		Y_phosphatase	797..1032	CDD:278528	93/238 (39%)
		PTPc	800..1029	CDD:238006	90/232 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810