DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and AgaP_AGAP010090

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_319248.3	Gene:	AgaP_AGAP010090 / 1279520	VectorBaseID:	AGAP010090	Length:	1229	Species:	Anopheles gambiae

Alignment Length:	1015	Identity:	271/1015 - (26%)
Similarity:	431/1015 - (42%)	Gaps:	158/1015 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 SPVPQEVNTTVP--PNPVSNIIQLVDSRNITLEWPKPE---GRVESYILKWWPSDNPGRVQTKNV 720
            :|:..:....||  |.....|::...:.:|.|||.:|.   |.:..|.::|..     |.|..|
Mosquito     4 APISVKTPGGVPIRPTVTLKILERDPTVSIELEWERPRQTYGELRGYRVRWGV-----REQALN- 62

  Fly   721 SENKSADDLSTVRVLIGELMPGVQYKFDIQTTSY-GI-LSGITSLY-PRTMPLIQSDVVVANGEK 782
            .|......|:..|  |.:|..||:|:|.:...:: || ...:..|. |...|......:....:.
Mosquito    63 EEILQGTQLNVKR--INDLERGVEYEFRVAGMNHIGIGQEAVKHLQTPEGSPTGPPTGIAVRFQT 125

  Fly   783 EDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDK-------EKLANDTDRKVTFTGLVPGRLY 840
            .   |.:.:::.|..:......|.|:   |.:...|       |:  |.|.||..||.|.....|
Mosquito   126 P---DVVCITWEPPTREHRNGQITRY---DVQFHKKIDHGLGTER--NTTVRKAVFTNLDESTEY 182

  Fly   841 NITV--WTVSGG---VASLPIQRQDRLYPEPITQLHATNITDTEISLRWD-LP-KGEYNDFDIAY 898
            .:.|  :|..|.   ...:.|..:..:...|.: :.|...::..:.:.|: :| :|:...:.|.|
Mosquito   183 IVRVRAYTKQGAGPFSEKVVIATERDMGRAPFS-VQAVATSEQTVEVWWEPVPSRGKLVGYKIFY 246

  Fly   899 -LTADNLLAQNMTTRNEITIS----DLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVP 958
             :||...|.:..|....:|.|    :|.....|...:.....|....|...:.:...   .|.||
Mosquito   247 TMTAVEDLDEWQTKVVGVTESADLINLEKFAQYAVAIAAMYKTGLGKLSEKATVKVK---PEDVP 308

  Fly   959 GRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDA-GMQD----------FES 1012
            ..: |.|  ||....:...|: |....|.:  .:.|::..:....|: |:..          .:|
Mosquito   309 LNL-RAH--DVSTHSMTLSWA-PPIRMNPI--NYKISFDAVKEFVDSQGISQKQILPRKEIILKS 367

  Fly  1013 EEAFGVIKNLKPGETYVFKIQA-KTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQI 1076
            ......|..|.|..||...:.| .|...:.|..:...|.. :|.|:|   :|..:.|...:..:|
Mosquito   368 HVKSHTISELSPFTTYFVNVSAVPTDYSYKPPAKITVTTQ-MAAPQP---MVQPDFYGVVNGEEI 428

  Fly  1077 RFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLE--------MPSWLDVQSYSVWLPYQAIDPYYP 1133
            :......|::.|.:..|.:||..:|..|...:.        :||...:...:.  ||.|.    .
Mosquito   429 QVILPQASEEYGPISHYYLIVVPEDKANLHKIPDQFLTEELLPSRPKLDRLNA--PYIAA----M 487

  Fly  1134 FENRSVE-DFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADK---FTDTAYS-------- 1186
            |..|::. .|.:|:.. .||  .:.|..|:.|..||:.|||.....:   :|.:.:|
Mosquito   488 FLQRNIPYTFHLGSGE-TNH--NFTNKKLERGKRYRIFVRAVVDTPQKHLYTSSPFSEFLALDMK 549

  Fly  1187 --------FPIQTDQDNTSLIVAITV---------PLTIILVLLVTLL---FYKRRRNNCR---- 1227
                    .||.|.:....|.....:         |:...|||.|..|   |.:|||..|:
Mosquito   550 EAPTNHRIVPIPTFRRIRKLSFVAKMKSRACFGVGPIIAALVLSVCFLVVYFVRRRRQPCKAPDQ 614

  Fly  1228 -KTTKDSRAND----------------NMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEE 1275
             ..|:...|.|                |...|..:  .:.||.|...|.|...:.|:.:.:||:|
Mosquito   615 AAVTRPLMAADLGAGPAPTDPVDMRRINFQTPGMI--SHPPISIAELANHVERLKANDNLKFSQE 677

  Fly  1276 FEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPRE 1340
            :|.:: .|:......:::..|:||||:.|:..|||||..|.|::...|||||||||..|:.....
Mosquito   678 YESIE-PGQQFTWDHSNMEVNKPKNRYANVTSYDHSRVILPPIEGVPGSDYINANYCDGYRKHNA 741

  Fly  1341 FIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDS 1405
            ::.|||||..|..||||||||..|..|||:||..|:.|.|||.|||.....| ||.:.|.|....
Mosquito   742 YVATQGPLQETFGDFWRMCWELKSSTIVMMTRLEERSRIKCDMYWPARGTEV-YGAMTVTITETQ 805

  Fly  1406 HYADWVMTEFMLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHC 1468
            ..|.:.:..|.:.|  .:|:|.::...||.|||.|||:.|...::|:|..:....:|..||:|||
Mosquito   806 ELATYSIRTFQIYRNGSNERREIKQLQFTAWPDHGVPDHPAPFLQFLRRTKSLTPSESGPIIVHC 870

  Fly  1469 SAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEGKE 1532
            ||||||:|.:|.:|.:|:::.....:||:|.|..:|.:|.:|||||.|||.||..|| ||:.|..
Mosquito   871 SAGVGRTGCYIVIDSMLERMKYEKTIDIYGHVTCLRAQRNYMVQTEDQYIFIHDALLEAVICGST 935

  Fly  1533 NIVGPAREMHD----------NEGYEGQQVQLDENGDVVA 1562
            .:  |||.:|:          :|...|.:::..:..:|.|
Mosquito   936 EV--PARSLHNHIQKLMQTEPHENITGMEMEFKKLSNVKA 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	1/9 (11%)
		fn3	683..753	CDD:278470	20/72 (28%)
		fn3	787..850	CDD:278470	17/71 (24%)
		fn3	866..935	CDD:278470	15/75 (20%)
		fn3	961..1043	CDD:278470	18/93 (19%)
		PTPc	1272..1525	CDD:214550	109/254 (43%)
		PTPc	1298..1525	CDD:238006	103/228 (45%)
AgaP_AGAP010090	XP_319248.3	fn3	22..100	CDD:278470	23/85 (27%)
		FN3	114..205	CDD:238020	19/98 (19%)
		fn3	212..295	CDD:278470	16/83 (19%)
		FN3	308..390	CDD:214495	17/87 (20%)
		PTPc	673..928	CDD:214550	110/256 (43%)
		PTPc	699..928	CDD:238006	104/229 (45%)
		PTPc	960..1219	CDD:214550	3/14 (21%)
		PTPc	988..1219	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910