DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and AgaP_AGAP006083

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_316139.4	Gene:	AgaP_AGAP006083 / 1276754	VectorBaseID:	AGAP006083	Length:	1502	Species:	Anopheles gambiae

Alignment Length:	1303	Identity:	267/1303 - (20%)
Similarity:	425/1303 - (32%)	Gaps:	427/1303 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLYQLSKATTRIRLKRQKAVPQHRW---------LWSLAFLAAFTLKDVRCADLAISIPNNPGLD 56
            ||....:|..:: |:..|..|..||         :....|.:..|...:..:    |:.:|.||.
Mosquito    24 MLQCAGRADRKV-LQDGKVAPNIRWRGPDGQDIGIVGDTFRSQLTNGSLYIS----SVESNRGLT 83

  Fly    57 ---------DGASYRLDYSPPFGYPE-PNTTIASREI----GDEIQF---SRALPGTKYNFWLYY 104
                     ||....:..|......: |:....|.||    |....|   |..||   |:....|
Mosquito    84 GFYHCLLSVDGIGTIVSRSARVAIADLPDINQESHEIYLYAGQTAYFKCMSSLLP---YSIESRY 145

  Fly   105 TNFTHHDWLTWTVTITTAPDPPSNLSVQ----VRSGKNAIILWSPPTQGSYTAFKIKVLGLSEAS 165
                |.:||        ..|.|..:.:.    :.||...|....|..:|:|.. .:.....|..|
Mosquito   146 ----HTEWL--------KDDLPLRMDLTRMLLLPSGALEIDEVVPADRGTYQC-NVTAGTFSRLS 197

  Fly   166 SSYNRTFQVNDNTFQHSVKELTPGATYQV-QAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRN 229
            |..|    :|..:.....:...|.|...| |..|:.:|...:...:.|...||.     |.|.||
Mosquito   198 SKSN----LNIKSTAGQPQSFAPPAFVIVPQPQTVREGDTVILDCAANGNPKPT-----IRWLRN 253

  Fly   230 -----------------ETTLLVLWQPPYPAGIY--------------THYKVSIEP-----PDA 258
                             ..:|.:.......||.|              ...:|.:.|     ||
Mosquito   254 GEDIDMNDLDSRFRIMGTGSLQINSIQDTDAGDYQCRASNTEDSLDASATVQVQVPPKFILSPD- 317

  Fly   259 NDSVLYVEKE--------GEPPGPAQ----------AAFKGLVPGRAYNI--------------- 290
             |.|.|.::|        |:|....|          :.:..:|.|....|
Mosquito   318 -DKVAYEKEELELTCSIHGKPTPIIQWLKNGDLITPSEYMQIVGGHNLKIFGLIGSDAGMFQCIG 381

  Fly   291 -----SVQTMSEDEISLP--TTAQYRT-------------VPLRPLNVTFDRDFITSNSFR---- 331
                 |||..:..||..|  |..||.:             :|.|.....|.:....:.|:.
Mosquito   382 TNPAGSVQAAARLEIIEPGVTRTQYHSDKSGTLRLQTTSGLPKRHKGKKFQQTQSKTKSYEKSPL 446

  Fly   332 VLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFR----------------------DI 374
            :|...||    ..|..:....:|.::....:|:..|..|..                      |.
Mosquito   447 LLQSDPK----LSKSVLDSLVSRTKARPKYTNDDYADHDRMLDSDHDVDDDDDEDDEDEDEDDDD 507

  Fly   375 AEPGKTF--------NVIVKTVSGKVT-----------SWPAT--GDVTLR-------------- 404
            .|.||.:        |.:.:|::|..:           |.|.:  ..||.:
Mosquito   508 EEEGKIYPLRPNEDPNKLYQTLTGSRSREDGGELVGHFSNPKSPLNAVTRKYSKSSYADGSGKFA 572

  Fly   405 ---PLPVRNLRSINDDKTNTMIITWEADPASTQDE---YRIVYHELETFNGD--TSTLTTDRTRF 461
               |.|.|.|:: ...::..:.::| .:||...||   |. ||:.:.|.:.:  .:|.:.|....
Mosquito   573 APLPGPPRTLQA-QIVQSRFITLSW-LEPAKNPDEVISYS-VYYRMHTSDRERKMTTKSRDEQEI 634

  Fly   462 TLESLLPGRNYSLSVQAVSK--KMESNETSIFVVTRPSSPIIEDLKSIR------MGLNISW--K 516
            .::||.||:||...|...|.  ..||:|| :.|.|.....|....:::|      ..:::.|  .
Mosquito   635 NIQSLQPGKNYHFRVVGNSNHGPGESSET-LEVRTLSEENIAGAPQNLRGYAITEKDIHLQWDPP 698

  Fly   517 SDVNSKQEQYEVLYSR--NGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEP-HAYF 578
            :..|....:|.|.|:.  ||.:::... |..:..::..|:|...|.:.|...:.....:| |...
Mosquito   699 AITNGMIAKYRVYYAETDNGMTEMYAD-TTTTEAILNELRPYTKYTMYVVPFNQAGMGDPSHEID 762

  Fly   579 QAVYPN----PPRNMTIETVRSNSVLVHWSPP----ESGEFTEYSIRYRTDSEQQWVRLPSVRST 635
            ...|.:    ||.|:|:||..|.||.:.|.||    .:|:.|.|.|:||.:.:..     .|.:|
Mosquito   763 VKTYSSTPSEPPANVTLETTSSTSVAIRWEPPALEDRNGQITGYKIKYRKNKKPL-----QVETT 822

  Fly   636 EADI-----TDMTKGEKYTIQVNTVSFGVESPVPQ--EVNT--------TVPPNPVSNIIQLVDS 685
            .|::     .::.|...|.:::..::.....|..:  .:.|        .||..|.     .:.:
Mosquito   823 PANVRYYILKELDKMSAYQVKIAAMTINGTGPFTEWHHIETYENDLDESQVPGQPA-----WLKT 882

  Fly   686 R----NITLEWPKP---EGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVL-IGELMPG 742
            |    |||:.|..|   |.:|.||||.|          .|.:.:..:|:....:|.. |..|.|.
Mosquito   883 RPGADNITVTWGPPVHQEIKVRSYILGW----------GKGIPDEDTAEIEERMRYFEIPNLEPN 937

  Fly   743 VQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYR 807
            .:|              :.||..|.          |.|:...:.||
Mosquito   938 SEY--------------VISLRARN----------AMGDGAPKYDT------------------- 959

  Fly   808 FSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPI---TQ 869
                   :|.:|                                 ..||:.     |.|:   ..
Mosquito   960 -------VRTRE---------------------------------DAPIEA-----PTPLEVPVG 979

  Fly   870 LHATNITDTEISLRW---DLPKGEYNDFDIAYL-----TADNLLAQNMTTRNEITISDLRPHRNY 926
            |.|..::.|.|.:.|   .|.|.::...:..|:     ...|....:.|:.....|.||||:..|
Mosquito   980 LRAIPMSGTSIVVYWTDTTLSKSQHVSDNRHYVVRYSPNGSNRYRYHNTSVLSSMIGDLRPNTQY 1044

  Fly   927 TFTVVV-----RSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQ-------PSEINFEWS 979
            .|.|.|     :|....|||.|:.|.|      ...|       |.|:|       |......|.
Mosquito  1045 EFAVKVVKGHRQSAWSMSVLNSTQPAS------PVSP-------PRDLQVTFDPRNPLTALLSWL 1096

  Fly   980 LPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFG-----VIKNLKPGETYVFKIQAKTAIG 1039
            .| ...:|.|..:.:.||..|...|   :|:..|...|     .|.:|:|..||.||:|.:.:.|
Mosquito  1097 SP-RHVSGPIAGYQVLYTTDNTKRD---RDWNIESTTGEHTSAEILHLEPHTTYYFKVQTRHSKG 1157

  Fly  1040 FGP 1042
            .||
Mosquito  1158 LGP 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	19/85 (22%)
		fn3	220..304	CDD:278470	28/159 (18%)
		fn3	315..391	CDD:278470	16/109 (15%)
		FN3	405..494	CDD:238020	28/95 (29%)
		FN3	511..574	CDD:238020	12/66 (18%)
		FN3	583..671	CDD:238020	25/110 (23%)
		fn3	683..753	CDD:278470	20/77 (26%)
		fn3	787..850	CDD:278470	4/62 (6%)
		fn3	866..935	CDD:278470	20/84 (24%)
		fn3	961..1043	CDD:278470	26/94 (28%)
		PTPc	1272..1525	CDD:214550
		PTPc	1298..1525	CDD:238006
AgaP_AGAP006083	XP_316139.4	Ig	8..107	CDD:299845	17/87 (20%)
		IG_like	12..95	CDD:214653	15/75 (20%)
		IG_like	117..189	CDD:214653	21/87 (24%)
		Ig	<149..204	CDD:299845	14/67 (21%)
		I-set	217..306	CDD:254352	16/93 (17%)
		IGc2	230..293	CDD:197706	12/67 (18%)
		I-set	310..396	CDD:254352	16/87 (18%)
		Ig	331..396	CDD:299845	9/64 (14%)
		FN3	576..668	CDD:238020	28/95 (29%)
		FN3	676..765	CDD:238020	15/89 (17%)
		FN3	772..863	CDD:238020	24/95 (25%)
		FN3	874..955	CDD:238020	27/119 (23%)
		FN3	977..1063	CDD:238020	20/85 (24%)
		FN3	1074..1169	CDD:238020	27/98 (28%)
		Neogenin_C	1236..1497	CDD:284094
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910