DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and AgaP_AGAP005352

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_315365.3	Gene:	AgaP_AGAP005352 / 1276060	VectorBaseID:	AGAP005352	Length:	515	Species:	Anopheles gambiae

Alignment Length:	550	Identity:	141/550 - (25%)
Similarity:	229/550 - (41%)	Gaps:	116/550 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1296 NRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCW 1360
            ||..||:.::|||||||..|:   ..|| ||||||.|....:.|::|:.||||..|...||.|.|
Mosquito    26 NRRLNRYRDVLPYDHSRVALK---RGEG-DYINANLVKMERAGRKYILCQGPLPHTVGHFWMMVW 86

  Fly  1361 ESNSRAIVMLTRCFEKGREKCDQYWP-----NDTVPVFYGDIKVQILNDSHYADWVMTEFMLC-- 1418
            |.:||||:||.:..|:...||.||||     ...:.:....:.|..|....|.::....|.|.
Mosquito    87 EHDSRAILMLNKLIEQTTVKCHQYWPAKIGEKHRLELTGVQLSVVHLKCVEYKNFCKRTFRLTDM 151

  Fly  1419 -RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRD--RIGAEQRPIVVHCSAGVGRSGTFIT 1480
             .|..:.::: ||:|||||||:|:.|...::|::..||  .:..:..|.::|||||:||||||..
Mosquito   152 ESGKSREVIQ-FHYTTWPDFGIPSSPVAFLQFLKEVRDSGTLDRDVGPPIIHCSAGIGRSGTFCL 215

  Fly  1481 LDRILQQINT--SDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHD 1543
            :|..|..::.  .|.|.:..::..:|:.|:.::||..|....:|   |::||.:.:
Mosquito   216 VDCCLVLVDKEGEDRVSVQDVLLELRQYRMGLIQTPDQLYFSYQ---AIIEGMKRM--------- 268

  Fly  1544 NEGYEGQQVQLDENGDVVATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQPL----TSSFTGHH 1604
                         |..|..|:....|..:..|.:.|           |...||    |.|.|...
Mosquito   269 -------------NNSVKLTVVASSSQQNSDQEDNE-----------DTPPPLPPPRTHSLTSKP 309

  Fly  1605 THMPPTTSMSS----FGGGGGGHTNVDAPDRXHSVVNQSDNN--NSVVIVLVDNKPSSMICKDS- 1662
            ..:.||:....    .||..||..     |:.:::.:...||  |:.......|:|...|.:||
Mosquito   310 LPVIPTSESVHEDFLLGGSNGGDR-----DKVNNLRSDGSNNHHNNHHHHPYSNRPLPPIVRDSS 369

  Fly  1663 ---------------KGGNIDVLESQQQQQQQQQQQPNQG--GHNITTISAINGYNTLQHRRKSQ 1710
                           ...:|...|.::...:.:.::.|:|  |.::.:.:..|..::|...
Mosquito   370 LDSNAMSSEDELIEENDSDIGEEEEEEDDDEAELEEKNRGTIGRDVPSDNTFNANSSLPPL---- 430

  Fly  1711 LITFSSSSCDIKNSLSHEYINGSNGSAANGPPSSGSGSGS-GPGSNRASRANV-RLSFAEEDVMI 1773
                                  .||:..:|..:..|.... .||:....|..: |.|..||.:..
Mosquito   431 ----------------------PNGALDDGDDAISSPERELSPGAELRRRKRIERQSAMEEKIRE 473

  Fly  1774 LPQNHSQQSNHQDDEVFTRRRSLLEVEIGV 1803
            :.:...:..:....:  .||..|..:..||
Mosquito   474 IKRKRKEVESKGSPK--KRRLLLFSLAAGV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	88/240 (37%)
		PTPc	1298..1525	CDD:238006	86/238 (36%)
AgaP_AGAP005352	XP_315365.3	PTPc	15..263	CDD:214550	89/244 (36%)
AgaP_AGAP005352	XP_315365.3	PTPc	29..263	CDD:238006	87/241 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910