DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and AgaP_AGAP004246

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_003436753.1	Gene:	AgaP_AGAP004246 / 1274091	VectorBaseID:	AGAP004246	Length:	1967	Species:	Anopheles gambiae

Alignment Length:	2049	Identity:	1251/2049 - (61%)
Similarity:	1481/2049 - (72%)	Gaps:	224/2049 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ADLAISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNF 107
            |||.|.||.|.|||| :.|||||.||.|.|.||.|||||::|||||||..||||:|||||||||.
Mosquito    10 ADLVIEIPGNQGLDD-SFYRLDYYPPIGNPAPNATIASRDVGDEIQFSNGLPGTRYNFWLYYTNS 73

  Fly   108 THHDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTF 172
            ||.|||||||:||||||||:||:|..|||||.||.||||.||:|::||:|:||||: :.:.|:|.
Mosquito    74 THKDWLTWTVSITTAPDPPANLTVIPRSGKNVIINWSPPAQGNYSSFKLKILGLSD-NFATNQTV 137

  Fly   173 QVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLW 237
            .:.||.||:.|::|||||||||||||:||||||||||||||||||||||||||||||||||||||
Mosquito   138 AIEDNQFQYMVRDLTPGATYQVQAYTLYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLW 202

  Fly   238 QPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISL 302
            |||||||||||||||||||||..|||||:||||||||||||||||||||||||||||||||||||
Mosquito   203 QPPYPAGIYTHYKVSIEPPDALGSVLYVQKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISL 267

  Fly   303 PTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRS-NEPV 366
            |||||||||||||:|||||:..||.|||:|:||||||.|||||||||::|:|||..|.|: ||.:
Mosquito   268 PTTAQYRTVPLRPMNVTFDKKSITENSFKVMWEAPKGTSEFDKYQVSLSTSRRQQAVLRNDNENM 332

  Fly   367 AFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPA 431
            |:.:|:|..:||||:.|:|||||||||||||:|||||:||||:.|:|..|.||..:.|:|:.|..
Mosquito   333 AWLEFKDNLDPGKTYQVVVKTVSGKVTSWPASGDVTLKPLPVKQLQSYTDSKTGVITISWKPDEL 397

  Fly   432 STQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRP 496
            ||||||||.||||||.|||:||::|::|.|.|||||||||||::|||:|:|||||||.|||||||
Mosquito   398 STQDEYRISYHELETNNGDSSTMSTNQTSFALESLLPGRNYSVTVQALSRKMESNETVIFVVTRP 462

  Fly   497 SSPIIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYEL 561
            ||||||||||||.||||||||||||||::|||.|:||.|:|.:|..|.|||||..||.||||||:
Mosquito   463 SSPIIEDLKSIREGLNISWKSDVNSKQDKYEVTYTRNDTNDGKTVLTTESRLVFTNLYPGAGYEV 527

  Fly   562 KVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQW 626
            |||||||.||||||:||||||||||||||||.|.||||||||.|||..|||||||||||:||:||
Mosquito   528 KVFAVSHGLRSEPHSYFQAVYPNPPRNMTIEKVTSNSVLVHWKPPERSEFTEYSIRYRTESEKQW 592

  Fly   627 VRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLE 691
            :|||||::||||:||||.||||||||||||:|||||.||:||.||.|||||||..||||.|||||
Mosquito   593 IRLPSVKATEADVTDMTPGEKYTIQVNTVSYGVESPNPQQVNQTVRPNPVSNIAPLVDSNNITLE 657

  Fly   692 WPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGI 756
            :|:||||||:||:.|||::.|.:|..||.:|..:...|  ||:|||:||.||.|.|.|||.|||:
Mosquito   658 FPRPEGRVETYIIHWWPTEQPEQVSMKNFTEVNTKPPL--VRLLIGDLMSGVMYNFKIQTISYGL 720

  Fly   757 LSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKL 821
            .|.:|.|..||||||||:||:.|  ....||.:|||||||||.|||||:|||||||..|.|||||
Mosquito   721 TSDLTKLQTRTMPLIQSEVVIVN--NMHTRDMVTLSYTPTPQQSSKFDLYRFSLGDPSIPDKEKL 783

  Fly   822 ANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDL 886
            |||||||||||||.||||||||||||||.|:|.|||||||::|:|||.|.||:|.||.|:|:||:
Mosquito   784 ANDTDRKVTFTGLTPGRLYNITVWTVSGKVSSQPIQRQDRMFPDPITMLEATSINDTWIALKWDI 848

  Fly   887 PKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASF 951
            |||||..|::.||..|:...||.|..|.|||:||:||||||.||||||||||||||.|.|:||:|
Mosquito   849 PKGEYTSFEVQYLMNDSHYVQNYTVNNHITITDLKPHRNYTITVVVRSGTESSVLRVSLPISANF 913

  Fly   952 TTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAF 1016
            .|.||:|||:::|.|.|:|||||.||||||.:|.||:||||:|.| .::......::||...|..
Mosquito   914 QTKEALPGRMDKFAPIDIQPSEITFEWSLPPNEQNGIIRQFTITY-GLDGSQHTQVKDFRPNELR 977

  Fly  1017 GVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKN 1081
            |.||.|:||::|||:||||||||:|||..::|.|||||||:|.||||||||..|::||:|||||:
Mosquito   978 GSIKALQPGKSYVFRIQAKTAIGYGPEHIWKQKMPILAPPKPETQVVPTEVGSSATTIEIRFRKH 1042

  Fly  1082 YFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGT 1146
            |||||||.|..||||:||||:|||||||||||.||||||||.|||.|:|||||:|.|||||||||
Mosquito  1043 YFSDQNGVVTTYTIIIAEDDSKNASGLEMPSWRDVQSYSVWPPYQVIEPYYPFKNSSVEDFTIGT 1107

  Fly  1147 ENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILV 1211
            ||||..|.|||||||||||||:|||||||..|||||||||:||:|.||||||||:|||||.||.:
Mosquito  1108 ENCDAKKTGYCNGPLKSGTTYKVKVRAFTAPDKFTDTAYSYPIRTAQDNTSLIVSITVPLLIIAM 1172

  Fly  1212 LLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEF 1276
            |:..:||.:|||:..|||| :.|.|||||||||.||.:||:|:||||||||:|||||||||||||
Mosquito  1173 LVGVVLFLRRRRHTGRKTT-EQRTNDNMSLPDSTIETSRPVLVKNFAEHYRMMSADSDFRFSEEF 1236

  Fly  1277 EELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREF 1341
            |||||:||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
Mosquito  1237 EELKHIGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDEEGSDYINANYVPGHNSPREF 1301

  Fly  1342 IVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSH 1406
            |||||||||||||||||||||||||||||||.|||||||||.|||:|||||:||||||.:|||||
Mosquito  1302 IVTQGPLHSTRDDFWRMCWESNSRAIVMLTRTFEKGREKCDHYWPHDTVPVYYGDIKVTLLNDSH 1366

  Fly  1407 YADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAG 1471
            |.|||:||||:.||.:|||:||||||||||||||||||||.|||||||:|:|.:|||||||||||
Mosquito  1367 YPDWVITEFMMTRGEQQRIIRHFHFTTWPDFGVPNPPQTLARFVRAFRERVGPDQRPIVVHCSAG 1431

  Fly  1472 VGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVG 1536
            |||||||||||||||||..||||||||||:||||||||||||||||||||||||.||||||   |
Mosquito  1432 VGRSGTFITLDRILQQIQVSDYVDIFGIVWAMRKERVWMVQTEQQYICIHQCLLVVLEGKE---G 1493

  Fly  1537 PAREMHDNEGYE-----GQQVQ--------LDENGDVVATIEGH--------LSHHDL---QQAE 1577
            ..||:|||:|||     .||.:        .|:..|.||..|.|        :.:|:|   :.|.
Mosquito  1494 TEREIHDNQGYEEPRDDDQQSEEQLLIENRSDDELDEVAVREQHQQNGTAGGIENHELDRRRSAT 1558

  Fly  1578 AEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSSFGGGGGGHTNVDAPDRXHSVVNQSDNN 1642
            .|.:|:|...:    ||   ::||...|                  |..:..|....|....|.
Mosquito  1559 VEIVDNELVMM----QQ---ANFTAGET------------------TEEELLDEEEEVEVTVDG- 1597

  Fly  1643 NSVVIVLVDNKPSSMICK-DSKGGNIDVLESQQQQQQQ----------QQQQPNQG--------- 1687
                :::|..|.|.:... .:.||     :.|||:|.|          ::.||:.|
Mosquito  1598 ----LMIVSRKQSHVSSSTPAMGG-----DGQQQEQHQHSNSNSASNNERDQPSSGQDERSISSN 1653

  Fly  1688 GHNITTISAINGYNTLQHRRKSQLITFSSSSCDIKNSLSHEYINGSNGSAANGPPSSGSGSGSGP 1752
            |.| :..||.:||.:..|:|:| |...|......:.|||  :..|.....:...||||...
Mosquito  1654 GTN-SNNSANSGYESSPHKRRS-LAATSQERVHDRRSLS--FSTGGAEIVSKADPSSGDHQ---- 1710

  Fly  1753 GSNRASRANVRLSF----------AEEDVMILP--QNHSQQ--------------SN-------- 1783
            ..::..:..|:.::          .::...:||  |:||.|              ||
Mosquito  1711 QQHQQQQQQVQQTYQVGGPLQQQQQQQHQAVLPPGQHHSHQPTVGGGKLHVNSNASNVVILRADG 1775

  Fly  1784 HQDDEVFTRRRSLLEVEIGVEVGEDGE------------------LAPHEMEEDLEEEDEDE--- 1827
            ..||.....:....|::.|::..::|:                  ...|:.::|.::||:::
Mosquito  1776 DDDDRTMATKDDETEIDDGIDGSDEGDDDLNAVEEVNGRDGKRCGQVEHDDDDDDDDEDDEQTHE 1840

  Fly  1828 --ELYMHDEFETHI-------------DTKSNNANDDSGG--------GSYEDSHALHSSLGGSN 1869
              ||.:|...|.::             ...:|.:::..||        |.|:     |.|.
Mosquito  1841 QRELLLHRRNERNVRAVAAAMVAGAAAGAVANGSSNGGGGVVGPGCGVGRYK-----HHSY---- 1896

  Fly  1870 RNSLEKDDDDIEVDVISTDVSCYDQLLGSSCNTRNGDDDDIATLVGDGDYSTTKLSKASRLSGAG 1934
               :|.::|:                          .||||..:| |.|.|....|:....|..|
Mosquito  1897 ---VEVEEDE--------------------------QDDDIIVIV-DEDNSAATDSEGGGGSNRG 1931

  Fly  1935 VGGLVVSGGGGGTAIGGGIAVNGGGVLGNGVGSE 1968
            .|     ||||.|   |.:.:.||....||:..|
Mosquito  1932 CG-----GGGGAT---GNVGLVGGVGGTNGISDE 1957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	51/80 (64%)
		fn3	220..304	CDD:278470	80/83 (96%)
		fn3	315..391	CDD:278470	48/76 (63%)
		FN3	405..494	CDD:238020	59/88 (67%)
		FN3	511..574	CDD:238020	46/62 (74%)
		FN3	583..671	CDD:238020	71/87 (82%)
		fn3	683..753	CDD:278470	40/69 (58%)
		fn3	787..850	CDD:278470	54/62 (87%)
		fn3	866..935	CDD:278470	42/68 (62%)
		fn3	961..1043	CDD:278470	44/81 (54%)
		PTPc	1272..1525	CDD:214550	229/252 (91%)
		PTPc	1298..1525	CDD:238006	204/226 (90%)
AgaP_AGAP004246	XP_003436753.1	FN3	89..170	CDD:214495	52/81 (64%)
		fn3	185..269	CDD:278470	80/83 (96%)
		fn3	280..357	CDD:278470	48/76 (63%)
		FN3	371..451	CDD:214495	51/79 (65%)
		fn3	477..541	CDD:278470	47/63 (75%)
		FN3	549..637	CDD:238020	71/87 (82%)
		fn3	649..717	CDD:278470	40/69 (58%)
		fn3	751..817	CDD:278470	56/65 (86%)
		fn3	827..897	CDD:278470	42/69 (61%)
		fn3	929..1005	CDD:278470	43/76 (57%)
		PTPc	1232..1485	CDD:214550	229/252 (91%)
		PTPc	1258..1485	CDD:238006	204/226 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	457	1.000	Domainoid score	I1557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2125
Inparanoid	1	1.050	2355	1.000	Inparanoid score	I114
OMA	1	1.010	-	-		QHG28083
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm50589
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4185
TreeFam	0	0.000	Not matched by this tool.
	10	10.170