DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptp10D and AgaP_AGAP010884

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_309810.4 Gene:AgaP_AGAP010884 / 1271065 VectorBaseID:AGAP010884 Length:1951 Species:Anopheles gambiae


Alignment Length:1840 Identity:354/1840 - (19%)
Similarity:574/1840 - (31%) Gaps:697/1840 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 KELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIY-- 246
            |::|....|||..|...:| :.|::.  |.|:..:..|                      |:|  
Mosquito   448 KKITNSERYQVGQYVTVNG-DVVSHL--NITSIHSNDG----------------------GLYKC 487

  Fly   247 -THYKVSIEPPDANDSVL---YV---EKEGEPPGPAQAAFKGLV---PGRAYNISVQTMSEDEIS 301
             ...||.:....|..:|.   ||   ||:      |..|.:.|:   |...|.|.......|...
Mosquito   488 MASSKVGVAEHSAKLNVYGLPYVRTMEKK------AIVAGETLIVTCPVAGYPIESIVWERDNRQ 546

  Fly   302 LPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPV 366
            ||...:.:..|    |.|...:.:..||.:..:..   :::..:...:..|...|..||.|..| 
Mosquito   547 LPINRKQKVFP----NGTLIIENVERNSDQATYTC---VAKNSEGYTARGTLEVQVMVPPSITP- 603

  Fly   367 AFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNT--MIITWEAD 429
             ||...:....|:         |..|......||.   ||.:|...:.|...||.  :||...::
Mosquito   604 -FFFGEEPLNSGE---------STAVNCMVFKGDA---PLEIRWYMNGNQLPTNENGVIIGRVSE 655

  Fly   430 PASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVT 494
            ..|:.....|.|     ||..|                    |...|:  ::..|:..::..|:.
Mosquito   656 RLSSLSIDPIGY-----FNRGT--------------------YECRVK--NRAGEAFYSAELVIN 693

  Fly   495 RPSSPIIEDL-KSIRMGLN--------------ISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTK 544
            .|...|:|.. |:...|.|              ::||..|.....:|:.|  |:..|.:|.:   
Mosquito   694 VPPRWILEPTDKAFAQGSNAKVECKADGFPKPQVTWKKAVGDTPGEYKDL--RSNDSSIRVE--- 753

  Fly   545 ESRLVIKNLQ-PGAGYEL--KVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPP 606
            |..|.|:|:| ...||.|  .:..:...|.:                :|:.||:        :||
Mosquito   754 EGSLFIQNIQKSNEGYYLCEAINGIGSGLSA----------------VTLITVQ--------APP 794

  Fly   607 ESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEK--------------------YTIQ 651
               ||.| .:|.:|....:    |||...||      ||||                    |||:
Mosquito   795 ---EFVE-KLRNQTARRGE----PSVLQCEA------KGEKPIGILWNMNNIRLDPKSDNRYTIR 845

  Fly   652 ---------------------------VNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVD--SRN 687
                                       :.|.:||.:......:...||..|.:  ::::|  .|.
Mosquito   846 EEILPNGVTSSLSIKRTERSDSALFTCMATNAFGSDDTSINMIIQEVPEMPYA--LKVLDKSGRT 908

  Fly   688 ITLEWPKP-EGR--VESYILKW------WPSD----------NPGRVQ------TKN---VSENK 724
            :.|.|.|| :|.  ::.||:::      |.:|          |..:||      |.|   |:||:
Mosquito   909 VQLSWAKPYDGNSPLKRYIIEFKRSRGSWENDIDRVIVPGDTNEAQVQKLSPATTYNIRIVAENE 973

  Fly   725 --SADDLSTVRVLIGELMP-GVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVV-VANGEKEDE 785
              .:|....|.::..|..| |......::..:...|.......||..  ...|:: ...|.|:..
Mosquito   974 IGVSDPSDVVTIITAEEAPSGKPQAIKVEAINQATLRVSWKAPPRAE--WNGDILGYYVGYKQTS 1036

  Fly   786 RDTI----TLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWT 846
            .:|:    |::|:|......:..:        ||.:.:          |:|      .|:|.:..
Mosquito  1037 LNTLYVYETVNYSPEGGEGKEHSL--------EINNLK----------TYT------QYSIVIQA 1077

  Fly   847 VSGGVASLPIQRQDRLY------PEPITQLHATNITDTEISLRWDLP-----KGEYNDFDIAYLT 900
            .: .|.:.|:..:::.|      .:|.:....|.:|...|.:.|..|     .|....:.:.|..
Mosquito  1078 FN-KVGAGPMSDEEKQYTAEGTPDQPPSDTMCTTLTSQTIRVSWVSPPLESANGVIKGYKVVYAP 1141

  Fly   901 ADNLLAQN-------MTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVP 958
            :|  |..|       .|..::..:..|:.:.|||..|:..:.....|  .|:|:...  |.:.||
Mosquito  1142 SD--LWNNDKNKDYKKTASSDTVLHGLKKYTNYTMQVLATTSGGDGV--RSAPIHCQ--TEQDVP 1200

  Fly   959 GRVERFHPTDVQ-----PSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFES------ 1012
            ..     ||.|:     ...|...|. |.::.||:|.|:::       ...:|.|:.:|      
Mosquito  1201 EA-----PTAVKALVMSEGSIFVSWQ-PPAQPNGLILQYTV-------YIKSGDQEPKSFKVPSY 1252

  Fly  1013 ---EEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTM------------------------ 1050
               .||.|:.||.|    |.|.:.|.|.||.|...:....|                        
Mosquito  1253 QINYEASGLEKNQK----YEFWVTASTTIGEGQSSKTLSAMPSDKVPAKIASFDDKFTATFKEDA 1313

  Fly  1051 --PILAPPRPATQV---------VPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYT---------- 1094
              |.||...||.::         ||.|..|......: |.|:......|.   ||          
Mosquito  1314 KLPCLAVGSPAPEITWKIKGVEFVPNERIRQLPEGSL-FIKDVIRQDAGD---YTCTAENSIAKD 1374

  Fly  1095 ------IIVA------------------------EDDAKNASGL------EMPSW--LDV----- 1116
                  |::|                        |.|.....|.      |...|  :||     
Mosquito  1375 SITHRLIVLAPPQSPQLTLTATTTDSLSVKLKPHESDTAPLQGYTLHYKPEFGEWETIDVALEAP 1439

  Fly  1117 ----------QSYSVW-LPYQAI----------------DPYYPFENRSVEDFTIGTENCDNH-- 1152
                      ..|.|: ..|.:|                .|..|.::|.:|   :.:.:...|  
Mosquito  1440 KYTIEKLYCGSRYQVYATAYNSIGAGEPSDILNTRTKGSKPLLPEKSRFIE---VSSNSITLHLP 1501

  Fly  1153 --KIGYC--------------------NGPLKSG-----------TTYRVKVRAFTGADKFTDTA 1184
              |.|.|                    :..:|.|           |.|.::|.|...|. ||...
Mosquito  1502 AWKDGGCRMSHFVVEHKKKDQIDWNQISNNVKPGGNFVVLDLEPATWYNLRVTAHNNAG-FTVAE 1565

  Fly  1185 YSF----------------PIQTDQD-------NTSLIVAITVPLTIILVLLVTLLFYKRRRNNC 1226
            |.|                |..|.:|       |.:|:|.:...|.:|::.::.:...:.:.|  
Mosquito  1566 YEFATLTITGGTIAPTRDIPELTAEDTIRIILSNLNLVVPVVAALLVIIIAIIVICILRSKGN-- 1628

  Fly  1227 RKTTKDSRANDNMSLP--DSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCT 1289
              |.||....:....|  .:.:::.||                 |.|     :||.::.      
Mosquito  1629 --TNKDDVVYNQSMGPAGAATLDKRRP-----------------DIR-----DELGYIA------ 1663

  Fly  1290 FADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDD 1354
                    |.||            ||.||   .||:|...:.|     .|..:::..|...:...
Mosquito  1664 --------PPNR------------KLPPV---PGSNYNTCDRV-----KRGTVISHNPSIKSNHT 1700

  Fly  1355 FW---RMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFM 1416
            .|   |..:|...:|...|.|.|             :..|..||.:.:      |.:|.:..|  
Mosquito  1701 TWDPRRPLYEELKKAPPPLPRRF-------------NHPPACYGKVVL------HCSDCMEDE-- 1744

  Fly  1417 LCRGSEQRIL---------RHFHFTTWP---DFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCS 1469
            :|..:...:|         :..:|.|:|   ..|.|....|:...:        |.|.|..||  
Mosquito  1745 ICPYATFHLLGFREEMDPTKAMNFQTFPHQNGMGGPGHMGTMGSSM--------AMQVPSHVH-- 1799

  Fly  1470 AGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENI 1534
               .|||:                       .:|.::..:..:..|             .|:.:|
Mosquito  1800 ---SRSGS-----------------------QSMPRQNRYARKNSQ-------------GGQSSI 1825

  Fly  1535 VGPAREMHD-----NEGYEGQQVQLDENGDVVATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQ 1594
            ..||.|..|     .|....:..:::..|.            .|........||.......||| 
Mosquito  1826 YTPAPEYDDPANCAEEDQYRRYTRINSQGG------------SLYCGPGPEYDDPANCAPEDDQ- 1877

  Fly  1595 PLTSSFTGHHTHMPPTTSMSSFGGGGG-GHTNVDAPD------RXHSVVNQSDNNNSVVIVLVDN 1652
             ..|.:.|::     .|....:|..|. |..:|.:|:      |.|...|.|.|         |:
Mosquito  1878 -YGSQYGGNY-----GTPYEHYGSRGSVGRRSVGSPEPPPPPPRNHDTSNSSFN---------DS 1927

  Fly  1653 KPSSMI----CKDSKG--GN 1666
            |.|:.|    |....|  ||
Mosquito  1928 KESNEISEAECDRDNGPRGN 1947

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 7/20 (35%)
fn3 220..304 CDD:278470 19/95 (20%)
fn3 315..391 CDD:278470 14/75 (19%)
FN3 405..494 CDD:238020 18/90 (20%)
FN3 511..574 CDD:238020 18/79 (23%)
FN3 583..671 CDD:238020 25/134 (19%)
fn3 683..753 CDD:278470 24/102 (24%)
fn3 787..850 CDD:278470 10/66 (15%)
fn3 866..935 CDD:278470 17/80 (21%)
fn3 961..1043 CDD:278470 26/95 (27%)
PTPc 1272..1525 CDD:214550 46/267 (17%)
PTPc 1298..1525 CDD:238006 44/241 (18%)
AgaP_AGAP010884XP_309810.4 Ig 16..110 CDD:299845
IG_like 35..106 CDD:214653
I-set 231..320 CDD:254352
Ig 248..317 CDD:143165
I-set 328..402 CDD:254352
IGc2 338..390 CDD:197706
IG_like 417..504 CDD:214653 16/80 (20%)
IGc2 423..494 CDD:197706 14/70 (20%)
I-set 510..593 CDD:254352 18/95 (19%)
IGc2 521..584 CDD:197706 12/69 (17%)
Ig 619..689 CDD:143165 20/99 (20%)
I-set 696..788 CDD:254352 23/112 (21%)
Ig 715..788 CDD:299845 18/93 (19%)
I-set 794..889 CDD:254352 21/108 (19%)
Ig 808..896 CDD:299845 17/97 (18%)
FN3 893..987 CDD:238020 23/95 (24%)
FN3 994..1094 CDD:238020 19/126 (15%)
FN3 1102..1195 CDD:238020 20/98 (20%)
FN3 1200..1288 CDD:238020 27/104 (26%)
Ig 1315..1382 CDD:299845 14/70 (20%)
FN3 1386..1475 CDD:238020 11/88 (13%)
FN3 1480..1560 CDD:238020 14/82 (17%)
Dscam_C 1858..1949 CDD:289151 26/106 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.