DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptpn12

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_476456.2	Gene:	Ptpn12 / 117255	RGDID:	620894	Length:	766	Species:	Rattus norvegicus

Alignment Length:	817	Identity:	197/817 - (24%)
Similarity:	298/817 - (36%)	Gaps:	223/817 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1253 LIKNFAEHYRLMSA---DSDFRFSEEFEELKHVG------RDQPCTFADLPCNRPKNRFTNILPY 1308
            :::.|.:..:.|.:   :.:..|:.:|..|:.:.      :..|....:...|..|||:.:|||:
  Rat     6 ILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPF 70

  Fly  1309 DHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRC 1373
            ||||.||......:.|||||||::.|...||.::.|||||.:|..|||||.||.|...|||..|.
  Rat    71 DHSRVKLTLKTPSQDSDYINANFIKGVYGPRAYVATQGPLANTVIDFWRMIWEYNVVIIVMACRE 135

  Fly  1374 FEKGREKCDQYWP---NDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWP 1435
            ||.||:||::|||   .|  |:.:...|:...|:....|:.:...:|...:|.|.|..||:..||
  Rat   136 FEMGRKKCERYWPLYGED--PITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWP 198

  Fly  1436 DFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLD---RILQQINTSDYVDIF 1497
            |..||:...:::..:...|.....|..||.:|||||.||:|....:|   .:|:.....:..::|
  Rat   199 DHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVF 263

  Fly  1498 GIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDEN----G 1558
            .::..||.:|...|||::||..:|:.:..:.|.:..:.    |:|      |.|...|.|    |
  Rat   264 NLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLY----EIH------GAQKITDGNEISTG 318

  Fly  1559 DVVATI--------------------EGHLSHHDLQQAEAEAI--------------------DD 1583
            ::|::|                    ||......||..|...:                    |.
  Rat   319 NMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDS 383

  Fly  1584 EN---AAILH--DDQQPLT---------------SSFTGHHT-------------HMPPTTSMSS 1615
            :.   ..:||  ..:||.|               |.....||             .:|......|
  Rat   384 DRYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKS 448

  Fly  1616 FGGG---GGGHTNVDAPDRXHSVVNQSDNNNSVVIVLVDNKP-------------SSMICKDSKG 1664
            |.|.   ..||. :..... .|||::|            :||             |...|.|...
  Rat   449 FDGNTLLNRGHA-IKIKSASSSVVDKS------------SKPQELSSGDLKVHDVSQNSCADCSA 500

  Fly  1665 GNIDVLESQQQQQQQQQQQP-------NQGGH---------NITTI--SAINGYNTLQHRRKSQL 1711
            .::|......::.|.....|       ::.||         |.|.:  |..|...||:
  Rat   501 SHLDNAPESSEESQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLK------- 558

  Fly  1712 ITFSSSSCDIKNSLSHEYINGSNGSAANGPP--------SSGSGSGSGPGSNRASRANVRLSFAE 1768
             |.||:........||:.....|.|.....|        |..|.|..|......::....:|.|.
  Rat   559 -TVSSTPNSTAEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTAS 622

  Fly  1769 EDV------------MILPQNHSQQSNHQDDEVFTRRRSLLEVEIGVEVGED-GELAPHEMEEDL 1820
            ..|            .:||.:.::|      |:..||.|      |.|...| .|.:|..:.|..
  Rat   623 ATVSPASSTESACTRRVLPMSIARQ------EMAGRRHS------GAEKDADVSEESPPPLPERT 675

  Fly  1821 EE--------------EDEDEELYMHDEFETHIDTKSNNANDDSGGGSYEDSHALHSSLGGSNRN 1871
            .|              |...:|...|.|.|..|  .|.|...|:|     .||....|...|::.
  Rat   676 PESFVLADMPIRSDWHELPSQECSEHRESEGLI--TSGNDKHDAG-----VSHTAACSPTFSDKK 733

  Fly  1872 SLEKDDDDIEVDVISTDVSCYDQLLGSSCNTRNGDDD 1908
            .        |:....|:|:  |...|:.|....|..|
  Rat   734 E--------EITESLTEVT--DIGFGNRCGKPKGPRD 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	94/264 (36%)
		PTPc	1298..1525	CDD:238006	89/232 (38%)
Ptpn12	NP_476456.2	PTPc	28..292	CDD:214550	94/265 (35%)
Ptpn12	NP_476456.2	PTPc	60..292	CDD:238006	89/233 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910