DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptpn6

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_446360.2	Gene:	Ptpn6 / 116689	RGDID:	620660	Length:	597	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	145/467 - (31%)
Similarity:	202/467 - (43%)	Gaps:	104/467 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1141 DFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGA---------DKFTDTAYSFPIQTDQDNT 1196
            ||.:...| |..|.| ...||:   ...:||....|.         |..||....|.....::.:
  Rat   146 DFVLSVLN-DQPKAG-PGSPLR---VTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEAS 205

  Fly  1197 SLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNFAEHY 1261
            ...|.:..|            :|..|.|          |.|   :.:.|:|.|:    |..:|.
  Rat   206 GAFVYLRQP------------YYATRVN----------AAD---IENRVLELNK----KQESED- 240

  Fly  1262 RLMSADSDFRFSEEFEEL--KHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDD-EG 1323
                 .:...|.||||.|  :.|...........|.|:.|||:.||||:||||..||..|.: .|
  Rat   241 -----TAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPG 300

  Fly  1324 SDYINANYV------PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCD 1382
            |||||||||      |..|| :.:|.:||.|.:|.:|||:|.|:.|:|.|||.||..||||.||.
  Rat   301 SDYINANYVKNQLLGPDENS-KTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCV 364

  Fly  1383 QYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFM---LCRGSEQRILRHFHFTTWPDFGVPNPPQ 1444
            .|||.......||...|....:...|::.:....   |..|...|.:.|:.:.:|||.|||:.|.
  Rat   365 PYWPEVGTQRVYGLYSVTNCKEHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPG 429

  Fly  1445 TLVRFVRAFRDRIGAEQR------PIVVHCSAGVGRSGTFITLDRILQQINTSDY---VDIFGIV 1500
            .::.|:    |:|...|.      ||:||||||:||:||.|.:|.:::.::|...   :||...:
  Rat   430 GVLSFL----DQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTI 490

  Fly  1501 YAMRKERVWMVQTEQQYICIHQCLLAVLE-------------GKE----NIVGP----------- 1537
            ..:|.:|..|||||.||..|:..:...:|             |:|    ||..|
  Rat   491 QMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQRGQESEYGNITYPPALRSAHAKAS 555

  Fly  1538 -AREMHDNEGYE 1548
             ....|..|.||
  Rat   556 RTSSKHKEEVYE 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	108/273 (40%)
		PTPc	1298..1525	CDD:238006	99/245 (40%)
Ptpn6	NP_446360.2	SH2_N-SH2_SHP_like	6..103	CDD:198203
		SH2_C-SH2_SHP_like	111..217	CDD:198185	17/87 (20%)
		PTPc-N6	255..520	CDD:350454	102/269 (38%)
		Substrate binding. /evidence=ECO:0000250	455..461		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910