DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptpru

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_017448609.1	Gene:	Ptpru / 116680	RGDID:	620782	Length:	1452	Species:	Rattus norvegicus

Alignment Length:	1378	Identity:	304/1378 - (22%)
Similarity:	491/1378 - (35%)	Gaps:	447/1378 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 FQAVYP---NPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQW--VRLPSVRSTEA 637
            ||...|   .|....|.|......|...:|..:..:|             ||  ||:.....|.|
  Rat    13 FQFCAPETETPAAGCTFEEASDPVVPCEFSQAQYDDF-------------QWEQVRIHPGTRTPA 64

  Fly   638 DI-----------------------TDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPN--PVS 677
            |:                       ..:::.:.:.:|.:...|..:...|..:...|..|  |:.
  Rat    65 DLPHGAYLMVNASQHAPGQRAHIIFQTLSENDTHCVQFSYFLFSRDGHSPGTLGVYVRVNGGPLG 129

  Fly   678 NIIQLVDSRNIT----LEWPKPEGRVESYILKWWPSD--------------------------NP 712
            :.:.     |:|    .:|.:.|..|.::    ||::                          :|
  Rat   130 SAVW-----NMTGSHGRQWHQAELAVSTF----WPNEYQVLFEALISPDHKGYIGLDDILLFSHP 185

  Fly   713 ----------GRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGIL---SGITSLY 764
                      |.|:. |..:|.|...::..|....|       :|.:|..| |:|   :|:..:.
  Rat   186 CAKAPHFSRLGDVEV-NAGQNASFQCMAAGRAAEAE-------RFFLQRQS-GVLVPAAGVRHIS 241

  Fly   765 PR----TMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDT 825
            .|    |.||..    |...|::..|   .:|..|.....|.|         ||:..||..
  Rat   242 HRRFLATFPLAS----VGRSEQDLYR---CVSQAPRGAGVSNF---------AELIVKEPP---- 286

  Fly   826 DRKVTFTGLVP------GRLYNITVWTVSGGVASLPIQRQD---RLYPEPITQLHATNI------ 875
                  |.:.|      |..|.|.....:..:...||.|::   |:...|..::||.|:
  Rat   287 ------TPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVNLQTYKLW 345

  Fly   876 ---TDTE-----------------------------------------------ISLRWDLPKGE 890
               .|||                                               ::|:|: |.|
  Rat   346 HLDPDTEYEISVLLTRPGDGGTGRPGPPLLSRTKCAEPTRAPKGLAFAEIQARQLTLQWE-PLG- 408

  Fly   891 YNDFDIAYLTADNLL-------AQNMTTR---------NEITISDLRPHRNYTFTVVV------R 933
            || ....:..|.:|.       :.|.|.|         :..||.:|.|.||....:::      :
  Rat   409 YN-VTRCHTYAVSLCYHYTLGGSHNQTIRECVKMERGASRYTIKNLLPFRNVHVRLILTNPEGRK 472

  Fly   934 SGTESSVLRSSSPLSASFTTNEAVPGRVE----RFHPTDVQPSEINFEWSLPSSEANGVIRQFSI 994
            .|.|           .:|.|:|.|||.:.    .|.|.:   ..|..:|..| .|.||:|.|:.|
  Rat   473 EGKE-----------VTFQTDEDVPGGIAAESLTFTPLE---DMIFLKWEEP-QEPNGLITQYEI 522

  Fly   995 AYTNINNLTDA----GMQDFESE---EAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPI 1052
            :|.:|.:...|    |.:...|:   |.:.|..||:||.||:|.::|:|:.|||.......|..|
  Rat   523 SYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLQPGTTYLFSVRARTSKGFGQAALTEITTNI 587

  Fly  1053 LAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQ 1117
            .||...... :|:.:..|.:||.:..|.  ...:...:.:|.::|.|:..:...  ..|...|
  Rat   588 SAPSFDYAD-MPSPLGESENTITVLLRP--AQGRGAPISVYQVVVEEERPRRLR--REPGGQD-- 645

  Fly  1118 SYSVWLPYQ-----AIDPYYPFENRS-----VEDFTIGTENCDNHKI-GYCNGPLKSGTTYRVKV 1171
            .:||.|.::     .:..|:..|..:     ...||:|    ||... |:.|.||:....|.:..
  Rat   646 CFSVPLTFETALARGLVHYFGAELAASSLLEAMPFTVG----DNQTYRGFWNPPLEPRKAYLIYF 706

  Fly  1172 RAFTG------------ADKFTDTAYSFPIQTDQ--DNTSLIVAITVPLTIILVLLV--TLLFYK 1220
            :|.:.            |.|........|::..|  :...||:.|......:|:||:  .::..:
  Rat   707 QAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIIIIR 771

  Fly  1221 RRRN-----------NCRKTTKDSR--------ANDNMSLPDSVIEQN----------------- 1249
            :.|:           |..|.|.:.|        |.|......|.::::
  Rat   772 KGRDRYAYSYYPKPVNMAKATVNYRQEKTHMMTAVDRSFTDQSTLQEDERLGLSFMDAPGYSPRG 836

  Fly  1250 -------------------RP----------------ILIKNFAEHYRLMSADSDFRFSEEFE-- 1277
                               ||                :.:.:..:|...|.....:.|.:|:|
  Rat   837 DQRSSGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF 901

  Fly  1278 -----------ELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANY 1331
                       :||. ||.:|                 :..||..|.||.|:..|..:|||:|||
  Rat   902 FEGWDATKKKDKLKS-GRQEP-----------------VSAYDRHRVKLHPMLGDPDADYISANY 948

  Fly  1332 V------PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTV 1390
            :      .|::....||.||||......|||||.|:....::||:::..|.||.||.:|||.|:
  Rat   949 IDIRINRQGYHRSNHFIATQGPKPEMIYDFWRMVWQEQCVSVVMISKLVEVGRVKCSRYWPEDS- 1012

  Fly  1391 PVFYGDIKVQILNDSHYADWVMTEFMLCRG--SEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAF 1453
             ..|||||:.::.....|::|:..|.|.|.  |.:..:|.||||.||:.|||.....|:.|:|..
  Rat  1013 -DMYGDIKITLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRV 1076

  Fly  1454 RDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYI 1518
            :.....:..|:|:|||||.||:|.:|.||.:|........|||:..|..:...||.|:|||:|||
  Rat  1077 KASTPPDAGPVVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYI 1141

  Fly  1519 CIHQCLL-AVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLSHHDLQQAEAEAID 1582
            .||..:| |.|.|:..|  |..|.   :....:.:::|                          .
  Rat  1142 FIHDAILEACLCGETTI--PVNEF---KATYREMIRID--------------------------P 1175

  Fly  1583 DENAAILHDDQQPLTSSFTGHHTHMPP----TTSMSSFGGGGGGHTNVDA--PDR--XHSVVNQS 1639
            ..|::.|.::.|.|.|.       .||    ..|::........:.::|.  |||  ...:.:..
  Rat  1176 QSNSSQLREEFQTLNSV-------TPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISSDG 1233

  Fly  1640 DNNNSVVIVLVDN 1652
            |.||.:...|.|:
  Rat  1234 DPNNYINAALTDS 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	17/115 (15%)
		fn3	683..753	CDD:278470	17/109 (16%)
		fn3	787..850	CDD:278470	13/68 (19%)
		fn3	866..935	CDD:278470	24/146 (16%)
		fn3	961..1043	CDD:278470	30/92 (33%)
		PTPc	1272..1525	CDD:214550	98/273 (36%)
		PTPc	1298..1525	CDD:238006	90/234 (38%)
Ptpru	XP_017448609.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11776
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000