DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and Tnc

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_008761976.1 Gene:Tnc / 116640 RGDID:621057 Length:2202 Species:Rattus norvegicus


Alignment Length:1832 Identity:345/1832 - (18%)
Similarity:648/1832 - (35%) Gaps:442/1832 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 IVWFRNE---TTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPG 285
            :.| .||   |..|:::.|.:..|:...::|   |.|...:.:                :.|.||
  Rat   641 LAW-DNEMRVTEYLIMYTPTHADGLEMQFRV---PGDQTSTTI----------------RELEPG 685

  Fly   286 RAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSV 350
            ..|.|.|..:.|::.|:|.:|:..|....|..:.|..  |...|..|.|: |..|: |:.:::..
  Rat   686 VEYFIHVFAILENKRSIPVSARVATYLPAPEGLKFKS--IKETSVEVEWD-PLDIA-FETWEIIF 746

  Fly   351 ATTRR--QSTVPRS-NEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLR 412
            ....:  :..:.:| ..|...:....:| ||:.:.:.:..|... |..|....||...|...:..
  Rat   747 RNMNKEDEGEITKSLRRPETSYRQTGLA-PGQEYEISLHIVKNN-TRGPGLKKVTTTRLDAPSQI 809

  Fly   413 SINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDTST--LTTDRTRFTLESLLPGRNYSLS 475
            .:.|....|.:||| :.|.:..|...:.| .::...||.:|  ||.:..::::.:|.|...|.:|
  Rat   810 EVRDITDTTALITW-SKPLAEIDSIELSY-GIKDVPGDRTTIDLTHEDNQYSIGNLKPDTEYEVS 872

  Fly   476 VQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRM---GLNISW---KSDVNSKQEQYEVLYSRNG 534
            :.:....|.||......:|...:|  .:|:.:..   .:.:.|   |:|::|.:.:|..: |...
  Rat   873 LISRRVDMASNPAKETFITGLDAP--RNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPI-SGGD 934

  Fly   535 TSDLRTQKTKE--SRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSN 597
            .:::...|:::  ::..:..|:||..|.:.|.||..|...:|.....|...:.||::.:.....:
  Rat   935 HAEIDVPKSQQATTKTTLTGLRPGTEYGVGVSAVKGDKEGDPATINAATEIDAPRDLQVSETTQD 999

  Fly   598 SVLVHWSPPESGEFTEYSIRYRTDSEQQ-WVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVES 661
            |:.:.|..| ..:|..|.:.|...:.|. .::||. .:|...:||:..|::||:.: |...|...
  Rat  1000 SLTLFWKTP-LAKFDRYRLNYSLPTGQSIEIQLPK-DATSHVLTDLEPGQEYTVLL-TAEKGRHK 1061

  Fly   662 PVPQEVNTTVPPNPVSNIIQLVDS--RNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENK 724
            ..|..|..:....|....:.:.::  ..:.|.|...:...|.::           :|.:..::.:
  Rat  1062 SKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDLAYEYFV-----------IQVQEANKVE 1115

  Fly   725 SADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVAN----GE---K 782
            :|.:.:.:..|....:||::.....:.:.||:..|..:      |::.::.....    ||   .
  Rat  1116 TAHNFTVLGNLRTADIPGLKAATPYRVSIYGVARGYKT------PVLSAETFTGKTPSLGEVTVA 1174

  Fly   783 EDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTD----RKVTFTGLVPGRLYNIT 843
            |...|.:.|::|....:.:.|.|   .:.:|::  .:.:.|.|.    |.|...||.....|.||
  Rat  1175 EVGWDALKLNWTAPEGAYTNFFI---QVLEADM--TQTVQNLTVPGGLRSVDLPGLKAATRYYIT 1234

  Fly   844 VWTVSGGVASLPIQRQDRLYPEPITQLHATNITDT---EISLRWDLPKGEYNDFDIAYLTADNL- 904
            |..|:...::.|:..:  :..|.|.||...::|:.   .::|.|......|..|.|....|:|: 
  Rat  1235 VRGVTQDFSTAPLSVE--VLTEEIPQLGGLSVTEVSWDSLTLNWTTDDLAYKHFIIQVQEANNVE 1297

  Fly   905 LAQNMTTRNEITISDL------RPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVER 963
            .|||:|....:.:.|:      .|:|...:.|:  .|..:.:      |||..:|  |....:..
  Rat  1298 AAQNLTVSGSLRVVDIPGLKADTPYRVSIYGVI--QGYRTPM------LSADVST--AKEPEIGN 1352

  Fly   964 FHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETY 1028
            .:.:||.|...|..|    :..:|:...|:|...:.|.|......:....|....|..|.|...:
  Rat  1353 LNISDVTPESFNLSW----TATDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDF 1413

  Fly  1029 VFKIQAKTAIGFGPEREYRQTMPILAPPRPATQ--------VVPTEVYRSSST-------IQIRF 1078
            :..:.     |..|... .:|:...|...|..|        :.|...:.|.:|       |.|..
  Rat  1414 IVYLS-----GIAPSIR-TKTISTTATTEPEPQLGMLIFSNITPDSFHVSWTTQAGLFAKIVINV 1472

  Fly  1079 RKNYFSDQNGQVRMYTIIVAEDDAKNA--SGLEMPSWLDVQ-SYSVWLPYQAIDPYYP------- 1133
            |..:...::.|      |....||:.|  :||...:..||. :.:.|    |.||..|       
  Rat  1473 RDAHSLHESRQ------ITVPGDAQQAHITGLVENTAYDVSVTGTTW----AGDPTRPLTAFVIT 1527

  Fly  1134 -----FENRSVED-----FTI---GTENC---------DNHKIGYCNGPLKSGTTYRVKVRAFTG 1176
                 .||.::.|     ||:   .:||.         |:.|:........|||..::::|..  
  Rat  1528 EALPLLENLTISDTNPYGFTVSWTASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGL-- 1590

  Fly  1177 ADKFTDTAYSFPIQ--TDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNM 1239
               .|...|...:.  |....|..:.|.|:                         |:.....||:
  Rat  1591 ---ITGIGYEVLVSGFTQGHQTKPLRAETI-------------------------TEAEPEVDNL 1627

  Fly  1240 SLPDSVIEQNRPILIKNFAEHYRL-MSADSDF--RFSEEFEELKHVGRDQPCTFADLPCNRPKNR 1301
            .:.|:.            .:.:|| .:||...  .|.....:.|.....|..|   ||.......
  Rat  1628 LVSDAT------------PDGFRLSWTADEGIFDSFVIRIRDTKKQSEPQEIT---LPSPDRTRD 1677

  Fly  1302 FTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRA 1366
            .|.:........:|..:.....|..::|.......||:|.:.:     ...::...:.|.:.:..
  Rat  1678 ITGLREATEYEIELYGISRGRRSQPVSAIATTAMGSPKEIMFS-----DITENAATVSWRAPTAQ 1737

  Fly  1367 IVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHF 1431
            :......:               |||..|...:..::.:              .:|.|::|   .
  Rat  1738 VESFRITY---------------VPVTGGPPSMVTVDGT--------------DTETRLVR---L 1770

  Fly  1432 TTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDI 1496
            |...::.|.      |..::.|.     |..|:          ||:.||.......:.|::..|.
  Rat  1771 TPGVEYHVS------VIAMKGFE-----ESDPV----------SGSLITALDGPSGLLTANITDS 1814

  Fly  1497 FGIVYAMRKERVWM--VQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGD 1559
            ..:.       :|.  :.|...|:.                          .|.|::|.     :
  Rat  1815 EALA-------MWQPAIATVDSYVI--------------------------SYTGERVP-----E 1841

  Fly  1560 VVATIEGH---LSHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSSFGGGGG 1621
            :..|:.|:   ...|||:.|                 ...|.|......|...:|..:.|     
  Rat  1842 ITRTVSGNTVEFELHDLEPA-----------------TEYTLSVFAEKGHQKSSTIATKF----- 1884

  Fly  1622 GHTNVDAPDRXHSVVNQSDNNNSVVIVLVDNKPSSMICKDSKGGNIDVLESQQQQQQQQQQQPNQ 1686
             .|::|:|.. .:...||:.      .|:..:|.    :.|..|.:.|.||.....::....|:.
  Rat  1885 -TTDLDSPRELTATEVQSET------ALLTWRPP----RASVTGYLLVYESVDGTVKEVIVGPDT 1938

  Fly  1687 GGHNITTISAINGY----NTLQHRRKSQLI--TFSS--------SSC-------DIKNSLSHEYI 1730
            ..:::..:|....|    ..|....:|:||  .|::        ..|       |..:.|...||
  Rat  1939 TSYSLADLSPSTHYTARIQALSGSLRSKLIQTIFTTIGLLYPFPRDCSQAMLNGDTTSGLYTIYI 2003

  Fly  1731 NGSNGSAAN---GPPSSGSGSGSGPGSNRASRANVRLSFAEEDVMILPQNHSQQSNHQDDEV--- 1789
            ||....|..   ...|.|.|.                      ::.|.:.:.::..:::.:.   
  Rat  2004 NGDKTQALEVYCDMTSDGGGW----------------------IVFLRRKNGREDFYRNWKAYAA 2046

  Fly  1790 -FTRRRSLLEVEIGVE----VGEDGELAPHEMEEDLEEEDEDEELY-MHDEFETHIDTKSNNAND 1848
             |..||.  |..:|::    :...|:   :|:..||  :|..|..| ::|.|... |.||.....
  Rat  2047 GFGDRRE--EFWLGLDNLSKITAQGQ---YELRVDL--QDHGESAYAVYDRFSVG-DAKSRYKLK 2103

  Fly  1849 DSG-GGSYEDSHALHSSLGGSNRNSLEKDDDDIEVDVISTDVSCYDQLLGS----SCNTRNGDDD 1908
            ..| .|:..||...|:   |.:.::.:||.|       |...:|.....|:    :|:..|    
  Rat  2104 VEGYSGTAGDSMNYHN---GRSFSTYDKDTD-------SAITNCALSYKGAFWYKNCHRVN---- 2154

  Fly  1909 DIATLVGDGDYS 1920
             :....||.::|
  Rat  2155 -LMGRYGDNNHS 2165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470
fn3 220..304 CDD:278470 18/82 (22%)
fn3 315..391 CDD:278470 15/78 (19%)
FN3 405..494 CDD:238020 21/90 (23%)
FN3 511..574 CDD:238020 15/67 (22%)
FN3 583..671 CDD:238020 21/88 (24%)
fn3 683..753 CDD:278470 8/71 (11%)
fn3 787..850 CDD:278470 17/66 (26%)
fn3 866..935 CDD:278470 19/78 (24%)
fn3 961..1043 CDD:278470 15/81 (19%)
PTPc 1272..1525 CDD:214550 36/254 (14%)
PTPc 1298..1525 CDD:238006 30/228 (13%)
TncXP_008761976.1 EGF_2 346..372 CDD:285248
EGF_2 377..403 CDD:285248
EGF_2 408..434 CDD:285248
EGF_2 434..465 CDD:285248
EGF_2 468..496 CDD:285248
EGF_2 504..527 CDD:285248
EGF_2 533..558 CDD:285248
EGF_2 592..620 CDD:285248
FN3 624..710 CDD:238020 20/88 (23%)
fn3 713..793 CDD:278470 16/85 (19%)
FN3 804..891 CDD:238020 20/88 (23%)
fn3 894..976 CDD:278470 17/84 (20%)
fn3 986..1064 CDD:278470 19/80 (24%)
fn3 1075..1154 CDD:278470 12/95 (13%)
fn3 1166..1241 CDD:278470 20/79 (25%)
fn3 1257..1336 CDD:278470 19/80 (24%)
fn3 1348..1417 CDD:278470 14/72 (19%)
fn3 1444..1509 CDD:278470 15/70 (21%)
fn3 1534..1606 CDD:278470 16/76 (21%)
fn3 1622..1702 CDD:278470 16/94 (17%)
FN3 1712..1798 CDD:238020 19/143 (13%)
fn3 1801..1874 CDD:278470 16/127 (13%)
fn3 1889..1961 CDD:278470 15/81 (19%)
Fibrinogen_C 1981..2190 CDD:278572 46/230 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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