DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptprh

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_012822947.2	Gene:	ptprh / 101733801	XenbaseID:	XB-GENE-992810	Length:	1327	Species:	Xenopus tropicalis

Alignment Length:	1566	Identity:	425/1566 - (27%)
Similarity:	655/1566 - (41%)	Gaps:	345/1566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 WLTW----TVTITTAPDPPSNLSVQVRSGKNAIILWSPPT---QGSYTAFKIKVLGLSEASSSYN 169
            :|.|    .|...:.|.|..::|:...:..|..:.|.||.   :.:|| :.|.|.   ..||.:|
Frog    21 FLIWHGGTPVAAQSVPSPVQSVSISNITTTNVTLSWVPPNDTDKDTYT-YSITVY---NGSSPWN 81

  Fly   170 RTFQVNDNTFQHSVKELTPGATYQVQAYTI-YDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTL 233
            ....::..:.|  |..|.||..|....:|: .:|..|....|.:.||.|:......|.....|.:
Frog    82 LPKNISGTSTQ--VTGLMPGVFYTFSVFTVTSNGTMSSQNGSISGTTVPSPVQSVSVSNITTTNV 144

  Fly   234 LVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSED 298
            .:.|.||                  ||    :.|:                ...|:|:|...|..
Frog   145 TLSWVPP------------------ND----INKD----------------TYTYSITVYNGSSP 171

  Fly   299 EISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSN 363
                                               |:.||.||             ..||.....
Frog   172 -----------------------------------WDWPKNIS-------------GTSTQVTGL 188

  Fly   364 EPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEA 428
            .|..|:          ||:|...|.:|.::|...:...|..|.||::: ||::..|..:.::|..
Frog   189 IPGVFY----------TFSVFTVTSNGTMSSQAGSTSGTTVPSPVQSV-SISNIMTTNVTLSWVP 242

  Fly   429 DPASTQDEYR---IVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAV----SKKMESN 486
            .....:|.|.   .||:...::||.|:...|. |:.|  .|:||..|:.||..|    :|..::.
Frog   243 PNDINKDTYTYSITVYNGSTSWNGPTNISGTS-TQVT--GLIPGVYYTFSVFTVTSNGTKSSQAG 304

  Fly   487 ETSIFVVTRP-SSPIIEDLKSIRMGLNISW--KSDVNSKQEQYEVLYSRNGTSDLRTQKT-KESR 547
            .||...|..| .|..|.::  :...:.:||  .:|:|.....|.:..| ||:|.....|. ..:.
Frog   305 STSGTTVPSPVQSVSISNI--MTTNVTLSWVPPNDINKDTYTYSITVS-NGSSPWNGPKNISGTS 366

  Fly   548 LVIKNLQPGAGYELKVFAVSHD--LRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPE--S 608
            .::..|.||..|...||.|:.:  :.|:..:......|.|.:::||.:....::.:.|:||.  :
Frog   367 TLVTGLIPGVYYTFSVFTVTSNGTMSSQNGSTSGTTEPLPAKDLTITSRTMTTLNLSWTPPNDIN 431

  Fly   609 GEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQV------NTVSFGVESPVPQEV 667
            .....|||.....|....:..|. .:..|.:||:..|..|||.|      .|:|.||:|     :
Frog   432 SNTYSYSINLSNGSTTWNITTPK-NANSAQVTDLLPGVTYTISVYTLTSSGTISSGVDS-----I 490

  Fly   668 NTTVPPNPVSNIIQLVDSRN-ITLEWPKPEG-RVESYILKWWPSDNPGRVQTKNVSENKSADDLS 730
            ..|..|:.|:.:..:..:.| :|:.|..|:. ...:|:.....:::.|   :.||:   |:.::|
Frog   491 KGTTRPSLVTTVSIIKQTNNSVTISWTPPQDINQATYMYSINVTNSAG---SWNVN---SSTNVS 549

  Fly   731 TVRVLIGELMPGVQYKFDIQT-TSYGILSGITSLYP---RTMPLIQSDVVVANGEKEDERDTITL 791
            :..||  :|:|||.|.|.:.| ||.|..|...|  |   .|.|.:..||.|    |....|::||
Frog   550 SKEVL--DLLPGVTYTFCVYTVTSDGTKSSDCS--PDSSTTRPTLVKDVTV----KSQTTDSVTL 606

  Fly   792 SYTPTPQSSSKFDIYRF---SLGDAEIRDKEKLANDT--DRKVTFTGLVPGRLYNITVWTVS--G 849
            |:| ||...:|...|..   :.|.....     .|.|  ....|...|:||..|..:|:||:  |
Frog   607 SWT-TPNDINKGSYYYLITTACGTTTCN-----VNSTVNANGATVASLLPGLTYQFSVYTVTSDG 665

  Fly   850 GVASLPIQRQDRLYPEPITQLHATNITDTEISLRW----DLPKGEYNDFDIAYLTADNLLAQNMT 910
            ..:|..........|...|.:....:..|.:|:.|    ||.|..|. :.:.:...:..|.|::|
Frog   666 TNSSAFASTSGTTAPNAPTSVSGNPVNTTALSVNWTPPNDLNKNNYT-YTVFWQRNNESLNQSIT 729

  Fly   911 TRNEITISDLRPHRNYTFTVVVRSGTESSVLRS--SSPLSASFTTNEAVPGRVERFHPTDVQPSE 973
            : |...|..|.....|..:|:       ||:.:  |....|...||..|||   .|....:..|.
Frog   730 S-NTTIIGGLTAGNQYNVSVI-------SVINNVPSVKAVAYLQTNPEVPG---GFKIVTITNSS 783

  Fly   974 INFEWSLPSS------EANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKI 1032
            :|..|::||.      |.|.|        :..:|||    :.|....:.|::..|.||..|...:
Frog   784 VNVSWTIPSGGSFSGIEINAV--------SGTSNLT----KQFTGPSSEGILDGLIPGTAYNLIL 836

  Fly  1033 QAKTAIGFGPEREYRQ----------TMPIL----APPRPATQVVPTEV---YRSSSTIQIRF-- 1078
            ::.::...|......:          :.||:    ..|...|.:..|:|   |:    :::.|
Frog   837 RSFSSYPSGSSGRISRRATTNNIITYSNPIIEKVQLDPNTVTGITCTKVGGGYQ----LKVAFVC 897

  Fly  1079 -RKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDF 1142
             ..:|.|.:         |:|:.:.|.
Frog   898 PSGSYSSIK---------ILADGNEKE-------------------------------------- 915

  Fly  1143 TIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIV-AITVPL 1206
            ||..:||..   |.....|:..|.|.:.|.....:.:.:|....:     .||..:|| :|...|
Frog   916 TIPAQNCSQ---GATVQSLQPATKYIITVETVADSRQVSDFIICY-----TDNVGVIVGSIFGVL 972

  Fly  1207 TIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKN-FAEHYRLMSADSDF 1270
            ..:||:.:...|..|:|...:...|..|.  ||...:.|   ..|.::|: |.::|:...|||||
Frog   973 LFLLVVGLIAYFVLRKRRGSKNPFKKERG--NMQKINIV---RMPSVMKSAFPDYYQRQHADSDF 1032

  Fly  1271 RFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGH 1335
            .|:||:::|.:||.:|....|:|..||.||||||:|||||||.:|..:|.||.||||||||:||:
Frog  1033 GFAEEYQQLSNVGINQSKLAAELSENRSKNRFTNVLPYDHSRVRLNRIDADETSDYINANYMPGY 1097

  Fly  1336 NSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQ 1400
            ||.:|||.:||||.:|..|||||.||:....|||||.|.|.||.||:.|||.|..|..||||.|.
Frog  1098 NSSKEFIASQGPLPNTSADFWRMIWENQVSTIVMLTNCMENGRVKCEHYWPLDYTPCTYGDITVT 1162

  Fly  1401 ILNDSHYADWVMTEFMLCRGSEQ--RILRHFHFTTWPDFGVPNPPQTLVRF---VRAFRDRIGAE 1460
            :.::....||.:.:|.|....:|  :..||||||.|||.|||....|:|.|   ||.:.| :...
Frog  1163 VTSEMILPDWTVRDFTLKHAKQQGNKHARHFHFTVWPDHGVPENTTTIVEFRNLVREYMD-LKRS 1226

  Fly  1461 QRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL 1525
            ..|.||||||||||:||.|.||.::|::.....:.|:..|..||:.|..|||||.||:.:::|:|
Frog  1227 SGPTVVHCSAGVGRTGTLIALDYLIQKMEKEQRIGIYSFVQKMRQNRPLMVQTESQYVFLNKCML 1291

  Fly  1526 AVLEG--KENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLSHHDLQQAEAEAIDDENAAI 1588
            .:::.  .|||            ||.|             |.|.|.:             |||::
Frog  1292 DLIQNPPDENI------------YENQ-------------IGGDLIY-------------ENASV 1318

  Fly  1589 LHDDQQ 1594
            :.|.|:
Frog  1319 VRDYQK 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	21/84 (25%)
		fn3	220..304	CDD:278470	12/83 (14%)
		fn3	315..391	CDD:278470	13/75 (17%)
		FN3	405..494	CDD:238020	27/95 (28%)
		FN3	511..574	CDD:238020	18/67 (27%)
		FN3	583..671	CDD:238020	25/95 (26%)
		fn3	683..753	CDD:278470	19/72 (26%)
		fn3	787..850	CDD:278470	20/69 (29%)
		fn3	866..935	CDD:278470	16/72 (22%)
		fn3	961..1043	CDD:278470	19/87 (22%)
		PTPc	1272..1525	CDD:214550	129/257 (50%)
		PTPc	1298..1525	CDD:238006	118/231 (51%)
ptprh	XP_012822947.2	FN3	36..113	CDD:214495	21/82 (26%)
		FN3	128..205	CDD:214495	26/172 (15%)
		FN3	220..297	CDD:214495	24/80 (30%)
		FN3	312..390	CDD:238020	20/80 (25%)
		fn3	406..481	CDD:394996	19/75 (25%)
		FN3	496..573	CDD:214495	23/84 (27%)
		FN3	588..665	CDD:214495	25/86 (29%)
		FN3	680..757	CDD:238020	19/85 (22%)
		FN3	771..837	CDD:419708	20/80 (25%)
		R-PTPc-H	1062..1294	CDD:350467	118/232 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010