DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptprd

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_017209878.1	Gene:	ptprd / 100330629	-ID:	-	Length:	1944	Species:	Danio rerio

Alignment Length:	1778	Identity:	426/1778 - (23%)
Similarity:	688/1778 - (38%)	Gaps:	434/1778 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SKATTRIRLKRQKAVPQHRWLWSLAFLAAFTLKDV----------RCADLAISIPNNPGLDDGAS 60
            :.||||:.:.|:..:|           |.|...|:          |.|.:..:...||  |...|
Zfish   116 TSATTRLTVLREDQLP-----------AGFPTIDMGPQLKVVERTRTATMLCAASGNP--DPDIS 167

  Fly    61 YRLDYSPPFGYPEPNTT-------IASREIGD-------EIQFSRALPGTKYNFWLYYTNFTHHD 111
            :..|:.|      .||:       :.|...|.       :|:.|......||.     ...|::|
Zfish   168 WFKDFLP------VNTSNNGRIKQLRSESFGGTPIRGALQIEQSEESDQGKYE-----CVATNND 221

  Fly   112 WLTWTVTITTAPDPPSNLSV-QVRSGKNAIILWS-PPTQ----------------GSYTAFKIKV 158
            ...::.        |:||.| ::|..:.....:| |||.                ||...:...:
Zfish   222 GTRYSA--------PANLYVRELREVRRVPPRFSIPPTDNEIMPGGSVNITCVAVGSPMPYVKWM 278

  Fly   159 LGLSEASSSYNRTFQVNDNTFQHSVKELT---PGATYQVQAYTIYDGKESVAYTSRNFTTK--PN 218
            ||..:.:..       :|.....:|.|||   ..|.|...|.:.....|:||    ..|.|  |.
Zfish   279 LGSEDLTPE-------DDMPIGRNVLELTDVRQSANYTCVAMSTLGVIEAVA----QITVKALPK 332

  Fly   219 TPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLV 283
            .||...|..|..|::.:.|....|..: ::|.:..:|.::.||.    ||.:.....:.:..||.
Zfish   333 PPGVPQVTERTATSITLTWDSGNPEPV-SYYIIQHKPKNSEDSF----KEIDGVATTRYSVGGLS 392

  Fly   284 PGRAY--------NISVQTMSED-----EISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWE 335
            |...|        ||.....|||     ....|:||. |.|..|.|:.|         :..:.|:
Zfish   393 PYSDYQFRVVAVNNIGRGPPSEDIEAKTAEQAPSTAP-RQVRGRMLSAT---------TAIIHWD 447

  Fly   336 APKGIS-EFDKYQVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATG 399
            .|:..: :...|:|...|...|.......:.|...:|..|  ||.|.|   ||...||.::.:.|
Zfish   448 EPEEANGQITGYRVYYTTDPSQHVNQWEKQIVRTSNFLTI--PGLTPN---KTYYIKVLAFTSVG 507

  Fly   400 D---------VTLRPLPVRNLRSINDDKTNT-MIITWEADPASTQDEYRIVYHELETFNGDTSTL 454
            |         :....:|.:......:.|:.| ::::|. .|..|..:.:|:.:||....||
Zfish   508 DGPLSSDLQIIAKTGVPSQPTDFKGEAKSETSILLSWN-PPTQTGQDNQIIGYELLYKKGD---- 567

  Fly   455 TTDR----------TRFTLESLLPGRNYSLSVQAVSKK---MESNETSIFV-VTRPSSPIIEDLK 505
              |:          |.:.|:.|.|...|...:.|.||.   ..:||.|... .|:||:| .:::|
Zfish   568 --DKEEKRVSFEPTTTYLLKELKPFTTYMFQLAARSKHGIGAYTNEISAETPQTQPSAP-PQEVK 629

  Fly   506 SI---RMGLNISWKSD----VNSKQEQYEVLY--------SRNGTSDLRTQKTKESRLVIKNLQP 555
            ..   ...:.:|||..    .|....:|.:.|        |....||:..:|   ...:::||:.
Zfish   630 CTSHSSTSILVSWKPPPVELQNGIMTKYTIQYAATEGDDTSMRQVSDIPPEK---YHYLLENLEK 691

  Fly   556 GAGYELKVFA----------VSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPP---- 606
            ...|.:.|.|          :...:|:|     :.|...|||.:.:|.|.|.||.|.|..|
Zfish   692 WTEYRVTVNAHTEAGEGPESLPQLIRTE-----EDVPSGPPRKVEVEAVNSTSVKVLWRSPVPSR 751

  Fly   607 ESGEFTEYSIRYRTDSEQQWVRLPSVRSTEAD---------------ITDMTKGEKYTIQV---N 653
            :.|:...|.:.|......:.|..|.::....|               ::|:.....|::.|   .
Zfish   752 QHGQIRGYQVHYVRMVNGEPVGHPVIKDILMDDAQWEYDDSAEHELVLSDLHAETTYSVTVAAYT 816

  Fly   654 TVSFGVESPVPQEVNTT--VPPNPVSNIIQLVDSRNITLEW-PKPE--GRVESYILKWWPSDNPG 713
            |...|..|. |:.|.||  ||..| ..::...:.....|:| |.|.  |.::.|.|::...|
Zfish   817 TKGDGARSK-PKLVTTTGAVPEKP-RLMVSPTNMGTALLQWHPPPNTFGPLQGYRLRFGRKD--- 876

  Fly   714 RVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQT---TSYG--ILSGITSLYPRTMPLIQS 773
             |:...|.|....::..|.:    |:..|..|.|.:..   ..:|  .:..|::  |...|....
Zfish   877 -VEPLTVIEFSERENHYTTK----EIHKGASYTFRLSARNKVGFGEETVKEIST--PEDTPAGYP 934

  Fly   774 DVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRD----KEKLANDTDRKVTFTGL 834
            ..:||   :.....||.:|:.|...:.....:.:::|...:|..    .|......:..||..||
Zfish   935 QGIVA---ESSTTTTIQVSWQPVALAERNGAVVKYALQYKDINSPRSPSELFITAPESTVTLDGL 996

  Fly   835 VPGRLYNITV--WTVSG-GVASLPIQRQDRLYPEPITQ------LHATNITDTEISLRWDLPKGE 890
            .....|:|.:  :|..| |..|..:|    ...:|:.|      .|......|.:.|.|::|: .
Zfish   997 KADTTYDIKMCAFTSKGPGPYSPSVQ----FRTQPVNQAVFAKNFHVRAAMKTSVLLTWEIPE-N 1056

  Fly   891 YN---DFDIAYLTADNLLAQNMTTRNEIT---ISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSA 949
            ||   .|.|.|   ||  .|::....::|   |.:|:|...|:|.:..|..:...:....|.::|
Zfish  1057 YNPAQPFTILY---DN--GQSVEVDGKLTQKLIVNLQPETQYSFLLTNRGNSAGGLQHRVSTMTA 1116

  Fly   950 SFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDA---GMQDFE 1011
                                 |..:.             .:.|.|:.||.:.:...   |:|..|
Zfish  1117 ---------------------PDILR-------------TKPFLISKTNADGMVTVELPGVQTAE 1147

  Fly  1012 SEEAFGVI----KNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSS 1072
            ...|:.::    |..:||:  ..|:...                   |.....:.:..|:.|:|
Zfish  1148 RVRAYYIVVVPLKKQRPGK--FIKLWEN-------------------PDEMNLEELLREINRTS- 1190

  Fly  1073 TIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENR 1137
             :.:|||::                          ||:.            ||.|. .::...|
Zfish  1191 -VSLRFRRH--------------------------LELK------------PYIAA-CFHELPN- 1214

  Fly  1138 SVEDFTIGTENCDNHKIG-YCNGPLKSGTTYRVKVRA--------FTGADKFTDTAY-----SFP 1188
               :||:|    |....| :.|..|.:|..|...|.|        ...|..::|...     ..|
Zfish  1215 ---EFTLG----DAKMYGEFQNKQLLNGQEYVFFVLAVLEISDSMLYAASPYSDPVVFADIDPQP 1272

  Fly  1189 IQTDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRAND---------------- 1237
            |..:::....:|...:.:..|:.:::.:|.||..:.:.::...::|...
Zfish  1273 IIDEEEGLIWVVGPVLAVIFIICIVIAILLYKSSQPDRKRAESEARKGSLPSGKEMPSHHPTDPV 1337

  Fly  1238 -----NMSLPDSV------------IEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRD 1285
                 |...|.|.            :..:.||.:...|:|...:.|:.:.:||:|:|.: ..|:.
Zfish  1338 ELRRLNFQTPGSATSVYPSNLHLSRMASHPPIPVMELADHIERLKANDNLKFSQEYESI-DPGQQ 1401

  Fly  1286 QPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHS 1350
            .....::|..|:||||:.|::.|||||..|..:|...||||||:||:.|:.....:|.|||.|..
Zfish  1402 FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIDGIPGSDYINSNYIDGYRKQNAYIATQGALPE 1466

  Fly  1351 TRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEF 1415
            |..|||||.||..|..|||:||..|:.|.||||||||..... ||.|:|.:|:....|.:.:..|
Zfish  1467 TFGDFWRMIWEQRSANIVMMTRLEERSRVKCDQYWPNRGTET-YGLIQVTLLDTVELATYCVRTF 1530

  Fly  1416 MLCR--GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTF 1478
            .|.:  .||:|.:|.|.||.|||.|||..|...:.|:|..:.....:..|:||||||||||:|.|
Zfish  1531 ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKSCNPPDAGPMVVHCSAGVGRTGCF 1595

  Fly  1479 ITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEGKENIVGPAREMH 1542
            |.:|.:|::|.....|||:|.|..||.:|.:|||||.||:.||..|. ||..|...:  |||.::
Zfish  1596 IVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYVFIHDSLQEAVNCGTTEV--PARNLY 1658

  Fly  1543 DNEGYEGQQVQLDENGDVVATIE 1565
               .|..:..|: |:|:.|..:|
Zfish  1659 ---AYIQKLTQI-ESGENVTGME 1677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	21/101 (21%)
		fn3	220..304	CDD:278470	22/96 (23%)
		fn3	315..391	CDD:278470	17/76 (22%)
		FN3	405..494	CDD:238020	23/103 (22%)
		FN3	511..574	CDD:238020	16/84 (19%)
		FN3	583..671	CDD:238020	27/111 (24%)
		fn3	683..753	CDD:278470	16/75 (21%)
		fn3	787..850	CDD:278470	15/69 (22%)
		fn3	866..935	CDD:278470	22/80 (28%)
		fn3	961..1043	CDD:278470	13/88 (15%)
		PTPc	1272..1525	CDD:214550	115/254 (45%)
		PTPc	1298..1525	CDD:238006	108/228 (47%)
ptprd	XP_017209878.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910