DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and ptprb

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:NP_001303656.1 Gene:ptprb / 100149130 ZFINID:ZDB-GENE-101108-3 Length:1892 Species:Danio rerio


Alignment Length:1867 Identity:483/1867 - (25%)
Similarity:749/1867 - (40%) Gaps:457/1867 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 TLKDVRCADLAISIPNNPGL-------DDGASYRLDYSPPFGYPEP---------------NTTI 78
            ||.:.:.:..|:::...|..       .|..|..:.:.|..|..|.               |:|:
Zfish    96 TLDEKQQSQRAVTLQTRPSAVENLQVSGDANSLDVSWQPGKGKTERYWIVLIDSSGRDSAWNSTV 160

  Fly    79 ASREIGDEIQFSRALPGTKYNFWLYYTNFTHHDWL--TWTVTITTAPDPPSNLSVQVRSGKNAI- 140
            ||  ..........:.|..||.    |..|....|  :.:....|||...|.|..:....:|:| 
Zfish   161 AS--TATSYTMKGLISGRLYNI----TVVTEVGELQNSASTQAQTAPASVSKLRTENNGDRNSIR 219

  Fly   141 ILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDN--TFQHSVKELTPGATYQVQAYTIYDGK 203
            :||. ...|...::.:.:  .:..|:|..:....:|.  .|::    |:||..|||...|     
Zfish   220 VLWD-KASGDVDSYLVSL--TTPGSNSIEKVLPPDDTYVVFEN----LSPGKGYQVSVST----- 272

  Fly   204 ESVAYTSRNFTTKPNTPGK----FIVWFRNETTLLVLWQPPYPAGIYTHYK-------------- 250
            .|.|.:::.:.|....|||    .|........|.:.|.|  |:|.:.|.:              
Zfish   273 RSGALSNKTWITGKADPGKVSDLVIENLSVRGALKISWTP--PSGEWEHIRVALSNGSEVLRNQT 335

  Fly   251 ------------------------VSIEPPDANDSVLYVEKEGEPPGP----------------A 275
                                    ||:|.....::|:|..:.|.||..                |
Zfish   336 VGRTAKEILLSGLNLLPGRVYRMAVSVENGGLANTVIYEGEIGLPPVSQLHVRHSDETSLSALWA 400

  Fly   276 QAA----------------------------------FKGLVPGRAYNISVQTMSEDEISLPTTA 306
            .||                                  |..|.|||.|:|:|.|.:: .|....|.
Zfish   401 HAASSSSRDGYIIQLFQSNTSTVIQTRNLSRDMRECTFNVLTPGRLYDITVTTTAK-IIRSSATL 464

  Fly   307 QYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTV----PRSNEPVA 367
            |.||.||:..::.......| :|....||.|.|  :.|.|.:.:  .|.|.||    ..:|....
Zfish   465 QGRTQPLKVNHLKLSNKGST-DSLNASWEKPLG--DLDFYHMLL--LRDQQTVHNITASANTTSR 524

  Fly   368 FFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPAS 432
            ...|   ..||....::|.|:||..||..|..:....|..|.:: ::.:...:.:.::|:|....
Zfish   525 LLPF---LRPGALHKILVTTISGSQTSKLAEAECRTVPAAVSDI-TVTNSGPDFLNVSWKAAEGD 585

  Fly   433 TQDEYRIVYHELETFNGDTSTLTTDR--TRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTR 495
            . |.|.::..:.|..   ..||.|.:  |.....||:.||.||:|: |.......|:|.:...|:
Zfish   586 V-DNYVVMLKDQEKI---VHTLATSKATTECVFRSLVSGRLYSISI-ATHSGSYRNQTLLQERTK 645

  Fly   496 PSSPIIEDLKSIRMG----LNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTK--ESRLVIKNLQ 554
            ||:  :::..:|...    |.:.| :..:...:.|.|....|||. |::||..  :|.....:|.
Zfish   646 PST--VQNPTAIHSARDDFLKLYW-NHASGDYDYYVVTIEHNGTR-LQSQKLNRTQSDCAFSDLV 706

  Fly   555 PGAGYELKV--------FAVSHDLRSEPHA----------------------------------- 576
            ||..|.|.|        .|||...|:.|.|                                   
Zfish   707 PGRLYNLTVSTWSGQHYSAVSIYGRTFPGAVGNLSLTERGGTFLRVSWTSAPGDVDHYELQILFN 771

  Fly   577 -----------------YFQAVYPNPPRNMTIET-------------------VRS--------- 596
                             .|.|:.|.....:.:.|                   |:|         
Zfish   772 DTQVSAAVNLSSAIGEHLFSALTPGRLYKIVLSTHSGSYQRAEILEGRTVPSQVQSVHLSAGTAD 836

  Fly   597 NSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVES 661
            .|:.|.||..: |:...||:....::..|..|......|:|:..::..|:.|::.|.:||..   
Zfish   837 GSLRVSWSSAD-GDLDFYSVSLFQETHLQDSRRVPKHITQAEFYNLIPGQLYSVTVQSVSGS--- 897

  Fly   662 PVPQEVNTT----VPPNPVSNI--IQLVDSRNITLEWPKPEGRVESYILKWWPSD---------- 710
               |..|:|    ..|:.|:.:  ...:.:.::.:.|....|..:.|.| |...|          
Zfish   898 ---QTNNSTTTGRTEPSTVTGLRADNELSTHSLLVSWNPAVGVHDGYRL-WLLDDGGTNIHNASV 958

  Fly   711 ------------NPGR----------------------------VQTKNVSENKSA--------- 726
                        .|||                            |...:|..|.|:         
Zfish   959 PAASRHHLFENLTPGRRYQAHVRTLSGTAESKDVVAEGQTRPSAVSALHVCSNTSSDLSFCWASA 1023

  Fly   727 --------------DDLSTVRVLIGE---------LMPGVQYKFDIQTTSYGILSGITSLYPRTM 768
                          |:.......:|.         |.||..||..| |:..|.||..:|::..|.
Zfish  1024 VGWVDGYELYLYDRDETLHYHTTLGSDALGWSFTLLQPGTHYKMTI-TSKSGKLSNQSSVWAHTA 1087

  Fly   769 PLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTG 833
            |   :.|...:.|.:.:.|::.||:||.|...:.:.:        .:..:|:.......:|.|..
Zfish  1088 P---ASVPELHVENQGQTDSLLLSWTPAPGGLTGYSV--------TVDGREQRVGPEVTQVVFHS 1141

  Fly   834 LVPGRLYNITV--WTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLP-KGEYNDFD 895
            ||.||||..||  |:.....::..:.|.....|..:    :.:.:...:.::|.:| .|:|.||:
Zfish  1142 LVAGRLYLATVQTWSEDLSNSTTAVGRTVPAAPSSV----SVSCSGGSVDMKWHVPDTGDYEDFE 1202

  Fly   896 IAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGR 960
            :.:...|.|...::.....| :..|.|.|.|..::...||...|.:..|.|:   :.|....|..
Zfish  1203 VTWFPQDTLYISHLRPTQRI-LEGLHPGRLYNISLRTVSGKRHSPVTYSRPV---YHTIRTPPLP 1263

  Fly   961 VERFHPTDVQPSEINFEWSLPSSEANGVI----RQFS--IAYTN-INNLTDAGMQDFESEEAFGV 1018
            ....|...:..:.::..|:.|.|:.:|.:    ||.|  ..||: :.|.|.:  |.|:       
Zfish  1264 APSIHCFPLSSTSVSCSWTPPHSDYDGFVVQCHRQGSGKAVYTHTLGNHTLS--QQFD------- 1319

  Fly  1019 IKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILA----PPRPATQVVPTE--VYRSSSTIQIR 1077
              .|:|.:.|...:    |:..|.::.......::.    ||.|...|...|  ...:..||:.:
Zfish  1320 --RLEPFKNYTIYV----AVMSGDKQSSTVKNSVITMIDRPPVPPVTVRVNEHSAVITHFTIRFK 1378

  Fly  1078 FRKNYFSDQNGQVRMYTIIVAE-DDAKNASGL-----EMPSWLDV-QSYSVWLPYQAIDPYY--- 1132
            |..::|||.||.:|.:|||..| :|..|  ||     .:||:||. |::|: ..||.  .|:   
Zfish  1379 FNCSWFSDANGAIRYFTIIATESNDVDN--GLPEQRHPLPSYLDYRQNHSI-KAYQT--GYFHST 1438

  Fly  1133 --PFENRSVEDFTI----------GTENCDNHKIGY----CNGPLKSGTTYRVKVRAFTGA-DK- 1179
              ...:..|:.|.|          |....|...|.:    |:|||:|.|:||:.|||||.. |: 
Zfish  1439 CAEGSDGKVQVFEINLGAGMKHLGGACKLDPESIQHGSHLCDGPLRSRTSYRLSVRAFTQLFDEE 1503

  Fly  1180 --------FTDTAYSFPIQTDQ-DNTSLIVAITVPL---TIILVLLVTLLFYKRRRNNCRKTTKD 1232
                    :|||..|.|:.|.. ..:.|...||..|   |::|.|...|::.||......:.:..
Zfish  1504 NREFPHPLYTDTYLSLPLLTQSAPRSGLTGGITAALFLITMVLALTALLIYRKRAHKIAVQESPV 1568

  Fly  1233 SRANDNMSLPDS--VIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPC 1295
            .:.....:||.|  .:....|:...||..|...:.:||.:..|||||.||.|||.|....|.|..
Zfish  1569 MKMCKWKALPTSQMCLRIRSPVQAANFESHLAKLQSDSSYLLSEEFEGLKDVGRIQTQNAARLLG 1633

  Fly  1296 NRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCW 1360
            ||.|||:.||||||.:|.:|..::||..||||||||:||:|...|:|.|||||..|:||||||.|
Zfish  1634 NRNKNRYNNILPYDSTRVRLSCLEDDPCSDYINANYIPGNNFRWEYIATQGPLPGTKDDFWRMVW 1698

  Fly  1361 ESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSE--- 1422
            |.|..::||:|:|.|:|..|||.|||.|:.|:.||||.||:|::..:.:|.:.:|.:...|:   
Zfish  1699 EQNVHSLVMVTQCVERGMVKCDHYWPTDSEPLCYGDIVVQLLSEKVFPEWTIRDFKISCESQLRY 1763

  Fly  1423 QRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRP--IVVHCSAGVGRSGTFITLDRIL 1485
            .|::|.||:|.|||.|||:..|:|::|||..||.|.....|  .||||||||||:||||.|||.|
Zfish  1764 PRMVRQFHYTIWPDHGVPDTTQSLIQFVRTVRDFINRTNSPGISVVHCSAGVGRTGTFIVLDRAL 1828

  Fly  1486 QQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE 1532
            ||::.:..|||:|.|:.:|..|.:|||||.||..||||:..||..::
Zfish  1829 QQLDRNCTVDIYGCVFDLRLHRSYMVQTECQYAYIHQCVRDVLRARK 1875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 18/83 (22%)
fn3 220..304 CDD:278470 31/175 (18%)
fn3 315..391 CDD:278470 19/79 (24%)
FN3 405..494 CDD:238020 21/90 (23%)
FN3 511..574 CDD:238020 21/72 (29%)
FN3 583..671 CDD:238020 23/119 (19%)
fn3 683..753 CDD:278470 22/151 (15%)
fn3 787..850 CDD:278470 18/64 (28%)
fn3 866..935 CDD:278470 13/69 (19%)
fn3 961..1043 CDD:278470 19/88 (22%)
PTPc 1272..1525 CDD:214550 138/257 (54%)
PTPc 1298..1525 CDD:238006 123/231 (53%)
ptprbNP_001303656.1 FN3 113..199 CDD:238020 16/91 (18%)
fn3 216..276 CDD:306538 17/71 (24%)
FN3 290..366 CDD:328772 12/77 (16%)
fn3 380..453 CDD:306538 13/72 (18%)
fn3 561..632 CDD:306538 18/76 (24%)
FN3 647..727 CDD:328772 20/83 (24%)
fn3 735..808 CDD:306538 5/72 (7%)
fn3 823..896 CDD:306538 17/73 (23%)
fn3 911..990 CDD:306538 10/79 (13%)
FN3 1001..1081 CDD:328772 16/80 (20%)
fn3 1090..1154 CDD:306538 19/71 (27%)
FN3 <1190..1246 CDD:328772 15/56 (27%)
fn3 1263..1340 CDD:306538 19/91 (21%)
PTPc 1637..1867 CDD:238006 122/229 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 265 1.000 Domainoid score I1858
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2125
Inparanoid 1 1.050 446 1.000 Inparanoid score I1609
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D16347at33208
OrthoFinder 1 1.000 - - FOG0001181
OrthoInspector 1 1.000 - - otm25697
orthoMCL 1 0.900 - - OOG6_106915
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4185
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.870

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