DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and ptpn21

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_012823384.2 Gene:ptpn21 / 100127697 XenbaseID:XB-GENE-960393 Length:1218 Species:Xenopus tropicalis


Alignment Length:1287 Identity:266/1287 - (20%)
Similarity:444/1287 - (34%) Gaps:409/1287 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   414 INDDKT------NTMIITWEADPASTQDEYRIVYHELETFN--GDTSTLTTDR--TRFTLESLLP 468
            |.|:||      |..::..:....|..|...:...|:|...  ||.|....|.  |...:.:.|.
 Frog   175 IQDEKTLEEATKNVALLHQKLRGLSPPDAELLYMQEIEKLENYGDESYPAKDSQGTDLCIGACLS 239

  Fly   469 GRNYSLSVQAVSKKMESNETSIFVVTRPSSP--IIEDLKSIRMGLNISWKS-DVNSKQE--QYEV 528
            |                    |||..:...|  :...|....|..|.|:.: ::.:|:|  |:: 
 Frog   240 G--------------------IFVKHKNGRPPIVFRWLDIANMSHNKSFFTLELANKEETIQFQ- 283

  Fly   529 LYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPP-----RN 588
                  |.|:.|.|......|.::         |.:.::.:|.| |.:      |.||     ::
 Frog   284 ------TEDMETAKYVWRMCVARH---------KFYRLNGNLDS-PES------PPPPMEGFQKS 326

  Fly   589 MTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVN 653
            ..:.:::...:|...|.|:....|...:|.|:.:.   |.||             |.:.|.:   
 Frog   327 PFLLSLQRFPILSRPSIPKGQSQTVNPVRRRSSTR---VSLP-------------KHQPYMM--- 372

  Fly   654 TVSFGVESPVPQEVNTTVPPNPVS--NIIQLVDSRNITLEWPKPEGRVESYI------LKWWPSD 710
                   .|.....|....|...|  ||...|.|:|             .|.      |...|.|
 Frog   373 -------PPHQMHYNGHYEPYTSSQDNIPMFVSSQN-------------GYYYHSQTSLDRTPHD 417

  Fly   711 NPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDV 775
            ..||::..:|....|.:.|:|.:          .|......:|...::|...:.|..:|..:...
 Frog   418 YNGRIRNGSVYSAHSTNSLNTQQ----------HYMQPSPMSSNPSITGSDIMRPEYIPSHRHSA 472

  Fly   776 VVANGEKEDERDTITLSYTPTP------------------QSSSKFDI-----YRFSLGDA---- 813
            :            |..||.|||                  ||.|..::     |.:|..||    
 Frog   473 L------------IPPSYRPTPDYETVMRQLSRGMVHSERQSHSMRNLNIGNSYAYSRPDALVYS 525

  Fly   814 --EIRDKEKLAN----------------------DTDRKVTFTGLVPGRLYNITV----WTVSGG 850
              |||:..:.|:                      ..:|:.....:....|.|:.:    :|.| .
 Frog   526 QPEIREHAQFAHPQSNHYPFNLNYSFHSQSPYPYQAERRPVVGAVSVPELTNVQLQVQDYTAS-N 589

  Fly   851 VASLPIQRQDRLYPEP--------ITQLHATNITDTEISLR--WDLPKGEYNDFDIAY------- 898
            :....:.|....||.|        :|:.|.::.....|:.|  ..:...:.:...:|:       
 Frog   590 IMKTQVYRPPPPYPYPRPANSTPDLTRHHISSSNPDLITRRVHHSVQMFQEDSLPVAHSLQEVSE 654

  Fly   899 -LTADNLLAQNMTTRNEITISDLRPH-------RNYTFTVVVRSGTESSVLRSSSPLSASFTTNE 955
             |||..  ...:..||.|.|:.| .|       :..|.:....|||...:|.|.|.......|.|
 Frog   655 PLTAAR--HARLQKRNSIEIAGL-THSFDGLRVKERTISTSAASGTPQRILSSESQTVIMERTKE 716

  Fly   956 AVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGM-------QDFESE 1013
                          :..|        .||..|        |.:..:|:||.|       .|.|:|
 Frog   717 --------------EQGE--------DSERGG--------YGHKKSLSDATMLIHSSEDDDEETE 751

  Fly  1014 EAFGVIKNLKPGETYVFKIQAKTAIGFGP----EREYRQTMPILAPPRPATQVVPTEVYRSSSTI 1074
            |                  ..:|:|...|    ..:.|..|...     :.::.|...|.|:|..
 Frog   752 E------------------DNRTSITQAPLFYDRAQLRTVMETY-----SDELEPNYTYSSASAN 793

  Fly  1075 QIRF---RKNYFSDQNGQVRMYTIIVAEDD---AKNASGLEMPSWLDVQSYSVWLPYQAIDPYYP 1133
            .:..   :|....::..:.::.:.:....|   .:...|...||..:....:|.:.|:....  |
 Frog   794 HLHIYEHKKQEEVEKEMRPKVVSPVQFSGDFQPNRRGEGNIPPSASESDLTAVGIRYRPKKD--P 856

  Fly  1134 FENRSVEDFTIGTENCDNHKIGY-CNGPLKSGTTYR------VKVRAFTGADKFTDTAYSFPIQT 1191
            .:.|.|.:...|.::...   |. .:|.:|.||...      :|:.|:.|               
 Frog   857 VKKRPVSEVLSGKKDIVE---GLPPSGGIKKGTRMEAKKIGPLKMAAWNG--------------- 903

  Fly  1192 DQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKN 1256
                          |::                            ..|.|||.  |:..|....|
 Frog   904 --------------LSL----------------------------SRMPLPDE--EKEEPSRASN 924

  Fly  1257 FAEHYRLMSADSDFRFSEE-------FEELKHVGR----DQPCTFADLPCNRPKNRFTNILPYDH 1310
                      |...:..|:       |.|.:.:.:    |..|:.|.||.|..:||:.::||||.
 Frog   925 ----------DDRCKLLEQRLEQGMVFTEYEQISKKRLPDSECSIARLPENSERNRYQDVLPYDD 979

  Fly  1311 SRFKLQPVDDDEGSDYINANY--VPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRC 1373
            :|.:|.|..:: .:.||||::  |.......::|.||||:.||..|||:|.||.....|.|:|..
 Frog   980 TRVELVPTKEN-NTGYINASHIKVTVGGVEWDYIATQGPIQSTCQDFWQMVWEQGIAIIAMVTLE 1043

  Fly  1374 FEKGREKCDQYWP-----NDTVPVFYGDIKV--QILNDSH-YADWVMTEFMLCRGSEQRILRHFH 1430
            .|.||||..:|||     ::||.  ||..|:  :...||. ||...:....|..|.| |.:.|..
 Frog  1044 EEGGREKSYRYWPRLGSRHNTVN--YGRFKITTRFRTDSGCYATTGLKIKHLLSGQE-RTVWHLQ 1105

  Fly  1431 FTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQR-------------PIVVHCSAGVGRSGTFITLD 1482
            :|.||:.|.|..    |:...::.:.|.:.:|             |::|||||||||:|..:..:
 Frog  1106 YTDWPEHGHPED----VKGFLSYLEEIQSVRRHTNSTIDPNSPNPPVLVHCSAGVGRTGVIVLSE 1166

  Fly  1483 RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENI 1534
            .::..:..::.:||..::..:|.:|:.||||..||..:::.|:..|:....|
 Frog  1167 VMIACLEHNEMLDIPLVLDMLRHQRMLMVQTLSQYTFVYKVLIQFLKSSRLI 1218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470
fn3 220..304 CDD:278470
fn3 315..391 CDD:278470
FN3 405..494 CDD:238020 19/89 (21%)
FN3 511..574 CDD:238020 13/65 (20%)
FN3 583..671 CDD:238020 16/92 (17%)
fn3 683..753 CDD:278470 14/75 (19%)
fn3 787..850 CDD:278470 22/117 (19%)
fn3 866..935 CDD:278470 16/93 (17%)
fn3 961..1043 CDD:278470 16/92 (17%)
PTPc 1272..1525 CDD:214550 90/286 (31%)
PTPc 1298..1525 CDD:238006 81/249 (33%)
ptpn21XP_012823384.2 FERM_F1_PTPN21 20..106 CDD:340712
B41 24..222 CDD:214604 11/46 (24%)
FERM_C_PTPN14_PTPN21 217..307 CDD:270009 24/125 (19%)
PTP_DSP_cys 927..1213 CDD:421693 91/293 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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