DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptprz1

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001362251.1	Gene:	ptprz1 / 100125091	XenbaseID:	XB-GENE-1011831	Length:	2281	Species:	Xenopus tropicalis

Alignment Length:	1817	Identity:	421/1817 - (23%)
Similarity:	660/1817 - (36%)	Gaps:	516/1817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ISIP-NNPGLDDGASYRLDYSPP------FGYPEPNTTIASREIGDEIQFSR--------ALPGT 96
            |.|| .||  ...:::..|.:||      .....|...|.|.:|.|  .||.        ..|.|
Frog   581 ILIPTRNP--KPVSNHTTDTTPPTVSATFVSEITPQGNIVSSDIND--YFSSTSEDIAKVTAPVT 641

  Fly    97 KYNFWLYYTNFTHHDWLTWTVTITTAPDPPSN---------LSVQVRSGKNAIILWSPPTQGSYT 152
            :::.:...|:.:     |..|.:.:....|::         ||..:.||  |.:|.:  |..|..
Frog   642 EFDLYKISTSTS-----TSNVPVVSEEQHPTDSVSLHIDELLSTSLSSG--ATVLQA--TASSLE 697

  Fly   153 AFKIKVLGLSEASSSYNRTFQVND-------NTFQH-----SVKELTPGATYQVQAYTIYDGKES 205
            ......|...|.....|.||...:       .:|.|     ||.|:...||.......:.:|:..
Frog   698 EMNKATLPGKEMLPVSNTTFSTPEALLESVSASFGHHDSESSVSEVLSQATLSQTTQPVSNGEIP 762

  Fly   206 V--AYTSRNF--TTKPNTPGKFIVWFRNETTL------LVLWQPPYPAGIYTHYKVSIEPPDAND 260
            :  ::||..|  .|...:..|.:     :.||      |:|...|    ::....||:||
Frog   763 LQPSFTSEVFPLVTPLLSDNKLL-----KATLATSDIDLILHATP----VFPSVDVSVEP----- 813

  Fly   261 SVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFI 325
            |:.|.:      |....||.........:..:.|:||....:||                  |.:
Frog   814 SLSYYD------GAPLLAFSSASSTSKVSPHLYTVSELFSQVPT------------------DTL 854

  Fly   326 TSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSG 390
            :.::..||.|:...:.....|...|   :...|...::|.:.|      ...|.||....|.:|
Frog   855 SLHASLVLTESNALLQPSHTYYSDV---KPHQTTFGAHETLTF------DHGGDTFKKSNKLIS- 909

  Fly   391 KVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDTSTLT 455
                               :|.|.|.:                     :..|.|.|.:..||.|:
Frog   910 -------------------HLESPNTE---------------------LKMHALSTVSELTSPLS 934

  Fly   456 TDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIF------------VVTRPSSPIIEDL---- 504
            :|.          ..:.|.:|...|.....:...||            |:.|||:..:.|:
Frog   935 SDM----------ASSESFAVSYDSSAFVHDTVGIFHQGTIIKNLGTEVLYRPSTISVPDISFQP 989

  Fly   505 -KSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSH 568
             :||   ||....||..|....|      ||..||:.|:...|...:.:|.....:......:.:
Frog   990 TQSI---LNHEDSSDTFSGSGFY------NGIDDLKVQEVVPSVSAVGDLLKTIEFIENKKVIKN 1045

  Fly   569 DLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPE-----SGEFTEYSIRYRTDS-EQQWV 627
            |...|.:...|||....|            |.:|....|     |.:..:|..:....| |...:
Frog  1046 DHIGESNTGLQAVSAYGP------------VTLHAGNEEVAGLSSSDARDYIFKVEQSSQETPPL 1098

  Fly   628 RLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEW 692
            ...:.||.:|||             |..|   |:.:|.:...|:|          ..|.||:|..
Frog  1099 SFSTPRSFDADI-------------NAAS---ENLLPVKQINTLP----------TTSANISLTD 1137

  Fly   693 PKPEGRVESYILKWWPSDNPG---RVQTKNVSE------NKSADDLSTVRVLIGELMPGVQYKFD 748
            ..||....|.......|....   .|..|.||:      ::|:|...:..|...||:       :
Frog  1138 MLPEASAVSAFSNMLLSPTQELFYEVSDKAVSDFFFQNVSQSSDVSISSNVTHAELL-------N 1195

  Fly   749 IQTTSYGILSGITSLY------PRTMPLIQSDVV--VANGEKEDERDTITL--------SYTPTP 797
            ..:.||.:.|.|.||.      ....||:.|..|  |.|....|..::..|        ::...|
Frog  1196 DASRSYNLSSNIGSLLLPSPSDNSIKPLLHSTYVTPVGNALSPDSVESTVLQQSVLAVHNHYVVP 1260

  Fly   798 QSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRL 862
            ..|:     ..:.|.:.:.||..|..|                                     :
Frog  1261 HLSA-----TVNSGISYVNDKANLTLD-------------------------------------I 1283

  Fly   863 YPEPITQLHA-------TNITDTEISLRWDLPKGEY----------NDFDIAY-----LTADNLL 905
            .|...:.|||       ||....:.:|.::||...|          .:.||:|     :|..:||
Frog  1284 VPSFFSSLHAISTPVLPTNTLTQDTTLNYNLPSYPYATHGTPAASRTNKDISYSLSTDVTVHSLL 1348

  Fly   906 -------------------AQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASF 951
                               ...|.|....|.||:.|      ||...:....||:.....:::::
Frog  1349 LPTVYVSVTAGFPKSESPSTLTMLTATSQTSSDILP------TVSSDAKMGPSVVDDGFIIASTY 1407

  Fly   952 TTNEA-VPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEA 1015
            :|:.. ..|.|...:.:.|....:..:.....||.:.....||.|..: ||: |:.|:
Frog  1408 STSHTETQGNVVADNSSFVHREMLKNKTFSEHSEQSEDGSAFSTAAAD-NNI-DSDME------- 1463

  Fly  1016 FGVIKNLKPGETYVFKIQAKTAIG-----FGPEREYRQTMPILAPPRPATQ---VVPTEVYRSSS 1072
                     ||:|:......::.|     |.....:.||:..|......::   |:..|...|..
Frog  1464 ---------GESYLSTTMPMSSTGQKHIPFTAPETHIQTLNTLLENTSESRSWAVLTDEESGSGP 1519

  Fly  1073 TIQIRFRKN------YFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPY 1131
            :.......|      .|||.|.:.:.|.:.:....|....|.||.|           |.......
Frog  1520 STSDSLSDNETSTDFNFSDINDRDKDYEVAIQPGKADLTPGSEMTS-----------PPSVTSER 1573

  Fly  1132 YPFENRSVEDFTIGTENCDNH--KIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQD 1194
            .|..|.|..|......:..:|  ::|...| |:|                             ::
Frog  1574 SPVVNVSEADVVNQEASNSSHESRVGLAEG-LES-----------------------------EE 1608

  Fly  1195 NTSLIVAITVPLTII-LVLLVTLLFYKRRRNNCRKTT----KDSRANDNMSLPD----SVIEQNR 1250
            .|.:.:.:...||.| ||:||.:|.|.|:   |.:|.    :|:.::..:|.|.    .|.:...
Frog  1609 KTVIPLVVVSSLTFICLVVLVGILIYWRK---CFQTAHFYLEDNASSRVISSPPIPVFPVADDVE 1670

  Fly  1251 PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADL---------PCNRPKNRFTNIL 1306
            .|.:|.|.:|...:.:.:.  |::||||:      |.|| |||         |.|:.|||:.||:
Frog  1671 AIPLKQFPKHVEELHSRNG--FTDEFEEI------QNCT-ADLGITSDNSNHPDNKNKNRYVNIV 1726

  Fly  1307 PYDHSRFKLQPVDDDEG--SDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVM 1369
            .|||||.||..:.:.||  :||||||:|.|:|..:.:|..||||.||.:|||||.||.|...|||
Frog  1727 AYDHSRVKLSQLGEKEGKATDYINANFVDGYNKQKAYIAAQGPLKSTAEDFWRMLWEHNVEVIVM 1791

  Fly  1370 LTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML-----CRGSE-----QR 1424
            :|...||||.|||||||:|.... ||...|...|....|.:.:..|:|     .:||:     :|
Frog  1792 ITNLVEKGRRKCDQYWPSDGSEE-YGSFLVTHKNTKVLAYYTVRTFILRNNKIKKGSQKGRHNER 1855

  Fly  1425 ILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN 1489
            .:..:|:|.|||.|||.....::.|||...........|:||||||||||:||:|.||.:|:||.
Frog  1856 TVVQYHYTQWPDMGVPEYTLPVLTFVRKASATKCNGNGPVVVHCSAGVGRTGTYIVLDSMLKQIQ 1920

  Fly  1490 TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQL 1554
            ....|:|||.:..:|.:|.::||||:|||.||..|:..:..:|..| |...:|   ||....:..
Frog  1921 HEGTVNIFGFLKHIRSQRNYLVQTEEQYIFIHDALVEAILSRETEV-PESHIH---GYVNTLLTT 1981

  Fly  1555 DENGDVVATIEGH---LSHHDLQQAE-AEAIDDEN------AAILHDDQQPLTSSFTGHHTHMPP 1609
            ..:|.  :.:|..   ||..::.|.: :.|:..:|      ::|:     |:..|..|
Frog  1982 GPSGK--SRLETQFKLLSEPNILQCDYSMALKPQNRDKNRTSSII-----PVERSRVG------- 2032

  Fly  1610 TTSMSSFGGGGGGHTNVDAPDRXHS----VVNQS--------------DNNNSVVIVLVDNK 1653
               :||..|.|..:.|.......|.    ::.|.              |:|:.::::|.||:
Frog  2033 ---LSSLAGEGTDYINASYVMGYHESNQFIITQHPLLHTIKDFWRMMWDHNSQLIVMLPDNQ 2091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	22/101 (22%)
		fn3	220..304	CDD:278470	18/89 (20%)
		fn3	315..391	CDD:278470	14/75 (19%)
		FN3	405..494	CDD:238020	16/100 (16%)
		FN3	511..574	CDD:238020	14/62 (23%)
		FN3	583..671	CDD:238020	17/93 (18%)
		fn3	683..753	CDD:278470	17/78 (22%)
		fn3	787..850	CDD:278470	8/70 (11%)
		fn3	866..935	CDD:278470	23/109 (21%)
		fn3	961..1043	CDD:278470	16/86 (19%)
		PTPc	1272..1525	CDD:214550	122/273 (45%)
		PTPc	1298..1525	CDD:238006	109/238 (46%)
ptprz1	NP_001362251.1	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..395	CDD:365830
		PTP_DSP_cys	1690..1960	CDD:391942	123/277 (44%)
		R-PTP-Z-2	2043..2246	CDD:350507	8/49 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910