DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and cdc25c

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_031753389.1	Gene:	cdc25c / 100124300	XenbaseID:	XB-GENE-944821	Length:	567	Species:	Xenopus tropicalis

Alignment Length:	306	Identity:	62/306 - (20%)
Similarity:	102/306 - (33%)	Gaps:	77/306 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1662 SKGGNIDVLESQQQQQQQQQQQPNQGGHNITTISAINGYNTLQHRRKSQLITFSSSS-----CDI 1721
            |.||:.:|:........:...:.|||.|..|....|  .|.|  |.|...:|||...     .|:
Frog    10 SSGGSAEVMAENHIMSSEAPPKSNQGLHFRTNCRMI--LNLL--REKDSSVTFSPEQPLTPVTDL 70

  Fly  1722 KNSLSHEYINGSNGSAANGPPS------SGSGSGSGPGSNRASRANVRLSFAEEDVMILPQNHSQ 1780
            .       :..||.|...|...      |..|..:||           |.....|.|.|.:..|.
Frog    71 A-------VGFSNLSTFTGETPKRCLDLSNLGDETGP-----------LPTESPDRMSLGKVESP 117

  Fly  1781 QSNH-QDDEVFTRRRSLLEVEIGVEV-----GEDGELAPHEM------------EEDLEEEDEDE 1827
            ::.. |.|.:||       .::|.:.     |....:.|..:            :..:..::.:.
Frog   118 KTQFVQFDGLFT-------PDLGCKAKKCQRGNMNSVLPRLLCSTPSFKKTSGGQRSMSNKENES 175

  Fly  1828 ELYMHDEFETHIDTKSNNANDDSGGGSYEDSHALHSSLGGSNRNSLEKDDDDIEVDVISTDVSCY 1892
            ||:.:...:.........|.|.....:.||.  :..||           |:|.|::::.:.:|.
Frog   176 ELFKNPNCKPVALVLPQEAVDSQFSPAPEDK--VDISL-----------DEDCEMNILGSPISA- 226

  Fly  1893 DQLLGSSCNTRNGDDDDIATLVGDGDYSTTKLSKASRLSGAGVGGL 1938
                .:.|.....||..:..|.|..|:.:....:....||| ||.|
Frog   227 ----AAPCLEGPHDDIKMQNLDGFADFFSVDEEEIENPSGA-VGNL 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550
		PTPc	1298..1525	CDD:238006
cdc25c	XP_031753389.1	M-inducer_phosp	137..368	CDD:399542	26/150 (17%)
cdc25c	XP_031753389.1	Cdc25	399..518	CDD:238788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860