DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and ARNT2

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_055677.3	Gene:	ARNT2 / 9915	HGNCID:	16876	Length:	717	Species:	Homo sapiens

Alignment Length:	755	Identity:	162/755 - (21%)
Similarity:	274/755 - (36%)	Gaps:	190/755 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAPETGNTGSTGSAGSTGSGSGSG------SGSGSSSDPANGREARNLAEKQRRDKLNASIQEL 59
            |||  ||.....|:..:.|....||      .|.|.|.   ..||..:..|::||:|:...|.||
Human    27 MAA--TGQVRMAGAMPARGGKRRSGMDFDDEDGEGPSK---FSRENHSEIERRRRNKMTQYITEL 86

  Fly    60 ATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDLPN--PS 122
            :.|||..:..:|:.||..:||.|...::                .::|||..::.....|:  ..
Human    87 SDMVPTCSALARKPDKLTILRMAVSHMK----------------SMRGTGNKSTDGAYKPSFLTE 135

  Fly   123 LHLTDTLMQLLD-CCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLI 186
            ..|...:::..| ..|:....:|:::.||.||..:|...||:.:|..|.:..||||.:.||:||
Human   136 QELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQL- 199

  Fly   187 PRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSG-SDLEEEEMETEEHRLGRQQGEADDDEDHPY 250
                                    .||.::.|.. .||:...::.|    |:|..
Human   200 ------------------------CTSENSMTGRILDLKTGTVKKE----GQQSS---------- 226

  Fly   251 NRRTPSPRRMAHLATIDDRLRM---DRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTG 312
                               :||   .||.|..|:.                   |         |
Human   227 -------------------MRMCMGSRRSFICRMR-------------------C---------G 244

  Fly   313 GAAANY-PIVSQLIRRSRNNNMLAAAAAVAAEAATV---------PPQHDAIAQAALHGISGNDI 367
            .|..:: |:......|.|..|.|.......|:.|.|         ||....|.:.......|:..
Human   245 NAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKY 309

  Fly   368 VLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEV 432
            .|||:.|:       :.|...|.:.:.....|  .|:.:||..||.|...|.|...|.||...::
Human   310 CLVAIGRL-------QVTSSPVCMDMNGMSVP--TEFLSRHNSDGIITFVDPRCISVIGYQPQDL 365

  Fly   433 --RNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKV 495
              :::..||  |.:|...:..:.:|:...........||..::|..::.:.|..|...:..|:::
Human   366 LGKDILEFC--HPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEI 428

  Fly   496 HSFLCVNTLLDEEAGRQKVQEMKEK--FSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENL 558
            ...:|.||.:.:...:|...|:.::  .|:...:::|.    |:|||.             :...
Human   429 EYIICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPV----PNLPAG-------------VHEA 476

  Fly   559 QKSVDSAETVGGQGME---SLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVS 620
            .|||:.|:.:..|..:   :.|..|.|:....:.....|.......:...|.||. .|..:.|.|
Human   477 GKSVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSG-HSGKAFSSS 540

  Fly   621 VVNVTAARKFQQEHQKQRERDREQLKERTNSTQ-----------GVIRQLSSCLSEAETASCILS 674
            ||:|......|.  .....::..|:..:.|.:|           |  :|:.|..|:.::     |
Human   541 VVHVPGVNDIQS--SSSTGQNMSQISRQLNQSQVAWTGSRPPFPG--QQIPSQSSKTQS-----S 596

  Fly   675 PASSLSASEAPDTPDPHSNTSPP----PSLHTRPSVLHRT 710
            |....::...|..|..:|..|.|    ||.:...|:.:||
Human   597 PFGIGTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRT 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	18/48 (38%)
		PAS	137..>186	CDD:238075	18/48 (38%)
		PAS_11	403..510	CDD:291273	25/108 (23%)
ARNT2	NP_055677.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..74		10/41 (24%)
		bHLH-PAS_ARNT	62..124	CDD:381517	21/80 (26%)
		PAS	137..243	CDD:395786	35/182 (19%)
		PAS_11	336..436	CDD:405306	23/101 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..717		20/98 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740