Protein Alignment Met and CLOCK

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_004889.1
• Gene: CLOCK / 9575
• HGNCID: 2082
• Length: 846
• Species: Homo sapiens
• Alignment Length: 668
• Identity: 133/668 - (19%)
• Similarity: 236/668 - (35%)
• Gaps: 224/668 - (33%)

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            |.:||.:||:|||:.|..|:||.:|:|   .::|::||:.||:.:...||........:.....:
Human    36 RVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHKEITAQSDASEIR 97

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQ 167
            ...|.|.:|          :...|..:::.||..||.:...|.|:.||.||..||.|..|||..|
Human    98 QDWKPTFLS----------NEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQ 152

  Fly   168 NLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEE 232
            ::.             ..||               :|.:.:.:...:      :.|.|.:..|.|
Human   153 SIF-------------NFIP---------------EGEHSEVYKILS------THLLESDSLTPE 183

  Fly   233 HRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYERV 297
            :...:.|.|                                   |...:.|.:...:....||.|
Human   184 YLKSKNQLE-----------------------------------FCCHMLRGTIDPKEPSTYEYV 213

  Fly   298 KIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGI 362
            |..|.| :|.:|::..|...:....|...|                    |...|.:...|
Human   214 KFIGNF-KSLNSVSSSAHNGFEGTIQRTHR--------------------PSYEDRVCFVA---- 253

  Fly   363 SGNDIVLVAMARVLRE----ERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGL 423
                .|.:|..:.::|    |.|.|                   |:.:||.::...:..|.|...
Human   254 ----TVRLATPQFIKEMCTVEEPNE-------------------EFTSRHSLEWKFLFLDHRAPP 295

  Fly   424 VAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDY-----GESC-YRLLSRNGRFIYLHT 482
            :.||:..||...|.:.:.|:||       |..:..|:...     |:|| ||.|::..::|:|.|
Human   296 IIGYLPFEVLGTSGYDYYHVDD-------LENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQT 353

  Fly   483 KGFLEVDRGSNKVHSFLCVNTLL---DEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAP 544
            ..::...:.:::....:|.:|::   :..|.|::              |:..:.|.|:..|.::
Human   354 HYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRR--------------ELGIEESLPETAADKS- 403

  Fly   545 QQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAP----SPTPALA--- 602
                                            .|.|..:..||::|:|...    ||||:.:
Human   404 --------------------------------QDSGSDNRINTVSLKEALERFDHSPTPSASSRS 436

  Fly   603 ------LVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSS 661
                  .....|||..:.|....|    |..|:....|:|..:| |.....::.::|.|    .|
Human   437 SRKSSHTAVSDPSSTPTKIPTDTS----TPPRQHLPAHEKMVQR-RSSFSSQSINSQSV----GS 492

  Fly   662 CLSEAETASCILSPASSL 679
            .|::.     ::|.|::|
Human   493 SLTQP-----VMSQATNL 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	21/50 (42%)
		PAS	137..>186	CDD:238075	15/48 (31%)
		PAS_11	401..510	CDD:464214	26/117 (22%)
CLOCK	NP_004889.1	bHLH-PAS_CLOCK	29..89	CDD:381577	21/55 (38%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785	32..47		5/10 (50%)
		PAS	109..>175	CDD:395786	21/99 (21%)
		PAS_11	274..377	CDD:464214	27/128 (21%)
		Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:O08785	371..845		36/196 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..411		5/51 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..495		18/83 (22%)
		Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785	450..570		16/70 (23%)
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564
		SP1-4_N	550..>694	CDD:425404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..654
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..783
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	811..846