Protein Alignment Met and NCOA1

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_003734.3
• Gene: NCOA1 / 8648
• HGNCID: 7668
• Length: 1441
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 154/791 - (19%)
• Similarity: 263/791 - (33%)
• Gaps: 203/791 - (25%)

  Fly    26 SGSG-SSSDPAN-------GREARNLA---EKQRRDKLNASIQELATM----VPHAAESSRRLDK 75
            ||.| |||||||       |.....||   ||:||::.|..::|||.:    :......|.:.||
Human     2 SGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDK 66

  Fly    76 TAVLRFATHGLRLQYVFGKSASRRRKKT--GLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFL 138
            ..:|:.....::|.    |...:.:..|  .::.:.:|:|..|.:...|  |...|::.||..|.
Human    67 CKILKKTVDQIQLM----KRMEQEKSTTDDDVQKSDISSSSQGVIEKES--LGPLLLEALDGFFF 125

  Fly   139 TLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQ 203
            .:.|.|:||.||.:|...||:.|.:|...::..|.|..|.....:.|:|:.:           ..
Human   126 VVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSL-----------VN 179

  Fly   204 GHNPQQHSTSTSASTSGSDL-----EEEEMETEE----------HRLGRQQGEADDDEDHP---- 249
            |....|.:|..::.|....:     :|...|.:|          ..:.:.:...:|.||..
Human   180 GVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLI 244

  Fly   250 -YNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYE---RVKIDGCFR---RSD 307
             ..||.|.|..:..:.:.  ..:.|.....:.:..:|.||.....:|   |..|...|:   |..
Human   245 CIARRLPRPPAITGVESF--MTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREP 307

  Fly   308 S--------SLTGGAAA--NYPIVSQLIRRSRNNNMLAAAA--------------------AVAA 342
            |        .:|.|.|:  :|..:      ..:..||:|..                    .:..
Human   308 SYARQLFQEVMTRGTASSPSYRFI------LNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDR 366

  Fly   343 EAATVPPQHDAIAQAALHGISGNDIVLVAMAR-VLREERPPEETEGTVGLTIYR-QPEPYQLEYH 405
            |.:.:.||.|..:..::..::.:....::.|. |.|....|......|...|.| |........|
Human   367 EHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSH 431

  Fly   406 TRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRL 470
            :..........|.....:||.                        |||.|        |::
Human   432 SNSSNSQGSFGCSPGSQIVAN------------------------VALNQ--------GQA---- 460

  Fly   471 LSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMKEK----FSTIIKAEMPT 531
                                .|...:..|.:|....|..|....|.|..:    .....:..||.
Human   461 --------------------SSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPN 505

  Fly   532 QSSSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAPS 596
            .|..|::....:|..:....   ..|..:|..:......|||....::.....|::..|.:::..
Human   506 NSFPPNISTLSSPVGMTSSA---CNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQ 567

  Fly   597 PTPALALVPPAPSSVKSSISKSVSVVNVTAARKFQQE--------------HQKQRERDREQLKE 647
            .:|:...:.||.:..|.: .:..|::|    ...|.:              |...|..|.:....
Human   568 NSPSRLNIQPAKAESKDN-KEIASILN----EMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYS 627

  Fly   648 RTNS------TQGVIRQL------SSCLSEAETASCILSPASSLSASEAPDTPDPHSNTSPPPSL 700
            :|:.      |....:||      :||   .:..||..:..|:.:.|.....|..||      ||
Human   628 QTSHKLVQLLTTTAEQQLRHADIDTSC---KDVLSCTGTSNSASANSSGGSCPSSHS------SL 683

  Fly   701 HTRPSVLHRTL 711
            ..|..:|||.|
Human   684 TERHKILHRLL 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	14/57 (25%)
		PAS	137..>186	CDD:238075	15/48 (31%)
		PAS_11	401..510	CDD:464214	13/108 (12%)
NCOA1	NP_003734.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		17/36 (47%)
		bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	16/63 (25%)
		LXXLL motif 1	46..50		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..105		3/21 (14%)
		LXXLL motif 2	112..116		1/3 (33%)
		PAS	120..213	CDD:238075	25/103 (24%)
		PAS_11	259..370	CDD:464214	18/118 (15%)
		Interaction with STAT3. /evidence=ECO:0000269|PubMed:11773079	361..567		40/264 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..443		12/74 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..477		5/51 (10%)
		NCOA_u2	468..590	CDD:465223	22/125 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..585		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..626		4/28 (14%)
		SRC-1	629..708	CDD:462615	20/75 (27%)
		LXXLL motif 3	633..637		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..723		12/39 (31%)
		LXXLL motif 4	690..694		3/3 (100%)
		DUF4927	741..818	CDD:465083
		LXXLL motif 5	749..753
		Interaction with CREBBP	781..988
		LXXLL motif 6	913..917
		Nuc_rec_co-act	924..969	CDD:462608
		Med15	974..>1287	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1143..1188
		DUF1518	1149..1205	CDD:462174
		DUF1518	1212..1268	CDD:462174
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1409..1441
		LXXLL motif 7	1435..1439