DRSC/TRiP Functional Genomics Resources

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Protein Alignment Met and Ncoa2

DIOPT Version :10

Sequence 1:NP_511126.2 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_114010.2 Gene:Ncoa2 / 83724 RGDID:620108 Length:1465 Species:Rattus norvegicus


Alignment Length:932 Identity:172/932 - (18%)
Similarity:299/932 - (32%) Gaps:297/932 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 SGSG-SSSDPAN-------------GREARNLAEKQRRDKLNASIQELATMV----PHAAESSRR 72
            ||.| ::|||:.             |...:...||:.|::.|..|:|||.::    ......:.:
  Rat     2 SGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFK 66

  Fly    73 LDKTAVLRFATHGLRLQYVFGKSASR---RRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLD 134
            .||.|:|:.....:|......|:|:.   ..:|:.:..||.     |.:...:  |...:::.||
  Rat    67 PDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQ-----GVIDKDA--LGPMMLEALD 124

  Fly   135 CCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQH 199
            ..|..:...|.:|.||.:|.|.|.:.|.:|..:::..|.|..|.....:.|:|:.:.      ..
  Rat   125 GFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMV------NG 183

  Fly   200 HQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEA-------------DDDEDHP-- 249
            ....|..|:::|.:.:.......|.:.|.|..:::...|:.|.             ::.||..  
  Rat   184 GSWTGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSC 248

  Fly   250 ---YNRRTPSPRRMAHLATIDDRLRMD-------------------------RRCFTVRLARAST 286
               ..||.|...|.|..::.....|.|                         |||    :.:..|
  Rat   249 LICVARRVPMKERPALPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRC----IQKFHT 309

  Fly   287 RAE------ATRHYERVKIDGC-------FRRSDSSLTGGAAANYPIVSQ------------LIR 326
            :.|      |.||:..|...|.       |..||.:|......:..|.||            ::.
  Rat   310 QHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLH 374

  Fly   327 RSRNNNMLAAAAAVAAEAATVPPQHDA--IAQAALHGISGNDIVL----------------VAMA 373
            |.:|..::.......|....:.|...:  ..||...|..|.|:.|                :.|.
  Rat   375 REQNVCVMNPDLTGQAMGKPLSPMSSSSPARQAMCSGNPGQDVALGSNMNFPMNGPREQMSMPMG 439

  Fly   374 R-----------------------VLREERPPEETEG----------------TVGLTIYRQPEP 399
            |                       .|:...|.:.:.|                :.|:....:..|
  Rat   440 RFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGLNPGQPSSVLSPRHRMSPGVAGSPRVPP 504

  Fly   400 YQL----EYHT----------RHLIDGSIIDCDQRIG---------------LVAGYMKDEVRNL 435
            .|.    ..|:          .|....|.::..|.:.               |..|..::...|:
  Rat   505 SQFSPAGSLHSPAGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGPSLASPDLKMGNSQNSPVNM 569

  Fly   436 SPFCFMHLDDVRWVIVALRQMYDCNSDYGE-----------SCYRLLSR--NGRFIYLHTKGFLE 487
            :|.....:..:        ...||...|||           ||:....:  |...:.....|   
  Rat   570 NPPPLSKMGSL--------DSKDCFGLYGEPSEGTTGQAEASCHPEEQKRPNDSSMPQAASG--- 623

  Fly   488 VDR--GSNKVHSFLCVNTLLDEEAGRQK-VQEMKEKFSTIIKAEMPT------QSSSPDLPA--- 540
             ||  |.:::|          |..|:.| :|.:..|...:..:.:|:      :.|:..||.   
  Rat   624 -DRAEGHSRLH----------ESKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGS 677

  Fly   541 --SQAPQQLERIVLYLIENLQKSVDSAE-TVGGQGMESLMDDGYSSPANTLTLEELAPSP----- 597
              ..:.::..:|:..|:::....||.|: |....|.|...:...::|.:.:|:::...||     
  Rat   678 THGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELNQESSGTAPGSEVTVKQEPASPKKKEN 742

  Fly   598 --------------------TPAL----ALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQR 638
                                ||.|    :...||      |.:|.:::..|.....|:...|...
  Rat   743 ALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPA------SNTKLIAMKTVKEEVSFEPSDQPGS 801

  Fly   639 ERD--REQLKERTNSTQGVIRQLSSCLSE----AETAS----CILSPASSLSASEAPDTPDPHSN 693
            |.|  .|.|.:..||      ||.....:    |.|.|    .|::....|:|..:|.||.....
  Rat   802 ELDNLEEILDDLQNS------QLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVTPVGAQK 860

  Fly   694 TSPPPSLHT----RPSVLHRTL 711
            .:...|..|    ||..|.|.|
  Rat   861 AALRMSQSTFNNPRPGQLGRLL 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_511126.2 bHLH_PAS 38..89 CDD:381397 13/54 (24%)
PAS 137..>186 CDD:238075 13/48 (27%)
PAS_11 401..510 CDD:464214 23/152 (15%)
Ncoa2NP_114010.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 9/37 (24%)
bHLH-PAS_NCoA2_SRC2 28..91 CDD:381520 14/62 (23%)
PAS 123..213 CDD:238075 22/95 (23%)
PAS_11 268..378 CDD:464214 20/113 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..528 7/78 (9%)
NCOA_u2 463..587 CDD:465223 16/131 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 547..741 38/215 (18%)
SRC-1 636..709 CDD:462615 14/72 (19%)
LXXLL motif 1 641..645 1/3 (33%)
LXXLL motif 2 690..694 0/3 (0%)
CASP8AP2-binding. /evidence=ECO:0000250|UniProtKB:Q61026 691..743 11/51 (22%)
Interaction with BMAL1. /evidence=ECO:0000250|UniProtKB:Q61026 730..1121 36/165 (22%)
DUF4927 731..816 CDD:465083 16/90 (18%)
LXXLL motif 3 745..749 0/3 (0%)
LXXLL motif 4 878..882 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1075
Nuc_rec_co-act 1071..1115 CDD:462608
LLXXLXXXL motif 1079..1087
DUF1518 1281..1338 CDD:462174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1330
Blue background indicates that the domain is not in the aligned region.

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