DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Met and Ncoa2

DIOPT Version :9

Sequence 1:NP_001285132.1 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_114010.1 Gene:Ncoa2 / 83724 RGDID:620108 Length:1465 Species:Rattus norvegicus


Alignment Length:928 Identity:168/928 - (18%)
Similarity:299/928 - (32%) Gaps:289/928 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 SGSG-SSSDPAN-------------GREARNLAEKQRRDKLNASIQELATMV----PHAAESSRR 72
            ||.| ::|||:.             |...:...||:.|::.|..|:|||.::    ......:.:
  Rat     2 SGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFK 66

  Fly    73 LDKTAVLRFATHGLRLQYVFGKSASR---RRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLD 134
            .||.|:|:.....:|......|:|:.   ..:|:.:..||.     |.:...:  |...:::.||
  Rat    67 PDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQ-----GVIDKDA--LGPMMLEALD 124

  Fly   135 CCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQH 199
            ..|..:...|.:|.||.:|.|.|.:.|.:|..:::..|.|..|.....:.|:|:.:.      ..
  Rat   125 GFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMV------NG 183

  Fly   200 HQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEA-------------DDDEDHP-- 249
            ....|..|:::|.:.:.......|.:.|.|..:::...|:.|.             ::.||..  
  Rat   184 GSWTGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDKQSC 248

  Fly   250 ---YNRRTPSPRRMA--------------------HLATIDDRLR-----MDRRCFTVRLARAST 286
               ..||.|...|.|                    ..:|:.|.::     :.|||    :.:..|
  Rat   249 LICVARRVPMKERPALPSSESFTTRQDLQGKITFLDTSTMRDAMKPGWEDLVRRC----IQKFHT 309

  Fly   287 RAE------ATRHYERVKIDGC-------FRRSDSSLTGGAAANYPIVSQ------------LIR 326
            :.|      |.||:..|...|.       |..||.:|......:..|.||            ::.
  Rat   310 QHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISIHMLH 374

  Fly   327 RSRNNNMLAAAAAVAAEAATVPPQHDA--IAQAALHGISGNDIVL----------------VAMA 373
            |.:|..::.......|....:.|...:  ..||...|..|.|:.|                :.|.
  Rat   375 REQNVCVMNPDLTGQAMGKPLSPMSSSSPARQAMCSGNPGQDVALGSNMNFPMNGPREQMSMPMG 439

  Fly   374 R-----------------------VLREERPPEETEG----------------TVGLTIYRQPEP 399
            |                       .|:...|.:.:.|                :.|:....:..|
  Rat   440 RFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGLNPGQPSSVLSPRHRMSPGVAGSPRVPP 504

  Fly   400 YQL----EYHT----------RHLIDGSIIDCDQRIG---------------LVAGYMKDEVRNL 435
            .|.    ..|:          .|....|.::..|.:.               |..|..::...|:
  Rat   505 SQFSPAGSLHSPAGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGPSLASPDLKMGNSQNSPVNM 569

  Fly   436 SPFCFMHLDDVRWVIVALRQMYDCNSDYGE-----------SCYRLLSRNGRFIYLHTKGFLEVD 489
            :|.....:..:        ...||...|||           ||:....:......:......:..
  Rat   570 NPPPLSKMGSL--------DSKDCFGLYGEPSEGTTGQAQASCHPEEQKRPNDSSMPQAASEDRA 626

  Fly   490 RGSNKVHSFLCVNTLLDEEAGRQK-VQEMKEKFSTIIKAEMPT------QSSSPDLPA-----SQ 542
            .|.:::|          |..|:.| :|.:..|...:..:.:|:      :.|:..||.     ..
  Rat   627 EGHSRLH----------ESKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGT 681

  Fly   543 APQQLERIVLYLIENLQKSVDSAE-TVGGQGMESLMDDGYSSPANTLTLEELAPSP--------- 597
            :.::..:|:..|:::....||.|: |....|.|...:...::|.:.:|:::...||         
  Rat   682 SLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELNQESSGTAPGSEVTVKQEPASPKKKENALLR 746

  Fly   598 ----------------TPAL----ALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERD- 641
                            ||.|    :...||      |.:|.:::..|.....|:...|...|.| 
  Rat   747 YLLDKDDTKDIGLPEITPKLERLDSKTDPA------SNTKLIAMKTVKEEVSFEPSDQPGSELDN 805

  Fly   642 -REQLKERTNSTQGVIRQLSSCLSE----AETAS----CILSPASSLSASEAPDTPDPHSNTSPP 697
             .|.|.:..||      ||.....:    |.|.|    .|::....|:|..:|.||......:..
  Rat   806 LEEILDDLQNS------QLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVTPVGAQKAALR 864

  Fly   698 PSLHT----RPSVLHRTL 711
            .|..|    ||..|.|.|
  Rat   865 MSQSTFNNPRPGQLGRLL 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_001285132.1 HLH 38..87 CDD:238036 12/52 (23%)
PAS 137..>186 CDD:238075 13/48 (27%)
PAS_11 403..510 CDD:291273 18/142 (13%)
Ncoa2NP_114010.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 9/37 (24%)
HLH 35..88 CDD:197674 13/52 (25%)
PAS 119..215 CDD:279347 23/101 (23%)
PAS 123..213 CDD:238075 22/95 (23%)
PAS_11 268..378 CDD:291273 20/113 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..528 7/78 (9%)
NCOA_u2 463..587 CDD:293270 16/131 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 547..741 34/211 (16%)
SRC-1 640..709 CDD:285981 13/68 (19%)
LXXLL motif 1 641..645 1/3 (33%)
LXXLL motif 2 690..694 0/3 (0%)
CASP8AP2-binding 691..743 11/51 (22%)
Interaction with ARNTL. /evidence=ECO:0000250|UniProtKB:Q61026 730..1121 36/165 (22%)
DUF4927 731..816 CDD:292896 16/90 (18%)
LXXLL motif 3 745..749 0/3 (0%)
LXXLL motif 4 878..882 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1075
Nuc_rec_co-act 1071..1116 CDD:285967
LLXXLXXXL motif 1079..1087
DUF1518 1281..1338 CDD:284808
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1330
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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