DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Met and NCOA3

DIOPT Version :9

Sequence 1:NP_001285132.1 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_858045.1 Gene:NCOA3 / 8202 HGNCID:7670 Length:1424 Species:Homo sapiens


Alignment Length:734 Identity:147/734 - (20%)
Similarity:236/734 - (32%) Gaps:234/734 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 SGSGSSSDP-ANGREARNL------------AEKQRRDKLNASIQELATMVPHAAESSR------ 71
            ||.|.:.|| |:....|.|            .||:||::.:..|:|||.::  :|..|.      
Human     2 SGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELI--SANLSDIDNFNV 64

  Fly    72 RLDKTAVLRFATHGLRLQYVFGKSASRRR--KKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLD 134
            :.||.|:|:.....:|.....||:.|...  :|..:..||.     |.:...|  |...|:|.||
Human    65 KPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQ-----GVIDKDS--LGPLLLQALD 122

  Fly   135 CCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDD-QDLLRQQLIPRDIETLFYQHQ 198
            .....:...|.||.||.:|.|.|.:.|.||...::..|.|.:| :|.|:.  :|:          
Human   123 GFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKN--LPK---------- 175

  Fly   199 HHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRR----TPSPRR 259
                        ||....|.:.        ||:..:            .|.:|.|    ||..  
Human   176 ------------STVNGVSWTN--------ETQRQK------------SHTFNCRMLMKTPHD-- 206

  Fly   260 MAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQL 324
                 .::|               .:...|..:.||.::   ||                     
Human   207 -----ILED---------------INASPEMRQRYETMQ---CF--------------------- 227

  Fly   325 IRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGISGNDI---VLVAMARVLREERPPEETE 386
                                        |::|.......|.|:   ::....|:...||      
Human   228 ----------------------------ALSQPRAMMEEGEDLQSCMICVARRITTGER------ 258

  Fly   387 GTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQ---RIGLVAGYMKDEVRNLSPFCFMHLDDVRW 448
                 |....||    .:.|||.:.|.:::.|.   |..:..|: :|.:|......|...|...|
Human   259 -----TFPSNPE----SFITRHDLSGKVVNIDTNSLRSSMRPGF-EDIIRRCIQRFFSLNDGQSW 313

  Fly   449 VIVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAG--- 510
            ......|....|.......||....:|..:...||..|..:..:|..|.|:..:.|..|:.|   
Human   314 SQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRP 378

  Fly   511 -----RQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENLQ--KSVDSAETV 568
                 .|.::......::.:.....:.:....:|:|:|....:......:...:  .|.:.|...
Human   379 NPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLT 443

  Fly   569 GGQGME---SLMDDGY----SSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVSVVNVTA 626
            .|.||:   |..::.|    |||          |..:|.|     ||:.....||          
Human   444 PGPGMQSPSSYQNNNYGLNMSSP----------PHGSPGL-----APNQQNIMIS---------- 483

  Fly   627 ARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASCILSPASSLSA----SEAPDT 687
                        .|:|...|..::....|....|...|...|.:...| :|||||    ||...|
Human   484 ------------PRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFS-SSSLSALQAISEGVGT 535

  Fly   688 PDPHSNTSPPPSLHTRPSV 706
            ....:.:||.|.|...|::
Human   536 SLLSTLSSPGPKLDNSPNM 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_001285132.1 HLH 38..87 CDD:238036 16/66 (24%)
PAS 137..>186 CDD:238075 16/49 (33%)
PAS_11 403..510 CDD:291273 25/109 (23%)
NCOA3NP_858045.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 10/35 (29%)
HLH 34..88 CDD:197674 16/55 (29%)
PAS 116..173 CDD:214512 20/58 (34%)
PAS 117..215 CDD:279347 32/163 (20%)
PAS_11 265..375 CDD:291273 26/114 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..493 23/121 (19%)
NCOA_u2 459..572 CDD:293270 32/134 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..520 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..674 5/18 (28%)
SRC-1 620..704 CDD:285981
LXXLL motif 1 685..689
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..730
DUF4927 723..810 CDD:292896
LXXLL motif 2 738..742
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 755..798
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..945
Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9346901 1023..1093
Nuc_rec_co-act 1045..1092 CDD:285967
LXXLL motif 3 1057..1061
Acetyltransferase 1097..1304
polyglutamine repeats 1248..1276
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1273..1321
DUF1518 1291..1348 CDD:284808
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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