DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Met and NCOA3

DIOPT Version :10

Sequence 1:NP_511126.2 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_858045.1 Gene:NCOA3 / 8202 HGNCID:7670 Length:1424 Species:Homo sapiens


Alignment Length:734 Identity:147/734 - (20%)
Similarity:236/734 - (32%) Gaps:234/734 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 SGSGSSSDP-ANGREARNL------------AEKQRRDKLNASIQELATMVPHAAESSR------ 71
            ||.|.:.|| |:....|.|            .||:||::.:..|:|||.::  :|..|.      
Human     2 SGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELI--SANLSDIDNFNV 64

  Fly    72 RLDKTAVLRFATHGLRLQYVFGKSASRRR--KKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLD 134
            :.||.|:|:.....:|.....||:.|...  :|..:..||.     |.:...|  |...|:|.||
Human    65 KPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQ-----GVIDKDS--LGPLLLQALD 122

  Fly   135 CCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDD-QDLLRQQLIPRDIETLFYQHQ 198
            .....:...|.||.||.:|.|.|.:.|.||...::..|.|.:| :|.|:.  :|:          
Human   123 GFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKN--LPK---------- 175

  Fly   199 HHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRR----TPSPRR 259
                        ||....|.:.        ||:..:            .|.:|.|    ||..  
Human   176 ------------STVNGVSWTN--------ETQRQK------------SHTFNCRMLMKTPHD-- 206

  Fly   260 MAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQL 324
                 .::|               .:...|..:.||.::   ||                     
Human   207 -----ILED---------------INASPEMRQRYETMQ---CF--------------------- 227

  Fly   325 IRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGISGNDI---VLVAMARVLREERPPEETE 386
                                        |::|.......|.|:   ::....|:...||      
Human   228 ----------------------------ALSQPRAMMEEGEDLQSCMICVARRITTGER------ 258

  Fly   387 GTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQ---RIGLVAGYMKDEVRNLSPFCFMHLDDVRW 448
                 |....||    .:.|||.:.|.:::.|.   |..:..|: :|.:|......|...|...|
Human   259 -----TFPSNPE----SFITRHDLSGKVVNIDTNSLRSSMRPGF-EDIIRRCIQRFFSLNDGQSW 313

  Fly   449 VIVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAG--- 510
            ......|....|.......||....:|..:...||..|..:..:|..|.|:..:.|..|:.|   
Human   314 SQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRP 378

  Fly   511 -----RQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENLQ--KSVDSAETV 568
                 .|.::......::.:.....:.:....:|:|:|....:......:...:  .|.:.|...
Human   379 NPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLT 443

  Fly   569 GGQGME---SLMDDGY----SSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVSVVNVTA 626
            .|.||:   |..::.|    |||          |..:|.|     ||:.....||          
Human   444 PGPGMQSPSSYQNNNYGLNMSSP----------PHGSPGL-----APNQQNIMIS---------- 483

  Fly   627 ARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASCILSPASSLSA----SEAPDT 687
                        .|:|...|..::....|....|...|...|.:...| :|||||    ||...|
Human   484 ------------PRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFS-SSSLSALQAISEGVGT 535

  Fly   688 PDPHSNTSPPPSLHTRPSV 706
            ....:.:||.|.|...|::
Human   536 SLLSTLSSPGPKLDNSPNM 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_511126.2 bHLH_PAS 38..89 CDD:381397 17/68 (25%)
PAS 137..>186 CDD:238075 16/49 (33%)
PAS_11 401..510 CDD:464214 25/111 (23%)
NCOA3NP_858045.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 10/35 (29%)
bHLH-PAS_NCoA3_SRC3 29..101 CDD:381519 19/73 (26%)
PAS 116..173 CDD:214512 20/58 (34%)
PAS_11 265..375 CDD:464214 26/114 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..493 23/121 (19%)
NCOA_u2 459..572 CDD:465223 32/134 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..520 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..674 5/18 (28%)
SRC-1 616..704 CDD:462615
LXXLL motif 1 685..689
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..730
DUF4927 723..810 CDD:465083
LXXLL motif 2 738..742
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 755..798
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 912..945
Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9346901 1023..1093
Nuc_rec_co-act 1045..1091 CDD:462608
LXXLL motif 3 1057..1061
Acetyltransferase 1097..1304
polyglutamine repeats 1248..1276
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1273..1321
DUF1518 1291..1348 CDD:462174
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.