DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and ncoa2

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_571852.1	Gene:	ncoa2 / 81884	ZFINID:	ZDB-GENE-010406-3	Length:	1505	Species:	Danio rerio

Alignment Length:	725	Identity:	132/725 - (18%)
Similarity:	225/725 - (31%)	Gaps:	271/725 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SSSDPAN--------------GREARNLAEKQRRDKLNASIQELATMV----PHAAESSRRLDKT 76
            :|||||.              |...:...||:.|:..:..|:|||.::    ......:.:.||.
Zfish     7 NSSDPARSEAQKRKEGPSDLLGPSPKRSTEKRNREHESKYIEELAELIFANFNDIDNFNVKPDKC 71

  Fly    77 AVLRFATHGLRLQYVFGKSASRRR---KKTGLKGTGMSA---SPVGDLPNPSLHLTDTLMQLLDC 135
            |:|:.....:|......|:|:...   :|..:..||.|.   ..:|.:          :::.||.
Zfish    72 AILKETVKQIRQIKEQEKAAAANEDEVQKADVSSTGQSVIDKDALGPM----------MLEALDG 126

  Fly   136 CFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHH 200
            .|..:...|.||.||.:|.|.|.:.|.:|...::..|.|..|.....:.|:|:.          |
Zfish   127 FFFVVNMEGNIVFVSENVTQYLRYNQEELMNTSVYSILHVGDHAEFIKNLLPKS----------H 181

  Fly   201 QQ----QGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMA 261
            ..    ...||:::|.:.:.          .|....|      .||::.:||
Zfish   182 VNGVPWSSENPRRNSHTFNC----------RMLVNPH------SEAEETQDH------------- 217

  Fly   262 HLATIDDRLRMDRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIR 326
                                       ||.:.||.::   ||
Zfish   218 ---------------------------EAQQKYETMQ---CF----------------------- 229

  Fly   327 RSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGISGNDI--VLVAMA-RVLREERPPEETEGT 388
                         ..:|..::..:             |.|.  .|:.:| ||..:|||
Zfish   230 -------------AVSEPKSIKEE-------------GEDFQSCLICVARRVPMKERP------- 261

  Fly   389 VGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCF--MHLDDVRWVIV 451
                    ..|.|..:.||..:.|.|...|  ..|:...||....:|...|.  .||.:...:..
Zfish   262 --------MLPTQESFTTRQDLQGKITSLD--TSLLRASMKPGWEDLVRRCIQRFHLQNDGDISF 316

  Fly   452 ALRQMYDCNSDYGES---CYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQK 513
            |.|...:. ..:|::   .||....:|..:..|||..|.....:|:...::.::
Zfish   317 AKRHQQEV-IRHGQAFSPIYRFSLSDGTIVSAHTKSKLVRSSSTNEPQLYMSLH----------- 369

  Fly   514 VQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGG----QGME 574
                      |::.|.|....:.||..:|.           :......:.|..|.|.    ||.:
Zfish   370 ----------ILQREQPVCGMASDLGNAQT-----------MGKPMNPMSSPNTAGSSCTPQGQD 413

  Fly   575 SLMDDGYSSPANTLTLEELAPSPTPALALVPPA------PSSVKSSISKSVSVVNVTAARKFQQE 633
            :.:.      :||.|.      |:|.....|.|      |.::..|.:
Zfish   414 ATIS------SNTSTF------PSPGAQKEPGAMHRFGCPGTMSHSAT----------------- 449

  Fly   634 HQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASCILSP--ASSLSASEAPDTPDPHSNTSP 696
                       ::..|....|...:||   |.::.:..:|||  .:|...:.:|..|.|  ..||
Zfish   450 -----------MQAATPQGSGYPLKLS---SPSQGSPGMLSPRHRASPGVAGSPRLPPP--QFSP 498

  Fly   697 PPSLHTRPSV 706
            ..|||:..|:
Zfish   499 AGSLHSPASM 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	11/52 (21%)
		PAS	137..>186	CDD:238075	14/48 (29%)
		PAS_11	403..510	CDD:291273	23/111 (21%)
ncoa2	NP_571852.1	basic helix-loop-helix DNA-binding domain	18..86		13/67 (19%)
		HLH	36..89	CDD:197674	12/52 (23%)
		PAS	119..176	CDD:214512	16/66 (24%)
		PAS A domain	125..184		18/68 (26%)
		PAS_11	267..375	CDD:291273	24/131 (18%)
		PAS B domain	269..330		15/63 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..515		32/162 (20%)
		NCOA_u2	460..567	CDD:293270	16/54 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..562
		SRC-1	629..705	CDD:285981
		NR Box	630..634
		NR Box	686..690
		DUF4927	728..803	CDD:292896
		NR Box	742..746
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..962
		Nuc_rec_co-act	1061..1106	CDD:285967
		LLXXLXXXL motif. /evidence=ECO:0000255	1069..1077
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1246..1265
		HAT-like domain	1310..1378
		DUF1518	1354..1410	CDD:284808
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1475..1505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900